Oxidative Stress-Induced Endothelial Dysfunction in Cardiovascular Diseases

Frontiers in Bioscience-Landmark, Journal Year: 2022, Volume and Issue: 27(3)

Published: March 18, 2022

Cardiovascular disease (CVD) is a major cause of mortality worldwide. A better understanding the mechanisms underlying CVD key for management or prevention. Oxidative stress has been strongly implicated in pathogenesis CVD. Indeed, several studies demonstrated that reactive oxygen species (ROS), via different mechanisms, can lead to endothelial cell (EC) dysfunction, player etiology CVDs. ROS appears modulate plethora EC biological processes are critical integrity function. This review seeks dissect role oxidative stress-induced dysfunction development, with emphasis on and pathways. Special attention given ROS-induced reduction NO bioavailability, inflammation, mitochondrial dysfunction. appraisal these pathways may be essential attenuate reverse hence, reduce burden.

Language: Английский

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Verification of ferroptosis and pyroptosis and identification of PTGS2 as the hub gene in human coronary artery atherosclerosis

Free Radical Biology and Medicine, Journal Year: 2021, Volume and Issue: 171, P. 55 - 68

Published: May 8, 2021

Language: Английский

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The SARS‐CoV‐2 main protease (M^pro): Structure, function, and emerging therapies for COVID‐19

MedComm, Journal Year: 2022, Volume and Issue: 3(3)

Published: July 14, 2022

The main proteases (M

Language: Английский

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Efficient Data-Driven Machine Learning Models for Cardiovascular Diseases Risk Prediction

Sensors, Journal Year: 2023, Volume and Issue: 23(3), P. 1161 - 1161

Published: Jan. 19, 2023

Cardiovascular diseases (CVDs) are now the leading cause of death, as quality life and human habits have changed significantly. CVDs accompanied by various complications, including all pathological changes involving heart and/or blood vessels. The list includes hypertension, coronary disease, failure, angina, myocardial infarction stroke. Hence, prevention early diagnosis could limit onset or progression disease. Nowadays, machine learning (ML) techniques gained a significant role in disease prediction an essential tool medicine. In this study, supervised ML-based methodology is presented through which we aim to design efficient models for CVD manifestation, highlighting SMOTE technique's superiority. Detailed analysis understanding risk factors shown explore their importance contribution prediction. These fed input features plethora ML models, trained tested identify most appropriate our objective under binary classification problem with uniform class probability distribution. Various were evaluated after use non-use Synthetic Minority Oversampling Technique (SMOTE), comparing them terms Accuracy, Recall, Precision Area Under Curve (AUC). experiment results showed that Stacking ensemble model 10-fold cross-validation prevailed over other ones achieving Accuracy 87.8%, Recall 88.3%, 88% AUC equal 98.2%.

Language: Английский

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Ganoderma lucidum: a comprehensive review of phytochemistry, efficacy, safety and clinical study

Deleted Journal, Journal Year: 2023, Volume and Issue: 13(2), P. 568 - 596

Published: April 14, 2023

Ganoderma lucidum (G. lucidum), one of the most well-known edible fungi, is believed to be very beneficial for longevity and vitality. A long usage history suggests that G. has various clinical therapeutic effects. And experimental studies have confirmed multiple pharmacological effects, including antitumor, anti-microbial, anti-HIV protease, antidiabetic activity so on. With deepening research, more than 300 compounds been isolated from lucidum. There an increasing population G. lucidum-based products, its international development expanding. Currently, drawn much attention chemical composition, effect, value, safety. This paper provides a comprehensive review these aspects enhance global promotion

Language: Английский

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Anti-inflammatory activity of phytochemicals from medicinal plants and their nanoparticles: A review

Current Research in Biotechnology, Journal Year: 2023, Volume and Issue: 6, P. 100152 - 100152

Published: Jan. 1, 2023

Plant-based phytochemicals are known for their potential sources of anti-inflammatory agents. Various studies reported the disease-healing efficiency medicinal plants' crude extracts, pure compounds, and metal/metal oxide nanoparticles (M/MONPs) against inflammation. The purpose this paper is to review current research status plants as agents by various studies. Phytochemicals representing class flavonoids, terpenoids, polyphenols, saponins, tannins, alkaloids, anthraquinones, chemical constituents essential oils, some M/MONPs were from about 50 treatment inflammatory diseases. natural products these demonstrated promising activities treat skin, liver, cardiovascular, joint, gastrointestinal, neurological, lung inflammation Besides, mechanism actions also summarized briefly. phytochemistry, M/MONPs, have developed novel, safe, lesser side effects Hence, may draw attention scholars more toward investigation in different health disorders.

Language: Английский

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Terpenoids in essential oils: Chemistry, classification, and potential impact on human health and industry

Phytomedicine Plus, Journal Year: 2024, Volume and Issue: 4(2), P. 100549 - 100549

Published: March 24, 2024

Terpenoids, present in essential oils (EOs), have gained significant attention due to their diverse pharmacological properties and alignment with the growing global interest natural sustainable products. EOs, derived from various plants, shown promise antimicrobial, anti-inflammatory, antioxidant, other valuable applications. This comprehensive review aims elucidate chemistry roles of terpenoids covering classification, extraction techniques, potential pharmaceutical We delve into functions human immune system, impact on health, contributions environmental sustainability. The synthesizes existing literature, categorizing distinct classes, including monoterpenoids, sesquiterpenoids, diterpenoids, sesterterpenoids, triterpenoids. explore purification methods, such as steam distillation, solvent extraction, chromatography. Additionally, we discuss terpenoids, anticancer activities. Terpenoids EOs exhibit potent antimicrobial antioxidant activities, making them pivotal plant disease resistance. They also offer therapeutic applications phytomedicine, aromatherapy, beyond, capacity enhance system combat viruses, inflammation, cancer. demonstrated multifaceted benefits, contributing well-being highlights medical treatments everyday life, emphasizing need understand pharmacokinetics efficacy for harnessing full beyond.

Language: Английский

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Exploring herbal medicine regulation in Nigeria: Balancing traditional practices with modern standards

GSC Advanced Research and Reviews, Journal Year: 2024, Volume and Issue: 18(3), P. 083 - 090

Published: March 9, 2024

The regulation of herbal medicine in Nigeria stands at the intersection tradition and modernity, presenting a complex landscape shaped by historical practices, cultural beliefs, contemporary healthcare standards. This paper delves into intricate dynamics surrounding Nigeria, aiming to elucidate challenges opportunities inherent balancing traditional practices with modern regulatory Drawing from multidisciplinary approach encompassing medical anthropology, public health, legal studies, this research explores roots tracing its evolution indigenous healing current status within broader system. It examines significance medicine, considering role local communities enduring relevance addressing needs, particularly underserved rural areas. However, alongside rich tapestry healing, concerns regarding safety, efficacy, standardization have prompted calls for reforms align scrutinizes existing frameworks governing analyzing strengths, weaknesses, gaps therein. tension between preserving knowledge ensuring consumer protection, highlighting need nuanced that respects heritage while safeguarding health. Furthermore, assesses implications interventions on various stakeholders, including practitioners, consumers, policymakers. considers strategies enhancing collaboration healers formal sector, fostering mutual respect, promoting evidence-based practices. Ultimately, study underscores imperative striking delicate balance modernity regulating advocating harmonized upholds both integrity quality.

Language: Английский

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Exploration of natural products for the development of promising Cholinesterase inhibitors in Alzheimer’s disease treatment

Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42479 - e42479

Published: Feb. 1, 2025

Cholinesterase enzymes (BuChE and AChE) are privileged biological targets for the symptomatic treatment of Alzheimer's disease. Indeed, inhibition cholinesterase has been proven to improve neurotransmission mechanisms in disease patients. In this investigation, we attempt highlight new inhibitors from natural products. For purpose, secondary metabolites (299 phytoconstituents) twenty-eight Medicinal plants were virtually screened using molecular docking, pharmacokinetic toxicological analysis. Ten phytoconstituents (L82, L86, L92, L121, L148, L187, L211, L221, L228) exhibited their high binding affinity with BuChE, five phytoconstituents, namely L119, L147, L149, L192 L193, strong ability AChE. Subsequently, these evaluated ADMET properties. As result, L221 is predicted be highly bioavailable readily absorbed by human intestinal tract without significant toxicity concerns, making it suitable oral administration. Crucially, can penetrate blood-brain barrier (BBB), allowing effectively reach central nervous system. Molecular dynamics simulations MM-PBSA analysis revealed that best-screened phytoconstituent form thermodynamically favorable stable complex BuChE site. The conducted investigations highlighted promising outcomes orient towards rational development effective inhibitors.

Language: Английский

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Chinmedomics, a new strategy for evaluating the therapeutic efficacy of herbal medicines

Pharmacology & Therapeutics, Journal Year: 2020, Volume and Issue: 216, P. 107680 - 107680

Published: Sept. 18, 2020

Language: Английский

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