Clinical Science,
Journal Year:
2020,
Volume and Issue:
134(12), P. 1403 - 1432
Published: June 1, 2020
Flavonoids
are
polyphenolic
compounds
naturally
occurring
in
fruits
and
vegetables,
addition
to
beverages
such
as
tea
coffee.
emerging
potent
therapeutic
agents
for
cardiovascular
well
metabolic
diseases.
Several
studies
corroborated
an
inverse
relationship
between
flavonoid
consumption
disease
(CVD)
or
adipose
tissue
inflammation
(ATI).
exert
their
anti-atherogenic
effects
by
increasing
nitric
oxide
(NO),
reducing
reactive
oxygen
species
(ROS),
decreasing
pro-inflammatory
cytokines.
In
addition,
flavonoids
alleviate
ATI
triglyceride
cholesterol
levels,
attenuating
inflammatory
mediators.
Furthermore,
inhibit
synthesis
of
fatty
acids
promote
oxidation.
this
review,
we
discuss
the
effect
main
classes
flavonoids,
namely
flavones,
flavonols,
flavanols,
flavanones,
anthocyanins,
isoflavones,
on
atherosclerosis
ATI.
dissect
underlying
molecular
cellular
mechanisms
action
these
flavonoids.
We
conclude
supporting
potential
benefit
management
treatment
CVD;
yet,
call
more
robust
clinical
safety
pharmacokinetic
values.
Evidence-based Complementary and Alternative Medicine,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 21
Published: July 4, 2022
Cardiovascular
diseases
(CVDs)
are
the
world's
leading
killers,
accounting
for
30%
deaths.
According
to
WHO
report,
CVDs
kill
17.9
million
people
per
year,
and
there
will
be
22.2
deaths
from
CVD
in
2030.
The
death
rates
rise
as
get
older.
Regarding
gender,
rate
of
women
by
(51%)
is
higher
than
that
men
(42%).
To
decrease
prevent
CVD,
most
rely
on
traditional
medicine
originating
plant
(phytochemicals)
addition
or
preference
commercially
available
drugs
recover
their
illness.
therapy
efficacy
92
plants,
including
15
terrestrial
examined.
Some
medicinal
plants
well
known
treat
are,
Oxidative Medicine and Cellular Longevity,
Journal Year:
2021,
Volume and Issue:
2021(1)
Published: Jan. 1, 2021
Due
to
its
vast
therapeutic
potential,
the
plant‐derived
polyphenol
curcumin
is
utilized
in
an
ever‐growing
number
of
health‐related
applications.
Here,
we
report
extraction
methodologies,
properties,
advantages
and
disadvantages
linked
employment,
new
strategies
addressed
improve
effectiveness
by
employing
advanced
nanocarriers.
The
emerging
nanotechnology
applications
used
enhance
CUR
bioavailability
targeted
delivery
specific
pathological
conditions
are
collected
discussed.
In
particular,
aspects
concerning
main
strategic
nanocarriers
employed
for
treating
inflammation
oxidative
stress‐related
diseases
reported
discussed,
with
emphasis
on
those
topically
such
as
wounds,
arthritis,
or
psoriasis
others
pathologies
bowel
(colitis),
neurodegenerative
(Alzheimer’s
dementia),
cardiovascular
(atherosclerosis),
lung
(asthma
chronic
obstructive
pulmonary
disease)
diseases.
A
brief
overview
relevant
clinical
trials
also
included.
We
believe
review
can
provide
readers
nanostrategies
currently
highlighted
conditions.
Current Pharmaceutical Design,
Journal Year:
2022,
Volume and Issue:
28(45), P. 3618 - 3636
Published: Dec. 1, 2022
Abstract:
Insomnia
is
well-known
as
trouble
in
sleeping
and
enormously
influences
human
life
due
to
the
shortage
of
sleep.
Reactive
Oxygen
Species
(ROS)
accrue
neurons
during
waking
state,
sleep
has
a
defensive
role
against
oxidative
damage
dissipates
ROS
brain.
In
contrast,
insomnia
source
inequity
between
generation
removal
by
an
endogenous
antioxidant
defense
system.
The
relationship
insomnia,
depression,
anxiety
disorders
damages
cardiovascular
systems'
immune
mechanisms
functions.
Traditionally,
polysomnography
used
diagnosis
insomnia.
This
technique
complex,
with
long
time
overhead.
this
work,
we
have
proposed
novel
machine
learning-based
automatic
detection
system
using
R-R
intervals
extracted
from
single-lead
electrocardiograph
(ECG).
Additionally,
aimed
explore
stress
inflammation
diseases,
antioxidants’
effects,
psychopharmacological
effect
herbal
medicine.
work
been
carried
out
steps,
which
include
collecting
ECG
signal
for
normal
subjects,
analyzing
signal,
finally,
classification.
We
two
approaches,
including
subjects
(normal
insomnia),
stages,
i.e.,
wake
rapid
eye
movement,
three
Machine
Learning
(ML)-based
classifiers
complete
A
total
number
3000
segments
were
collected
18
subjects.
Furthermore,
theranostics
approach,
mitochondrial
dysfunction
causing
inflammatory
response
diseases
was
explored.
data
various
databases
on
mechanism
action
different
medicines
antidepressant
activities
also
retrieved.
Random
Forest
(RF)
classifier
shown
highest
accuracy
(subjects:
87.10%
stage:
88.30%)
compared
Decision
Tree
(DT)
Support
Vector
(SVM).
results
revealed
that
suggested
method
could
perform
well
classifying
stages.
random
forest
be
helpful
clinical
discovery
complications,
evidence
retrieved
showed
medicine
contains
numerous
phytochemical
bioactives
multimodal
cellular
action,
viz.,
antioxidant,
anti-inflammatory,
vasorelaxant,
detoxifier,
antidepressant,
anxiolytic,
cell-rejuvenator
properties.
Other
GABA-A
receptor
agonist
effect.
Hence,
recommend
approach
potential
can
adopted
future
research
improve
quality
humans.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
12
Published: Jan. 24, 2022
Cardiac
damage
and
vascular
dysfunction
due
to
underlying
diseases,
such
as
hypertension
cardiac
thrombosis,
or
side
effects
from
certain
drugs
may
lead
critical
illness
conditions
even
death.
The
phytochemical
compounds
in
natural
products
are
being
prospected
protect
the
heart
system
further
damage.
Moringa
genus
is
a
subtropical
tree
native
Asia
Africa,
which
includes
13
species;
oleifera
Lam.
(MO)
most
cultivated
for
its
beneficial
uses.
MO
also
known
“miracle
tree”
because
it
has
been
used
traditionally
food
source
medicine
treat
various
diseases
anemia,
diabetes,
infectious
cardiovascular
diseases.
identified
with
functional
activities
associated
N,α-L-rhamnopyranosyl
vincosamide,
isoquercetin,
quercetin,
quercetrin,
isothiocyanate.
This
study
aims
investigate
potency
of
protective
agent
disease
model.
scoping
review
by
studying
publications
reputed
database
that
assessed
MO,
contribute
improvement
dysfunctions.
Studies
show
compounds,
example,
vincosamide
have
molecular
function
antioxidant,
anti-inflammation,
anti-apoptosis.
These
improving
contractility
protecting
structural
integrity
act
vasorelaxants
endothelium
agents.
Most
studies
were
conducted
on
vivo
studies;
therefore,
should
be
applied
clinical
setting.
BioMed Research International,
Journal Year:
2023,
Volume and Issue:
2023(1)
Published: Jan. 1, 2023
Background.
Nowadays,
the
immunomodulatory
properties
of
plants
have
been
studied
extensively
with
greater
interest
due
to
increasing
awareness
and
combating
severity
diseases.
Scope
Approach.
This
paper
highlights
efficacy
available
literature
evidence
on
natural
immunomodulators
plant
origin
synthetic
ones.
In
addition,
several
aspects
their
phytoconstituents
responsible
for
immunomodulation
discussed.
Moreover,
this
review
also
discusses
mechanism
involved
in
immunomodulation.
Key
Findings.
One
hundred
fifty
medicinal
are
currently
identified
find
novel
drugs.
Of
these
plants,
family
Asteraceae
takes
first
rank
by
offering
18
species
(12%).
Similarly
so
far,
40%
belong
family.
Echinacea
purpurea
is
most
known
its
immunostimulating
activity.
The
prominent
immune-active
bioactive
molecules
polyphenols,
terpenoids,
alkaloids.
Also,
eight
were
checked
clinical
trials
found
market.
These
six
immunosuppressants,
resveratrol,
epigallocatechin-3-gallate,
quercetin,
colchicine,
capsaicin,
andrographolide,
two
immunostimulants,
curcumin
genistein.
there
a
lot
polyherbal
traditional
products
sold
market
claimed
immunomodulators.
However,
much
work
still
needed
more
active
agents.
which
exert
effect
through
induction
cytokines
phagocyte
cells
inhibition
iNOS,
PGE,
COX-2
synthesis.
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(9), P. 2534 - 2534
Published: April 25, 2024
The
endothelium
is
a
continuous
layer
of
cells
that
coats
the
interior
walls
arteries,
capillaries,
and
veins.
It
has
an
essential
regulatory
role
in
hemostatic
function,
vascular
tone,
inflammation,
platelet
activity.
Endothelial
dysfunction
characterized
by
shift
to
proinflammatory
prothrombic
state,
it
could
have
bidirectional
relationship
with
heart
failure
(HF).
Due
neurohormonal
activation
shear
stress,
HFrEF
may
promote
endothelial
dysfunction,
increase
ROS
synthesis,
reduce
nitric
oxide
production.
Different
studies
also
shown
function
damaged
HFpEF
because
systemic
inflammatory
state.
Some
clinical
trials
suggest
drugs
effect
on
patients
HF
or
cardiovascular
disease
be
therapeutic
option.
aim
this
review
highlight
pathogenetic
correlation
between
related
potential
options.
