A retrospective study of Reyanning mixture in elderly patients infected with SARS-CoV-2 Omicron variant DOI Creative Commons
Changya Liu, Xinxin Wu,

Hongqiang Yang

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: July 20, 2023

Objective: Reyanning mixture has been demonstrated to be effective in treating infected patients during the outbreak pandemic of SARS-CoV-2 Omicron variant Coronavirus disease 2019 (COVID-19) Shanghai 2022. The aim this study is further investigate role specifically treatment elderly patients. Methods: This enrolled 1,102 who were with variant. Of these, 291 received conjunction conventional Western medicine assigned group, while 811 only control group. Clinical parameters including hospitalization duration, viral shedding time, and Cycle Threshold (Ct) values novel coronavirus nucleic acid tests, as well adverse events recorded analyzed both groups. Results: There was no significant difference baseline characteristics between two In comparison group a substantial duration (median: 8 days vs. 10 days, HR: 0.638, 95% CI: 0.558-0.731, p < 0.001). also showed significantly shorter time compared 7 0.754, 0.659-0.863, Multivariate Cox proportional-hazards model analysis indicated that use closely associated reduction (HR: 1.562, 1.364-1.789, 0.001) 1.335, 1.166-1.528, addition, process, serious event occurred either Conclusion: improvement clinical indicate promising therapeutic benefit for present study. Further investigations are required validate finding by examining underlying mechanism function mixture.

Language: Английский

Comparing the effects of three decoctions for coronavirus disease 2019 on severe acute respiratory syndrome coronavirus 2-related toll-like receptors-mediated inflammations. DOI

L I Ximeng,

Kang Yuan,

L I Wenjing

et al.

PubMed, Journal Year: 2023, Volume and Issue: 43(1), P. 51 - 59

Published: Feb. 1, 2023

Language: Английский

Citations

6
Xuanfei Baidu decoction in the treatment of coronavirus disease 2019 (COVID-19): Efficacy and potential mechanisms DOI Creative Commons

Tiantian Meng,

Jingyi Ding,

Shu-Jie Shen

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(9), P. e19163 - e19163

Published: Aug. 19, 2023

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide and become a major global public health concern. Although novel investigational COVID-19 antiviral candidates such as the Pfizer agent PAXLOVID™, molnupiravir, baricitinib, remdesivir, favipiravir are currently used to treat patients with COVID-19, there is still critical need for development of additional treatments, recommended therapeutic options frequently ineffective against SARS-CoV-2. The efficacy safety vaccines remain uncertain, particularly emergence several variants. All 10 versions National Health Commission's diagnosis treatment guidelines recommend using traditional Chinese medicine. Xuanfei Baidu Decoction (XFBD) one "three medicines three prescriptions" COVID-19. This review summarizes clinical evidence potential mechanisms action XFBD treatment. With XFBD, experience improved symptoms, shorter hospital stay, prevention progression their symptoms from mild moderate reduced mortality in critically ill patients. may be associated its direct antiviral, anti-inflammatory, immunomodulatory, antioxidative, antimicrobial properties. High-quality experimental studies needed further explore underlying

Language: Английский

Citations

5
“Three medicines and three formulas” in COVID-19: from bench to bedside DOI Creative Commons
Guangxu Xiao, Simeng Wang,

Ruijiao Wang

et al.

Acupuncture and Herbal Medicine, Journal Year: 2023, Volume and Issue: 3(4), P. 309 - 322

Published: Oct. 13, 2023

Chinese guideline has proven effective in the fight against coronavirus disease 2019 (COVID-19) during global spread of epidemic. Traditional medicine (TCM) is widely recognized for its effectiveness alleviating symptoms, inhibiting progress, reducing mortality, and improving cure rate patients with COVID-19. During pandemic, “three medicines three formulas” (TMTFs) stood out from hundreds others registered clinical studies, which became highly recommended as TCM COVID-19 treatment. The TMTFs not only effectively relieve symptoms fever, cough, fatigue, phlegm, but also substantially shorten time nucleic acid negative conversion, improve lung computed tomography imaging features inflammation, ameliorate biochemical indicators, reduce sequelae. Their potential pharmacological mechanisms are mainly related to crosstalk between viral toxicity, endothelial damage, cytokine storm, immune response, microthrombus. In brief, effects on were systematically analyzed summarized covering entirety development, including virus invasion replication, response acute respiratory distress syndrome multiple organ dysfunction syndrome. This review provides a theoretical basis reference in-depth understanding positive role

Language: Английский

Citations

5
Clinical and pharmacological research progress of &ldquo;three medicines and three formulae&rdquo; for COVID-19 treatment DOI
Jie Gao, Guangxu Xiao,

Guanwei Fan

et al.

Chinese Science Bulletin (Chinese Version), Journal Year: 2022, Volume and Issue: 67(27), P. 3296 - 3310

Published: May 27, 2022

Language: Английский

Citations

8
Identification of active compounds of traditional chinese medicine derived from maxing shigan decoction for COVID-19 treatment: a meta-analysis and in silico study DOI
Xiaodan Guo,

Yihua Lin,

Fengming He

et al.

Expert Review of Anti-infective Therapy, Journal Year: 2023, Volume and Issue: 21(8), P. 871 - 889

Published: July 23, 2023

ABSTRACTBackground Coronavirus 2019 (COVID-19) poses a serious threat to human health. In China, traditional Chinese medicine (TCM), mainly based on the Maxing Shigan decoction (MXSGD), is used in conjunction with western treat COVID-19.Research design and methods We conducted network meta-analysis investigate whether MXSGD-related TCM combined more effective treating COVID-19 compared alone. Additionally, using pharmacology, cross-docking, molecular dynamics (MD) simulation explore potential active compounds possible targets underlying therapeutic effects of TCM.Results was better for Network pharmacological analysis identified 43 shared ingredients prescriptions 599 common target genes. Cross-docking 154 proteins that matched these genes led identification 60 proteins. Pathway profiling revealed participated multiple signaling pathways contribute their efficacy. Molecular docking MD demonstrated MOL007214, most promising molecule, could stably bind site SARS-CoV-2 3CLpro.Conclusion This study demonstrates important role treatment COVID-19.KEYWORDS: Meta-analysismaxing shigan decoctionCOVID-19network pharmacologymolecular Declaration interestThe authors have no relevant affiliations or financial involvement any organization entity interest conflict subject matter materials discussed manuscript. includes employment, consultancies, honoraria, stock ownership options, expert testimony, grants patents received pending, royalties.Reviewer disclosuresPeer reviewers this manuscript other relationships disclose.Committee approval statementI confirm has from ethics committee at institution practice which stated If formal not granted reason should be explained manuscript.Supplementary materialSupplemental data article can accessed online https://doi.org/10.1080/14787210.2023.2238899Additional informationFundingSupport paper provided by Fujian Province Science Technology Project (2020Y0013), Ministry People's Republic National Natural Foundation China (82141215, 82173779, U1903119) Xiamen Municipal Bureau Planning (3502Z2021YJ11).

Language: Английский

Citations

3
Schisanhenol: A Potential Drug for the Treatment of Cytokine Storm DOI Open Access
Wenjun Qi, Dandan Shi,

Ruojia Zhang

et al.

Exploratory Research and Hypothesis in Medicine, Journal Year: 2023, Volume and Issue: 9(2), P. 93 - 101

Published: Dec. 13, 2023

Background and objectivesCytokine storm (CS) is an acute systemic inflammatory response with limited effective interventions up to now. The treatment experience of the COVID-19 pandemic suggests great potential in intervention CS by herbal medicine. This study aimed investigate whether Schisanhenol (SSH), active component Chinese medicine Schisandra chinensis, has interfere CS.

Language: Английский

Citations

1
A retrospective study of Reyanning mixture in elderly patients infected with SARS-CoV-2 Omicron variant DOI Creative Commons
Changya Liu, Xinxin Wu,

Hongqiang Yang

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: July 20, 2023

Objective: Reyanning mixture has been demonstrated to be effective in treating infected patients during the outbreak pandemic of SARS-CoV-2 Omicron variant Coronavirus disease 2019 (COVID-19) Shanghai 2022. The aim this study is further investigate role specifically treatment elderly patients. Methods: This enrolled 1,102 who were with variant. Of these, 291 received conjunction conventional Western medicine assigned group, while 811 only control group. Clinical parameters including hospitalization duration, viral shedding time, and Cycle Threshold (Ct) values novel coronavirus nucleic acid tests, as well adverse events recorded analyzed both groups. Results: There was no significant difference baseline characteristics between two In comparison group a substantial duration (median: 8 days vs. 10 days, HR: 0.638, 95% CI: 0.558-0.731, p < 0.001). also showed significantly shorter time compared 7 0.754, 0.659-0.863, Multivariate Cox proportional-hazards model analysis indicated that use closely associated reduction (HR: 1.562, 1.364-1.789, 0.001) 1.335, 1.166-1.528, addition, process, serious event occurred either Conclusion: improvement clinical indicate promising therapeutic benefit for present study. Further investigations are required validate finding by examining underlying mechanism function mixture.

Language: Английский

Citations

0