Solid lipid nanoparticles and nanostructured lipid carriers: a review of the methods of manufacture and routes of administration

Pharmaceutical Development and Technology, Journal Year: 2022, Volume and Issue: 27(5), P. 525 - 544

Published: May 28, 2022

The bioavailability of drugs is dependent on several factors such as solubility and the administration route. A drug with poor aqueous solubility, therefore, poses challenges regards to its pharmaceutical advance ultimately biological usage. Lipid nanoparticles have been used in science due their importance green chemistry. Their biochemical properties ‘green’ materials processes mean they can be environmentally sustainable. Generally, lipid employed carriers for both lipophilic hydrophilic drugs. proposed route present advantages disadvantages which should considered by a formulator. Solid (SLNs) nanostructured (NLCs) are attractive delivery systems because ease manufacture, biocompatibility, biodegradability, scale-up capacity formulation constituents. easy simple scalability novel SLNs nano carriers, along various processing procedures, recent developments, limitation toxicity, optimization approaches manufacture nanoparticles, lyophilization release comprehensively discussed this review. This review also summarizes research data related preparation methods excipients NLCs years.

Language: Английский

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Natural compounds-based nanomedicines for cancer treatment: Future directions and challenges

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(10), P. 2845 - 2916

Published: July 13, 2024

Abstract Several efforts have been extensively accomplished for the amelioration of cancer treatments using different types new drugs and less invasives therapies in comparison with traditional therapeutic modalities, which are widely associated numerous drawbacks, such as drug resistance, non-selectivity high costs, restraining their clinical response. The application natural compounds prevention treatment cells has attracted significant attention from pharmaceuticals scientific communities over past decades. Although use nanotechnology therapy is still preliminary stages, nanotherapeutics demonstrated to decrease various limitations related compounds, physical/chemical instability, poor aqueous solubility, low bioavailability. Despite emerged a promise improve bioavailability there limited trials performed challenges required pre-clinical trials, production at an industrial level, assurance long-term stability, physiological barriers safety regulatory issues. This review highlights most recent advances nanocarriers secreted plants, bacteria, fungi, marine organisms, well role on cell signaling pathways anticancer treatments. Additionally, status main regarding loaded applications were also discussed. Graphical abstract

Language: Английский

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Nanostructured lipid carriers (NLCs): A promising candidate for lung cancer targeting

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 655, P. 123986 - 123986

Published: March 15, 2024

Language: Английский

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Nano-Enabled Strategies for the Treatment of Lung Cancer: Potential Bottlenecks and Future Perspectives

Biomedicines, Journal Year: 2023, Volume and Issue: 11(2), P. 473 - 473

Published: Feb. 6, 2023

On a global scale, lung cancer is acknowledged to be the major driver of death attributable treatment challenges and poor prognosis. Classical regimens, such as chemotherapy or radiotherapy, can used treat cancer, but appended adverse effects limit them. Because numerous side associated with these modalities, it crucial strive develop novel better strategies for managing cancer. Attributes enhanced bioavailability, in vivo stability, intestinal absorption pattern, solubility, prolonged targeted distribution, superior therapeutic effectiveness anticancer drugs have all been boosted emergence nano-based systems. Lipid-based polymeric inorganic nano-formulations are now being explored delivery chemotherapeutics treatment. Nano-based approaches pioneering route primary metastatic diagnosis The implementation development innovative nanocarriers drug administration, particularly developing therapies, an intriguing challenging task scientific domain. current article provides overview methods, passive active targeting Combinatorial therapy techniques overcome resistance cells, potential ways increase effectiveness, also discussed. In addition, clinical studies therapies at different stages presented. A summary patent literature has included keep readers aware new nanotechnology-based

Language: Английский

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Smart Lipid‐Based Nanoparticles in Lung Cancer Treatment: Current Status and Future Directions

Advanced Therapeutics, Journal Year: 2023, Volume and Issue: 6(12)

Published: Sept. 12, 2023

Abstract Lung cancer remains the leading cause of cancer‐related deaths worldwide, and conventional treatments for disease often fall short. Smart nanoparticles (NPs) are emerging as a promising strategy treatment lung cancer, owing to their ability selectively deliver therapeutic agents cells while minimizing off‐target effects. NPs can respond specific stimuli such changes in pH, temperature, or enzymes, allowing them release cargo only when triggered. Among various types smart NPs, lipid‐based including liposomes, solid lipid nanoparticles, cubosomes, extracellular vesicles, have garnered highest interest due biocompatibility, low toxicity, versatility encapsulating wide variety drugs genetic material. This review discusses current status treatment, recent advances targeting strategies, stimuli‐responsive combination therapies. The challenges opportunities associated with translating into clinical applications also discussed. highlights potential revolutionize improve patient outcomes.

Language: Английский

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Recent advances in the use of liquid crystalline nanoparticles for non-small cell lung cancer treatment

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Introduction Non-small cell lung cancer (NSCLC) continues to pose a considerable health challenge with few therapeutic alternatives. Liquid crystalline nanoparticles (LCN) are nanostructured drug delivery systems made of lipid-based amphiphilic materials that self-assemble into phases in aqueous environments. LCN have become promising way treat NSCLC owing their specific properties make them useful for targeted and controlled release.

Language: Английский

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Moringa oleifera mediated green synthesis of gold nanoparticles and their anti-cancer activity against A549 cell line of lung cancer through ROS/ mitochondrial damage

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13

Published: March 5, 2025

Gold nanoparticles (Au-NPs) hold significant promise in lung cancer treatment due to their unique physicochemical properties, enabling targeted drug delivery, enhanced therapeutic efficacy, and reduced systemic toxicity. This study is aimed produce the Au-NPs utilising Moringa oleifera evaluate effectiveness of cancer, with a specific focus on A549 cell lines. The synthesis was carried out by combining 10 mL an aqueous extract M. 190 1 mM HAuCl4 solution. synthesized were characterised using several microscopic spectroscopic techniques. evaluation median inhibitory concentration (IC50) its impact apoptosis conducted through measurement caspase activation formation reactive oxygen species (ROS). Anti-cancer characteristics employing DAPI staining. Furthermore, influence ROS production mitochondrial membrane potential evaluated at IC50 fluorescence microscopy, DCFH-DA Rhodamine 123 dyes. confirmed UV-Vis spectroscopy, absorbance peak 540 nm. FTIR, TEM results showed that mediated had spherical morphology, mean size approximately 30 nm, as determined DLS. exhibited value 50 μg/mL against cells. staining revealed both concentrations AuNP, 25 μg/mL, noteworthy anti-cancer apoptotic properties. demonstrates oleifera-mediated exhibit cytotoxic effects cells, μg/mL. Both tested substantial specifically line, sets this apart from others address broader spectrum types. These findings suggest for clinical applications treatment, providing new application.

Language: Английский

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Oral Microbiota and Tumor—A New Perspective of Tumor Pathogenesis

Microorganisms, Journal Year: 2022, Volume and Issue: 10(11), P. 2206 - 2206

Published: Nov. 8, 2022

Microorganisms have long been known to play key roles in the initiation and development of tumors. The oral microbiota tumorigenesis linked epidemiological research relating molecular pathology. Notably, some bacteria can impact distal tumors by their gastrointestinal or blood-borne transmission under pathological circumstances. Certain drive progression through direct indirect immune system actions. This review systemically discusses recent advances field microecology tumor, including oncogenic role microbial abnormalities various potential carcinogenesis mechanisms (excessive inflammatory response, host immunosuppression, anti-apoptotic activity, carcinogen secretion) introduce future directions for effective tumor prevention.

Language: Английский

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Deciphering a crosstalk between biological cues and multifunctional nanocarriers in lung cancer therapy

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125395 - 125395

Published: March 1, 2025

Language: Английский

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Preparation of ferrocene‑iridium(III) acylhydrazone complexes and their anticancer application against A549 cell line

Journal of Inorganic Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 112899 - 112899

Published: March 1, 2025

Language: Английский

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