Cell Death and Disease,
Journal Year:
2023,
Volume and Issue:
14(2)
Published: Feb. 9, 2023
Abstract
Pyroptosis
is
a
recently
described
mechanism
of
programmed
cell
death
mediated
by
proteins
the
gasdermin
family.
Widely
recognized
signaling
cascades
include
classical,
non-classical,
caspase-3-dependent
E
and
caspase-8-dependent
D
pathways.
Additional
pyroptotic
pathways
have
been
subsequently
reported.
With
rising
prevalence
advanced
age,
role
pyroptosis
in
degenerative
diseases
elderly
has
attracted
increased
research
attention.
This
article
reviews
primary
mechanisms
summarizes
progress
such
as
presbycusis,
age-related
macular
degeneration,
Alzheimer’s
disease,
intervertebral
disc
osteoarthritis.
Immunity & Ageing,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: Feb. 5, 2024
The
gradual
aging
of
the
global
population
has
led
to
a
surge
in
age-related
diseases,
which
seriously
threaten
human
health.
Researchers
are
dedicated
understanding
and
coping
with
complexities
aging,
constantly
uncovering
substances
mechanism
related
like
chronic
low-grade
inflammation.
NOD-like
receptor
protein
3
(NLRP3),
key
regulator
innate
immune
response,
recognizes
molecular
patterns
associated
pathogens
injury,
initiating
an
intrinsic
inflammatory
response.
Dysfunctional
NLRP3
is
linked
onset
particularly
context
aging.
Therefore,
profound
comprehension
regulatory
mechanisms
inflammasome
aging-related
diseases
holds
potential
enhance
treatment
strategies
for
these
conditions.
In
this
article,
we
review
significance
initiation
progression
diverse
diseases.
Furthermore,
explore
preventive
therapeutic
by
manipulating
inflammasome,
along
its
upstream
downstream
mechanisms.
International Journal of Nanomedicine,
Journal Year:
2023,
Volume and Issue:
Volume 18, P. 2447 - 2463
Published: May 1, 2023
Introduction:
Benzalkonium
chloride
(BAC)
is
widely
employed
as
a
preservative
in
eye
drops,
which
will
cause
the
death
of
corneal
epithelial
cells
due
to
ROS
production,
DNA
strand
breakage,
and
mitochondrial
dysfunction,
resulting
dry
disease
(DED)-like
changes
ocular
surface
tissues.
In
this
study,
Melatonin
(MT)
liposomes
(TAT-MT-LIPs)
designed
by
loading
MT
into
TAT-modified
have
been
developed,
characterized,
used
for
inhibiting
BAC-induced
DED
(BAC-DED).
Methods:
The
TAT
was
chemically
grafted
onto
Mal-PEG
2000
-DSPE
Michael's
addition
between
sulfhydryl
group
maleimide
-DSPE.
TAT-MT-LIPs
were
prepared
using
film
dispersion
followed
extrusion
method
topically
treated
rats
once
day.
BAC-DED
induced
topical
administration
with
0.2%
BAC
twice
daily.
Defects,
edema,
inflammation
corneas,
well
IOP,
examined.
Histologic
analyses
corneas
performed
assess
change
oxidation
NLRP3/Caspase-1/GSDMD
signaling
transduction.
Results:
After
administration,
significantly
alleviated
DED-clinical
symptoms
experimental
animals
tissue
preventing
loss
epithelium
conjunctival
goblet
cells.
Our
data
suggested
continuous
exposure
mediated
pyroptosis,
not
reported
before.
caused
substantial
mt-DNA
oxidation,
promoted
transduction
consequent
pyroptosis.
could
efficiently
suppress
pyroptosis
subsequent
signal
transmission.
Conclusion:
involved
development
BAC-DED.
present
study
provided
new
insights
adverse
effects
BAC,
can
serve
target
protecting
when
applying
drops.
developed
inhibit
give
great
potential
be
treatment.
Keywords:
melatonin
liposome,
disease,
benzalkonium
chloride,
axis
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 22, 2024
Pyroptosis
is
an
innate
immune
response
triggered
by
the
activation
of
inflammasomes
various
influencing
factors,
characterized
cell
destruction.
It
impacts
system
and
cancer
immunotherapy.
In
recent
years,
roles
pyroptosis
in
intestinal
inflammation
have
been
continuously
confirmed.
This
article
reviews
latest
progress
mechanisms,
new
discoveries
inflammasomes,
mutual
regulation
between
their
applications
diseases.
Additionally,
potential
synergistic
treatment
mechanisms
diseases
with
are
summarized,
challenges
future
directions
discussed,
providing
ideas
for
therapy.
Neural Regeneration Research,
Journal Year:
2023,
Volume and Issue:
19(8), P. 1660 - 1670
Published: Nov. 8, 2023
Central
nervous
system
injuries
have
a
high
rate
of
resulting
in
disability
and
mortality;
however,
at
present,
effective
treatments
are
lacking.
Programmed
cell
death,
which
is
genetically
determined
form
active
ordered
death
with
many
types,
has
recently
attracted
increasing
attention
due
to
its
functions
determining
the
fate
survival.
A
growing
number
studies
suggested
that
programmed
involved
central
plays
an
important
role
progression
brain
damage.
In
this
review,
we
provide
overview
injuries,
including
pathways
mitophagy,
pyroptosis,
ferroptosis,
necroptosis,
underlying
mechanisms
by
mitophagy
regulates
necroptosis.
We
also
discuss
new
direction
therapeutic
strategies
targeting
for
treatment
aim
determine
connection
between
identify
therapies
modulate
following
injury.
conclusion,
based
on
these
properties
effects,
interventions
could
be
developed
as
potential
agents
injury
patients.
Biochemical Pharmacology,
Journal Year:
2022,
Volume and Issue:
203, P. 115168 - 115168
Published: July 12, 2022
Pathological
deterioration
of
mitochondrial
function
is
increasingly
linked
with
multiple
degenerative
illnesses
as
a
mediator
wide
range
neurologic
and
age-related
chronic
diseases,
including
those
genetic
origin.
Several
these
diseases
are
rare,
typically
defined
in
the
United
States
an
illness
affecting
fewer
than
200,000
people
U.S.
population,
or
about
one
1600
individuals.
Vision
impairment
due
to
dysfunction
eye
prominent
feature
evident
numerous
primary
common
pathophysiology
many
familiar
ophthalmic
disorders,
macular
degeneration,
diabetic
retinopathy,
glaucoma
retinopathy
prematurity
—
collection
syndromes,
disorders
significant
unmet
medical
needs.
Focusing
on
metabolic
pathway
mechanisms,
possible
roles
cuproptosis
ferroptosis
retinal
dysfunction,
we
shed
light
potential
α-lipoyl-L-carnitine
treating
diseases.
α-Lipoyl-L-carnitine
bioavailable
mitochondria-targeting
lipoic
acid
prodrug
that
has
shown
protecting
against
degeneration
photoreceptor
cell
loss
indications.
