Reduction of high glucose-induced oxidative injury in human retinal pigment epithelial cells by sarsasapogenin through inhibition of ROS generation and inactivation of NF-κB/NLRP3 inflammasome pathway DOI
Yung Hyun Choi

Genes & Genomics, Journal Year: 2023, Volume and Issue: 45(9), P. 1153 - 1163

Published: June 24, 2023

Language: Английский

Pyroptosis and degenerative diseases of the elderly DOI Creative Commons
Jiamin Zhou,

Jingjing Qiu,

Yuwan Song

et al.

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(2)

Published: Feb. 9, 2023

Abstract Pyroptosis is a recently described mechanism of programmed cell death mediated by proteins the gasdermin family. Widely recognized signaling cascades include classical, non-classical, caspase-3-dependent E and caspase-8-dependent D pathways. Additional pyroptotic pathways have been subsequently reported. With rising prevalence advanced age, role pyroptosis in degenerative diseases elderly has attracted increased research attention. This article reviews primary mechanisms summarizes progress such as presbycusis, age-related macular degeneration, Alzheimer’s disease, intervertebral disc osteoarthritis.

Language: Английский

Citations

47

The role of NLRP3 inflammasome in aging and age-related diseases DOI Creative Commons
Ruikai Liang, Xinrui Qi, Qi Cai

et al.

Immunity & Ageing, Journal Year: 2024, Volume and Issue: 21(1)

Published: Feb. 5, 2024

The gradual aging of the global population has led to a surge in age-related diseases, which seriously threaten human health. Researchers are dedicated understanding and coping with complexities aging, constantly uncovering substances mechanism related like chronic low-grade inflammation. NOD-like receptor protein 3 (NLRP3), key regulator innate immune response, recognizes molecular patterns associated pathogens injury, initiating an intrinsic inflammatory response. Dysfunctional NLRP3 is linked onset particularly context aging. Therefore, profound comprehension regulatory mechanisms inflammasome aging-related diseases holds potential enhance treatment strategies for these conditions. In this article, we review significance initiation progression diverse diseases. Furthermore, explore preventive therapeutic by manipulating inflammasome, along its upstream downstream mechanisms.

Language: Английский

Citations

24

Pyroptosis as a double-edged sword: The pathogenic and therapeutic roles in inflammatory diseases and cancers DOI

Zuohao Liu,

Chunming Wang, Changjun Lin

et al.

Life Sciences, Journal Year: 2023, Volume and Issue: 318, P. 121498 - 121498

Published: Feb. 11, 2023

Language: Английский

Citations

32

Suppression of NLRP3/Caspase-1/GSDMD Mediated Corneal Epithelium Pyroptosis Using Melatonin-Loaded Liposomes to Inhibit Benzalkonium Chloride-Induced Dry Eye Disease DOI Creative Commons

Qi Lou,

Lu Pan, Shengjin Xiang

et al.

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 2447 - 2463

Published: May 1, 2023

Introduction: Benzalkonium chloride (BAC) is widely employed as a preservative in eye drops, which will cause the death of corneal epithelial cells due to ROS production, DNA strand breakage, and mitochondrial dysfunction, resulting dry disease (DED)-like changes ocular surface tissues. In this study, Melatonin (MT) liposomes (TAT-MT-LIPs) designed by loading MT into TAT-modified have been developed, characterized, used for inhibiting BAC-induced DED (BAC-DED). Methods: The TAT was chemically grafted onto Mal-PEG 2000 -DSPE Michael's addition between sulfhydryl group maleimide -DSPE. TAT-MT-LIPs were prepared using film dispersion followed extrusion method topically treated rats once day. BAC-DED induced topical administration with 0.2% BAC twice daily. Defects, edema, inflammation corneas, well IOP, examined. Histologic analyses corneas performed assess change oxidation NLRP3/Caspase-1/GSDMD signaling transduction. Results: After administration, significantly alleviated DED-clinical symptoms experimental animals tissue preventing loss epithelium conjunctival goblet cells. Our data suggested continuous exposure mediated pyroptosis, not reported before. caused substantial mt-DNA oxidation, promoted transduction consequent pyroptosis. could efficiently suppress pyroptosis subsequent signal transmission. Conclusion: involved development BAC-DED. present study provided new insights adverse effects BAC, can serve target protecting when applying drops. developed inhibit give great potential be treatment. Keywords: melatonin liposome, disease, benzalkonium chloride, axis

Language: Английский

Citations

24

Pyroptosis: a new insight into intestinal inflammation and cancer DOI Creative Commons

Limin Chao,

Wenjing Zhang,

Yuchao Feng

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 22, 2024

Pyroptosis is an innate immune response triggered by the activation of inflammasomes various influencing factors, characterized cell destruction. It impacts system and cancer immunotherapy. In recent years, roles pyroptosis in intestinal inflammation have been continuously confirmed. This article reviews latest progress mechanisms, new discoveries inflammasomes, mutual regulation between their applications diseases. Additionally, potential synergistic treatment mechanisms diseases with are summarized, challenges future directions discussed, providing ideas for therapy.

Language: Английский

Citations

10

DTX3L induced NLRP3 ubiquitination inhibit R28 cell pyroptosis in OGD/R injury DOI Creative Commons

Ziyu Zhou,

Lei Shang, Qí Zhāng

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2023, Volume and Issue: 1870(3), P. 119433 - 119433

Published: Jan. 25, 2023

Language: Английский

Citations

21

Effects of TCPP and TCEP exposure on human corneal epithelial cells: Oxidative damage, cell cycle arrest, and pyroptosis DOI
Zhen-Ning Zhang,

Dan-Lei Yang,

Liu Hai

et al.

Chemosphere, Journal Year: 2023, Volume and Issue: 331, P. 138817 - 138817

Published: April 29, 2023

Language: Английский

Citations

20

Crosstalk among mitophagy, pyroptosis, ferroptosis, and necroptosis in central nervous system injuries DOI Creative Commons
Li Zhang, Zhigang Hu, Zhenxing Li

et al.

Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(8), P. 1660 - 1670

Published: Nov. 8, 2023

Central nervous system injuries have a high rate of resulting in disability and mortality; however, at present, effective treatments are lacking. Programmed cell death, which is genetically determined form active ordered death with many types, has recently attracted increasing attention due to its functions determining the fate survival. A growing number studies suggested that programmed involved central plays an important role progression brain damage. In this review, we provide overview injuries, including pathways mitophagy, pyroptosis, ferroptosis, necroptosis, underlying mechanisms by mitophagy regulates necroptosis. We also discuss new direction therapeutic strategies targeting for treatment aim determine connection between identify therapies modulate following injury. conclusion, based on these properties effects, interventions could be developed as potential agents injury patients.

Language: Английский

Citations

20

The central role of the NLRP3 inflammasome pathway in the pathogenesis of age-related diseases in the eye and the brain DOI
Jack Jonathan Maran,

Moradeke M. Adesina,

Colin Green

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 88, P. 101954 - 101954

Published: May 15, 2023

Language: Английский

Citations

19

Treatment and prevention of pathological mitochondrial dysfunction in retinal degeneration and in photoreceptor injury DOI Creative Commons
Walter H. Moos, Douglas V. Faller,

Ioannis P. Glavas

et al.

Biochemical Pharmacology, Journal Year: 2022, Volume and Issue: 203, P. 115168 - 115168

Published: July 12, 2022

Pathological deterioration of mitochondrial function is increasingly linked with multiple degenerative illnesses as a mediator wide range neurologic and age-related chronic diseases, including those genetic origin. Several these diseases are rare, typically defined in the United States an illness affecting fewer than 200,000 people U.S. population, or about one 1600 individuals. Vision impairment due to dysfunction eye prominent feature evident numerous primary common pathophysiology many familiar ophthalmic disorders, macular degeneration, diabetic retinopathy, glaucoma retinopathy prematurity — collection syndromes, disorders significant unmet medical needs. Focusing on metabolic pathway mechanisms, possible roles cuproptosis ferroptosis retinal dysfunction, we shed light potential α-lipoyl-L-carnitine treating diseases. α-Lipoyl-L-carnitine bioavailable mitochondria-targeting lipoic acid prodrug that has shown protecting against degeneration photoreceptor cell loss indications.

Language: Английский

Citations

23