International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 155 - 169
Published: Jan. 1, 2024
Background:
Targeted
delivery
systems
have
been
developed
to
improve
cancer
treatment
by
reducing
side
effects
and
enhancing
drug
efficacy.
Geraniol,
a
natural
product,
has
demonstrated
promising
anti-cancer
in
various
types,
including
prostate
cancer,
which
is
the
most
commonly
diagnosed
men.
Hyaluronic
acid
(HA),
carrier
targeting
CD44-positive
cells,
can
be
utilized
targeted
system.
Purpose:
This
study
investigated
efficacy
of
conjugate
HA
geraniol
linked
via
disulfide
bond
linker
(HA-SS-Geraniol)
cancer.
Materials
Methods:
The
cytotoxicity
HA-SS-Geraniol
was
evaluated
on
human
PC-3
cells.
Flow
cytometry
used
assess
its
mitochondrial
membrane
potential,
apoptosis,
cell
cycle
arrest.
Additionally,
proteomic
analysis
conducted
explore
underlying
mechanism
action
induced
treatment.
A
subcutaneous
xenograft
tumor
model
established
nude
mice
evaluate
toxicity
vivo.
Results:
results
that
exhibited
potent
against
cells
inducing
potential
loss
apoptosis
vitro.
further
supported
hypothesis
induces
death
through
mitochondria-mediated
as
evidenced
differential
protein
expression.
vivo
mouse
confirmed
safety
ability
inhibit
growth.
Conclusion:
holds
promise
biologically
safe
potentially
effective
therapeutic
agent
for
Its
system
utilizing
shows
improving
therapy.
Keywords:
geraniol,
hyaluronic
acid,
nanoparticle,
proteomics
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: March 20, 2025
Ovarian
cancer
is
one
the
deadliest
disease
wherein
survival
rate
very
low.
Despite
of
advances
in
medical
sciences,
researches
are
still
at
stage
infancy
where
patients
succumbing
to
this
malignancy.
Multidrug
resistance,
toxicity,
mode
treatment
related
issues
like
catheter
complication
poises
a
number
challenges
scientists
worldwide.
Novel
therapy
now
thus
being
focussed
sensitive
cells
more
towards
treatment.
Gold
nanoparticles
(Au
NPs),
known
for
their
high
biocompatibility,
and
strong
optical
magnetic
responses,
have
emerged
as
promising
agents
both
diagnosis
ovarian
cancer.
Owing
physical
characteristics,
AuNPs
may
be
used
adjuvants
bioimaging,
radiotherapy
fluorescence
imaging.
As
result,
these
characteristics
substantially
support
biological
domains.
In
addition
therapeutic
potential,
Au
NPs
exhibit
surface
plasmon
resonance
(SPR)
properties,
enhancing
imaging
techniques
early
detection
tumors.
Furthermore,
chemical
properties
such
Magnetic
Resonance
Imaging
Properties,
X-ray
property,
Two-photon
or
multiphoton
imaging,
Optical
coherence
tomography
(OCT)
enhance
use
diagnosis.
This
paper
highlights
targeting
potential
by
has
been
discussed.
Journal of Materials Chemistry B,
Journal Year:
2023,
Volume and Issue:
12(4), P. 872 - 894
Published: Dec. 11, 2023
This
review
delves
into
the
potential
of
zeolitic
imidazolate
framework-8
(ZIF-8)
nanoparticles
in
augmenting
efficacy
cancer
immunotherapy,
with
a
special
focus
on
delivery
programmed
cell
death
receptor
1
(PD-1)
inhibitors.
The
multifunctional
nature
ZIF-8
as
drug
carriers
is
emphasized,
their
ability
to
encapsulate
range
therapeutic
agents,
including
PD-1
inhibitors,
and
facilitate
targeted
tumor
locations.
By
manipulating
pore
size
surface
characteristics
nanoparticles,
controlled
release
can
be
realized.
strategic
use
deliver
inhibitors
presents
precise
modality
for
treatment,
reducing
off-target
impacts
enhancing
effectiveness.
combined
strategy
addresses
existing
challenges
constraints
current
immunotherapy
techniques,
ultimate
goal
patient
outcomes
therapy.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 155 - 169
Published: Jan. 1, 2024
Background:
Targeted
delivery
systems
have
been
developed
to
improve
cancer
treatment
by
reducing
side
effects
and
enhancing
drug
efficacy.
Geraniol,
a
natural
product,
has
demonstrated
promising
anti-cancer
in
various
types,
including
prostate
cancer,
which
is
the
most
commonly
diagnosed
men.
Hyaluronic
acid
(HA),
carrier
targeting
CD44-positive
cells,
can
be
utilized
targeted
system.
Purpose:
This
study
investigated
efficacy
of
conjugate
HA
geraniol
linked
via
disulfide
bond
linker
(HA-SS-Geraniol)
cancer.
Materials
Methods:
The
cytotoxicity
HA-SS-Geraniol
was
evaluated
on
human
PC-3
cells.
Flow
cytometry
used
assess
its
mitochondrial
membrane
potential,
apoptosis,
cell
cycle
arrest.
Additionally,
proteomic
analysis
conducted
explore
underlying
mechanism
action
induced
treatment.
A
subcutaneous
xenograft
tumor
model
established
nude
mice
evaluate
toxicity
vivo.
Results:
results
that
exhibited
potent
against
cells
inducing
potential
loss
apoptosis
vitro.
further
supported
hypothesis
induces
death
through
mitochondria-mediated
as
evidenced
differential
protein
expression.
vivo
mouse
confirmed
safety
ability
inhibit
growth.
Conclusion:
holds
promise
biologically
safe
potentially
effective
therapeutic
agent
for
Its
system
utilizing
shows
improving
therapy.
Keywords:
geraniol,
hyaluronic
acid,
nanoparticle,
proteomics
