Microvesicles derived from mesenchymal stem cells: A promising therapeutic strategy for acute respiratory distress syndrome-related pulmonary fibrosis? DOI
Zhao Zhang,

X. Y. Shan,

Ce Liang

et al.

World Journal of Stem Cells, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 17, 2025

Pulmonary fibrosis significantly contributes to the pathogenesis of acute respiratory distress syndrome (ARDS), markedly increasing patient mortality. Despite established anti-fibrotic effects mesenchymal stem cells (MSCs), numerous challenges hinder their clinical application. A recent study demonstrated that microvesicles (MVs) from MSCs (MSC-MVs) could attenuate ARDS-related pulmonary and enhance lung function via hepatocyte growth factor mRNA transcription. This discovery presents a promising strategy for managing ARDS-associated fibrosis. article initially examines safety efficacy both basic science perspectives, subsequently exploring potential obstacles employing MSC-MVs as novel therapeutic approach. Additionally, it provides perspectives on future research into application in

Language: Английский

Hepatocellular carcinoma: signaling pathways, targeted therapy, and immunotherapy DOI Creative Commons
Xiaoting Luo, Xin He, Xingmei Zhang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(2)

Published: Feb. 1, 2024

Abstract Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a high mortality rate. It regarded as significant public health issue because of its complicated pathophysiology, metastasis, and recurrence rates. There are no obvious symptoms in early stage HCC, which often leads to delays diagnosis. Traditional treatment methods such surgical resection, radiotherapy, chemotherapy, interventional therapies have limited therapeutic effects for HCC patients or metastasis. With development molecular biology immunology, signaling pathways immune checkpoint were identified main mechanism progression. Targeting these molecules has become new direction HCC. At present, combination targeted drugs inhibitors first choice advanced patients. In this review, we mainly focus on cutting‐edge research corresponding therapy immunotherapy great significance comprehensively understand pathogenesis search potential targets, optimize strategies

Language: Английский

Citations

36
Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics DOI Creative Commons
Xiao Ma, Tengda Huang, Xi Chen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 8, 2025

Language: Английский

Citations

5
The Molecular Mechanism Underlying the Therapeutic Effect of Dihydromyricetin on Type 2 Diabetes Mellitus Based on Network Pharmacology, Molecular Docking, and Transcriptomics DOI Creative Commons

Xinnian Wen,

Chenghao Lv,

Runze Zhou

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(2), P. 344 - 344

Published: Jan. 22, 2024

Type 2 diabetes mellitus (T2DM) is a chronic and complex disease, traditional drugs have many side effects. The active compound dihydromyricetin (DHM), derived from natural plants, has been shown in our previous study to possess the potential for reducing blood glucose levels; however, its precise molecular mechanism remains unclear. In present study, network pharmacology transcriptomics were performed screen targets signaling pathways of DHM disturbed associated with T2DM, results partially verified by docking, RT-PCR, Western blotting at vivo levels. Firstly, effect on glucose, lipid profile, liver oxidative stress db/db mice was explored showed that could reduce improve liver. Secondly, GO analysis based mainly played significant role anti-inflammatory, antioxidant, fatty acid metabolism biological processes, lipoprotein respiratory chain cell components, redox-related enzyme activity, iron ion binding, glutathione transferase functional processes. KEGG system PI3K-Akt pathway, IL17 HIF MAPK AGE-RAGE pathway diabetic complications, TNF typical T2DM. Thirdly, docking VEGFA, SRC, HIF1A, ESR1, KDR, MMP9, PPARG, MAPK14 are key target genes, five genes which RT-PCR dose-dependent manner. Finally, revealed effectively upregulated expression AKT protein downregulated MEK mice. Therefore, found therapeutic activation PI3K/AKT/MAPK pathway. This establishes foundation as novel agent Additionally, it presents fresh approach utilizing plant extracts chemoprevention treatment

Language: Английский

Citations

11
Study on gene expression in the liver at various developmental stages of human embryos DOI Creative Commons

Hanqing Chen,

Tingting Li, Ming Cai

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 8, 2025

The normal development of the liver during human embryonic stages is critical for functionality adult liver. Despite this, essential genes, biological processes, and signal pathways that drive in embryos remain poorly understood. In this study, samples were collected from at progressive developmental stages, ranging 2-month-old to 7-month-old. Highly expressed genes their associated enrichment processes various identified through transcriptomic sequencing. findings indicated with humoral immune responses B-cell-mediated immunity highly early stages. Concurrently, numerous related vitamin response, brown adipocyte differentiation, T cell hormone secretion, hemostasis, peptide steroid metabolism, hematopoietic regulation exhibited increased expression aligned development. Our results suggest may possess multiple functions beyond serving roles. Moreover, study elucidated complex regulatory interactions among involved lymphocyte hemopoiesis, Consequently, necessitates synergistic genes. Notably, alongside conventionally recognized previously uncharacterized function also identified. These establish a foundation future research on diseases arising fetal abnormalities.

Language: Английский

Citations

1
The Icarian flight of antibody-drug conjugates: target selection amidst complexity and tackling adverse impacts DOI Creative Commons
Han Liu, Hongye Zeng, Xiaojing Qin

et al.

Protein & Cell, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract Antibody-drug conjugates (ADCs) represent a promising class of targeted cancer therapeutics that combine the specificity monoclonal antibodies with potency cytotoxic payloads. Despite their therapeutic potential, use ADCs faces significant challenges, including off/on-target toxicity and resistance development. This review examines current landscape ADC development, focusing on critical aspects target selection antibody engineering. We discuss strategies to increase efficacy safety, multitarget approaches, pH-dependent antibodies, masked peptide technologies. The importance comprehensive antigen expression profiling in both tumor normal tissues is emphasized, highlighting role advanced technologies, such as single-cell sequencing artificial intelligence (AI), optimizing selection. Furthermore, we explore combination therapies innovations linker‒payload chemistry, which may provide approaches for expanding window ADCs. These advances pave way development more precise effective treatments, potentially extending applications beyond oncology.

Language: Английский

Citations

1
AAV9-HGF cooperating with TGF-beta/Smad inhibitor attenuates silicosis fibrosis via inhibiting ferroptosis DOI Open Access

Rui Bao,

Qiushi Wang, Mengxue Yu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 161, P. 114537 - 114537

Published: March 16, 2023

Silicosis is a devastating interstitial lung disease characterized by silicon nodules and diffuse pulmonary fibrosis. To date, inefficient therapy still challenge of this due to its complicated pathogenesis. Hepatocyte growth factor (HGF) which highly expressed in hepatocyte with anti-fibrotic anti-apoptotic function was downregulated silicosis. In addition, the upregulation transforming factor-beta (TGF-β), another pathological molecular observed aggravate severity accelerate progression Here AAV HGF targeting capillaries SB431542, inhibitor TGF-β signal pathway, were simultaneously adopted synergistically reduce silicosis vivo result demonstrated that cooperation SB431542 showed strong anti-fibrosis effects on mice via tracheal administration silica, compared separate treatment. The high efficacy mainly achieved remarkably reducing ferroptosis tissue. our point, combination AAV9-HGF provide an alternative relieve fibrosis from perspective capillaries.

Language: Английский

Citations

23
Targeting collagen homeostasis for the treatment of liver fibrosis: Opportunities and challenges DOI Creative Commons
Theerut Luangmonkong, Warisara Parichatikanond, Peter Olinga

et al.

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 215, P. 115740 - 115740

Published: Aug. 10, 2023

Liver fibrosis is an excessive production, aberrant deposition, and deficit degradation of extracellular matrix (ECM). Patients with unresolved ultimately undergo end-stage liver diseases. To date, the effective safe strategy to cease progression remains unmet clinical need. Since collagens are most abundant ECM protein which play essential role in fibrogenesis, suitable regulation collagen homeostasis could be for treatment fibrosis. Therefore, this review provides a brief overview on dysregulation homeostasis, focusing collagens, pathogenesis Most importantly, promising therapeutic mechanisms related biosynthesis, deposition interactions, together preclinical antifibrotic evidence drugs affecting each target orderly criticized. In addition, challenges targeting discussed.

Language: Английский

Citations

20
Antibody–drug conjugates in cancer therapy: mechanisms and clinical studies DOI Creative Commons
Jun He,

Xianghua Zeng,

Chunmei Wang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 28, 2024

Abstract Antibody–drug conjugates (ADCs) consist of monoclonal antibodies that target tumor cells and cytotoxic drugs linked through linkers. By leveraging antibodies’ targeting properties, ADCs deliver into via endocytosis after identifying the antigen. This precise method aims to kill selectively while minimizing harm normal cells, offering safe effective therapeutic benefits. Recent years have seen significant progress in antitumor treatment with ADC development, providing patients new potent options. With over 300 explored for various indications some already approved clinical use, challenges such as resistance due factors like antigen expression, processing, payload emerged. review outline history their structure, mechanism action, recent composition advancements, selection, completed ongoing trials, mechanisms, intervention strategies. Additionally, it will delve potential novel markers, linkers, payloads, innovative action mechanisms enhance cancer The evolution has also led emergence combination therapy a approach improve drug efficacy.

Language: Английский

Citations

7
The role of gut microbiota in liver regeneration DOI Creative Commons
Zhe Xu, Nan Jiang, Yuanyuan Xiao

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 27, 2022

The liver has unique regeneration potential, which ensures the continuous dependence of human body on hepatic functions. As composition and function gut microbiota been gradually elucidated, vital role in through gut-liver axis recently accepted. In process regeneration, is changed. Moreover, can contribute to regulation immune microenvironment, thereby modulating release inflammatory factors including IL-6, TNF-α, HGF, IFN-γ TGF-β, involve different phases regeneration. And previous research have demonstrated that enterohepatic circulation, bile acids (BAs), lipopolysaccharide, short-chain fatty other metabolites associate with may promote various pathways. this perspective, by summarizing microbiota-derived signaling pathways we unveil provide feasible strategies altering composition.

Language: Английский

Citations

24
Interleukin-6 in Hepatocellular Carcinoma: A Dualistic Point of View DOI Creative Commons
Iuliana Nenu,

Teodora Maria Toadere,

Ioan Topor

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(10), P. 2623 - 2623

Published: Sept. 24, 2023

Hepatocellular Carcinoma (HCC) is a pressing health concern, demanding deep understanding of various mediators’ roles in its development for therapeutic progress. Notably, interleukin-6 (IL-6) has taken center stage investigations due to intricate and context-dependent functions. This review delves into the dual nature IL-6 HCC, exploring seemingly contradictory as both promoter an inhibitor disease progression. We dissect pro-tumorigenic effects IL-6, including impact on tumor growth, angiogenesis, metastasis. Concurrently, we examine anti-tumorigenic attributes, such role immune response activation, cellular senescence induction, surveillance. Through comprehensive exploration interactions between microenvironment, this highlights need nuanced comprehension signaling HCC. It underscores importance tailored strategies that consider dynamic stages diverse surroundings within microenvironment. Future research directions aimed at unraveling multifaceted mechanisms HCC hold promise developing more effective treatment improving patient outcomes.

Language: Английский

Citations

16