World Journal of Stem Cells,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Jan. 17, 2025
Pulmonary
fibrosis
significantly
contributes
to
the
pathogenesis
of
acute
respiratory
distress
syndrome
(ARDS),
markedly
increasing
patient
mortality.
Despite
established
anti-fibrotic
effects
mesenchymal
stem
cells
(MSCs),
numerous
challenges
hinder
their
clinical
application.
A
recent
study
demonstrated
that
microvesicles
(MVs)
from
MSCs
(MSC-MVs)
could
attenuate
ARDS-related
pulmonary
and
enhance
lung
function
via
hepatocyte
growth
factor
mRNA
transcription.
This
discovery
presents
a
promising
strategy
for
managing
ARDS-associated
fibrosis.
article
initially
examines
safety
efficacy
both
basic
science
perspectives,
subsequently
exploring
potential
obstacles
employing
MSC-MVs
as
novel
therapeutic
approach.
Additionally,
it
provides
perspectives
on
future
research
into
application
in
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6604 - 6604
Published: June 15, 2024
Hepatic
ischemia/reperfusion
injury
(IRI)
is
an
important
factor
affecting
liver
regeneration
and
functional
recovery
postoperatively.
Many
studies
have
suggested
that
mesenchymal
stem
cells
(MSCs)
contribute
to
hepatic
tissue
repair
through
paracrine
mechanisms
mediated
by
exosomes.
Minipigs
exhibit
much
more
similar
characteristics
of
the
those
humans
than
rodents.
This
study
aimed
explore
whether
exosomes
from
adipose-derived
MSCs
(ADSCs-exo)
could
actively
promote
after
hepatectomy
combined
with
HIRI
in
minipigs
role
they
play
cell
proliferation
process.
also
compared
effects
differences
ADSCs
ADSCs-exo
inflammatory
response
regeneration.
The
results
showed
suppressed
histopathological
changes
reduced
infiltration
liver;
significantly
decreased
levels
ALT,
TBIL,
HA,
pro-inflammatory
cytokines
TNF-α,
IL-6,
CRP;
increased
anti-inflammatory
cytokine
IL-10
pro-regeneration
factors
Ki67,
PCNA,
CyclinD1,
HGF,
STAT3,
VEGF,
ANG1,
ANG2;
anti-regeneration
SOCS3
TGF-β.
These
indicators
above
intervention
group.
Indicating
can
exert
same
as
regulating
responses
promoting
Our
findings
provide
experimental
evidence
for
possibility
be
considered
a
safe
effective
cell-free
therapy
injured
livers.
Biochemical Pharmacology,
Journal Year:
2024,
Volume and Issue:
227, P. 116437 - 116437
Published: July 16, 2024
The
normal
liver
has
an
extraordinary
capacity
of
regeneration.
However,
this
is
significantly
impaired
in
steatotic
livers.
Emerging
evidence
indicates
that
metabolic
dysfunction
associated
disease
(MASLD)
and
regeneration
share
several
key
mechanisms.
Some
classical
pathways,
such
as
HGF/c-Met,
EGFR,
Wnt/β-catenin
Hippo/YAP-TAZ
are
affected
MASLD.
recently
established
therapeutic
targets
for
MASH
the
Thyroid
Hormone
(TH)
receptors,
Glucagon-like
protein
1
(GLP1),
Farnesoid
X
receptor
(FXR),
Peroxisome
Proliferator-Activated
Receptors
(PPARs)
well
Fibroblast
Growth
Factor
21
(FGF21)
also
reported
to
affect
hepatocyte
proliferation.
With
review
we
aim
provide
insight
into
common
molecular
may
ultimately
enable
strategies
synergistically
ameliorate
steatohepatitis
improve
regenerating
recent
rise
prolonged
ex-vivo
normothermic
perfusion
prior
organ
transplantation
treatment
no
longer
restricted
patients
undergoing
major
resection
or
transplantation,
but
eventually
include
perfused
(steatotic)
donor
livers
even
segments,
opening
hitherto
unexplored
avenues.
World Journal of Stem Cells,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Jan. 17, 2025
Pulmonary
fibrosis
significantly
contributes
to
the
pathogenesis
of
acute
respiratory
distress
syndrome
(ARDS),
markedly
increasing
patient
mortality.
Despite
established
anti-fibrotic
effects
mesenchymal
stem
cells
(MSCs),
numerous
challenges
hinder
their
clinical
application.
A
recent
study
demonstrated
that
microvesicles
(MVs)
from
MSCs
(MSC-MVs)
could
attenuate
ARDS-related
pulmonary
and
enhance
lung
function
via
hepatocyte
growth
factor
mRNA
transcription.
This
discovery
presents
a
promising
strategy
for
managing
ARDS-associated
fibrosis.
article
initially
examines
safety
efficacy
both
basic
science
perspectives,
subsequently
exploring
potential
obstacles
employing
MSC-MVs
as
novel
therapeutic
approach.
Additionally,
it
provides
perspectives
on
future
research
into
application
in
