Frontiers in Endocrinology,
Journal Year:
2022,
Volume and Issue:
13
Published: Sept. 21, 2022
The
incidence
of
sporadic
Alzheimer's
disease
(AD)
is
increasing
in
recent
years.
Studies
have
shown
that
addition
to
some
genetic
abnormalities,
the
majority
AD
patients
has
a
history
long-term
exposure
risk
factors.
Neuroendocrine
related
factors
been
proved
be
strongly
associated
with
AD.
Long-term
hormone
disorder
can
direct
detrimental
effect
on
brain
by
producing
an
AD-like
pathology
and
result
cognitive
decline
impairing
neuronal
metabolism,
plasticity
survival.
Traditional
Chinese
Medicine(TCM)
may
regulate
complex
process
endocrine
disorders,
improve
metabolic
as
well
resulting
neuroinflammation
oxidative
damage
through
variety
pathways.
TCM
unique
therapeutic
advantages
treating
early
intervention
AD-related
neuroendocrine
disorders
preventing
decline.
This
paper
reviewed
relationship
between
treatment
its
mechanism.
pending
problems
was
also
discussed,
new
insights
for
dementia
future
provided.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(4), P. 4047 - 4047
Published: Feb. 17, 2023
Gut
microbiota
(GM),
the
microorganisms
in
gastrointestinal
tract,
contribute
to
regulation
of
brain
homeostasis
through
bidirectional
communication
between
gut
and
brain.
GM
disturbance
has
been
discovered
be
related
various
neurological
disorders,
including
Alzheimer's
disease
(AD).
Recently,
microbiota-gut-brain
axis
(MGBA)
emerged
as
an
enticing
subject
not
only
understand
AD
pathology
but
also
provide
novel
therapeutic
strategies
for
AD.
In
this
review,
general
concept
MGBA
its
impacts
on
development
progression
are
described.
Then,
diverse
experimental
approaches
studying
roles
pathogenesis
presented.
Finally,
MGBA-based
discussed.
This
review
provides
concise
guidance
those
who
wish
obtain
a
conceptual
methodological
understanding
relationship
with
emphasis
practical
application.
Naunyn-Schmiedeberg s Archives of Pharmacology,
Journal Year:
2024,
Volume and Issue:
397(6), P. 3781 - 3802
Published: Jan. 2, 2024
Tianma
is
the
dried
tuber
of
Gastrodia
elata
Blume
(G.
elata),
which
frequently
utilized
in
clinical
practice
as
a
traditional
Chinese
medicine.
Gastrodin
(GAS)
main
active
ingredient
Tianma,
has
good
pharmacological
activity.
Therefore,
for
first
time,
this
review
focused
on
extraction,
synthesis,
effects,
and
derivatives
GAS
to
investigate
additional
development
options
GAS.
The
use
microorganisms
create
promising
method.
efficacy
treatment
neurological
diseases,
cardiovascular
endocrine
liver
diseases.
significant
anti-inflammatory,
antioxidant,
neuroprotective,
vascular
protective,
blood
sugar
lowering,
lipid-regulating,
analgesic,
anticancer,
antiviral
effects.
mechanism
involves
various
signaling
pathways
such
Nrf2,
NF-κB,
PI3K/AKT,
AMPK.
In
addition,
biomaterials
synthesized
by
PU
suggested
broader
application
research
thoroughly
summarized
paper,
useful
applications
tackling
variety
disorders
exhibits
value.
Behavioural Brain Research,
Journal Year:
2024,
Volume and Issue:
465, P. 114968 - 114968
Published: March 22, 2024
Depression
is
a
psychiatric
disorder
and
the
treatment
of
depression
an
urgent
problem
that
need
to
be
solved.
Gastrodin
(GAS)
Traditional
Chinese
Medicine
from
orchid
used
for
neurological
diseases,
including
depressive
disorders.
To
assess
effect
GAS
on
gut
microbiota
mice,
we
established
chronic
unpredictable
mild
stress
(CUMS)-induced
mouse
model,
was
administered
one
group
mice.
Animal
behavior
experiments
were
detect
depressive-like
behaviors,
16
S
rRNA
gene
analysis
applied
each
group.
All
raw
sequences
deposited
in
NCBI
Sequence
Read
Archive
under
accession
number
SRP491061.
significantly
improved
behaviors
as
well
diversity
abundance
microbiota.
The
CUMS-GAS
different
degrees
compared
with
CUMS
linear
discriminant
(LDA)
showed
makeup
mice
changed
dramatically
group,
Bacteroides
(LDA
=
3.94,
P
<
0.05)
enriched
at
genus
level.
In
comparison
had
greater
concentration
numbers
Lactobacillus,
Corynebacterium,
Staphylococcus,
Bacteroides,
Psychrobacter,
Alistipes.
Our
results
suggested
impacted
microbial
composition
gut.
research
indicated
dysbiosis
may
affected
by
treatment,
which
CUMS-induced
model
depression.
Biochemical and Biophysical Research Communications,
Journal Year:
2024,
Volume and Issue:
719, P. 150127 - 150127
Published: May 15, 2024
Alzheimer's
disease
is
characterized
by
abnormal
β-amyloid
and
tau
accumulation,
mitochondrial
dysfunction,
oxidative
stress,
synaptic
dysfunction.
Here,
we
aimed
to
assess
the
mechanisms
signalling
pathways
in
neuroprotective
effect
of
gastrodin,
a
phenolic
glycoside,
on
murine
neuroblastoma
N2a
cells
expressing
human
Swedish
mutant
APP
(N2a/APP).
We
found
that
gastrodin
increased
levels
presynaptic-SNAP,
synaptophysin,
postsynaptic-PSD95
reduced
phospho-tau
Ser396,
Aβ
Small,
Journal Year:
2024,
Volume and Issue:
20(47)
Published: Aug. 26, 2024
Abstract
Achilles
tendinopathy
(AT)
is
an
injury
caused
by
overuse
of
the
tendon
or
sudden
force
on
tendon,
with
a
considerable
inflammatory
infiltrate.
As
progresses,
inflammation
and
factors
affect
remodeling
extracellular
matrix
(ECM)
tendon.
Gastrodin(Gas),
main
active
ingredient
Astrodia
has
anti‐inflammatory,
antioxidant,
anti‐apoptotic
properties.
The
small
intestinal
submucosa
(SIS)
naturally
decellularized
matrix(dECM)material
high
content
growth
as
well
good
biocompatibility.
However,
reparative
effects
SIS
Gas
their
underlying
mechanisms
remain
unknown.
Here,
it
found
that
hydrogel
loaded
gastrodin
restored
mechanical
strength
facilitated
ECM
remodeling,
ordered
collagen
arrangement
promoting
translocation
protein
synthesis.
It
also
decreases
expression
reduces
infiltration
cells
inhibiting
NF‐κB
signaling
pathway.
believed
through
further
research,
+
may
be
used
in
future
for
treatment
other
disorders.
Phytomedicine,
Journal Year:
2023,
Volume and Issue:
113, P. 154730 - 154730
Published: Feb. 25, 2023
In
our
previous
study,
we
found
that
gentiopicroside
(GPS)
isolated
from
Gentiana
rigescens
Franch
has
a
significant
antiaging
activity
via
regulation
of
mitophagy
and
oxidative
stress.
order
to
increase
the
anti-aging
GPS,
several
compounds
based
on
chemical
structure
GPS
were
synthesized
evaluated
for
bioactivity
with
yeast
replicative
lifespan
assay,
2H-gentiopicroside
(2H-GPS)
as
leading
compound
was
selected
AD
treatment.
To
investigate
whether
2H-GPS
anti-
Alzheimer's
disease
effects,
used
D-galactose
(Dgal)-induced
model
mice
evaluate
effect
mice.
Furthermore,
explored
action
mechanism
this
RT-PCR,
Western
Blot,
ELISA
16S
rRNA
gene
sequence
analysis.
Memory
dysfunction
reduction
in
number
neurons
brain
observed
Dgal
treated
group.
These
symptoms
significantly
relieved
by
administering
donepezil
(Done),
respectively.
only
group,
protein
levels
β-catenin,
REST
phosphorylated
GSK-3β,
involved
Wnt
signaling
pathway
decreased,
whereas
Tau,
P35
PEN-2
increased.
Importantly,
treatment
resulted
restoration
memory
these
proteins.
composition
gut
microbiota
after
administration
through
Moreover,
mice,
which
depleted
antibiotic
cocktail
(ABX),
evaluation
is
2H-GPS.
Significant
changes
between
2H-GPS-treated
ABX
partially
eliminated
AD-restoring
improves
combination
microbiota–gut–brain
axis,
distinct
Done.
Frontiers in Neuroscience,
Journal Year:
2023,
Volume and Issue:
17
Published: April 27, 2023
Being
isolated
from
the
peripheral
system
by
blood–brain
barrier,
brain
has
long
been
considered
a
completely
impervious
tissue.
However,
recent
findings
show
that
gut
microbiome
(GM)
influences
gastrointestinal
and
disorders
such
as
Alzheimer’s
disease
(AD).
Despite
several
hypotheses,
neuroinflammation,
tau
hyperphosphorylation,
amyloid
plaques,
neurofibrillary
tangles,
oxidative
stress,
being
proposed
to
explain
origin
progression
of
AD,
pathogenesis
remains
incompletely
understood.
Epigenetic,
molecular,
pathological
studies
suggest
GM
AD
development
have
endeavored
find
predictive,
sensitive,
non-invasive,
accurate
biomarkers
for
early
diagnosis
monitoring
progression.
Given
growing
interest
in
involvement
current
research
endeavors
identify
prospective
both
preclinical
clinical
diagnoses,
well
targeted
therapy
techniques.
Here,
we
discuss
most
on
changes
microbiome-based
biomarkers,
diagnostic
uses,
approaches.
Furthermore,
addressed
herbal
components,
which
could
provide
new
venue
research.
