Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Oct. 23, 2024
Background
Serum
vitamin
B12
and
α-Klotho
are
important
markers
associated
with
aging.
Limited
studies
have
been
conducted
on
the
relationship
between
α-Klotho.
Objectives
This
study
investigated
circulating
B12.
Methods
A
total
of
4,502
American
adults
levels
from
National
Health
Nutrition
Examination
Survey
(2011–2014)
were
included.
weighted
multiple
linear
regression
model
was
used
to
evaluate
correlation
levels.
To
clarify
potential
non-linearities,
smoothed
curve
fitting
threshold
effects
analysis
employed.
Results
statistically
significant
non-linear
found
after
adjusting
for
confounders.
We
observed
an
inverted
U-shaped
serum
Notably,
below
(1,020
pg/mL)
exhibited
a
positive
(
β
=
0.14,
95%
confidence
interval
(CI):
0.09–0.18,
p
<
0.0001).
Conversely,
above
negative
−0.12,95%
CI:
−0.17−−0.06,
Sensitivity
analyses
performed
consistent
results
obtained.
Conclusion
demonstrated
in
adults.
The
optimal
concentration
found.
Frontiers in Cardiovascular Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: June 4, 2024
Abdominal
Aortic
Aneurysm
(AAA)
is
a
disease
characterized
by
localized
dilation
of
the
abdominal
aorta,
involving
multiple
factors
in
its
occurrence
and
development,
ultimately
leading
to
vessel
rupture
severe
bleeding.
AAA
has
high
mortality
rate,
there
lack
targeted
therapeutic
drugs.
Epigenetic
regulation
plays
crucial
role
AAA,
treatment
epigenetic
field
may
involve
series
related
genes
pathways.
Abnormal
expression
these
be
key
factor
could
potentially
serve
as
promising
targets.
Understanding
significant
importance
revealing
mechanisms
underlying
identifying
new
This
knowledge
can
contribute
offering
patients
better
clinical
options
beyond
surgery.
review
systematically
explores
various
aspects
including
DNA
methylation,
histone
modification,
non-coding
RNA,
RNA
modification.
The
analysis
roles
regulatory
mechanisms,
along
with
identification
relevant
pathways
associated
discussed
comprehensively.
Additionally,
comprehensive
discussion
provided
on
existing
strategies
prospects
for
epigenetics-based
treatments,
insights
future
interventions.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Oct. 23, 2024
Background
Serum
vitamin
B12
and
α-Klotho
are
important
markers
associated
with
aging.
Limited
studies
have
been
conducted
on
the
relationship
between
α-Klotho.
Objectives
This
study
investigated
circulating
B12.
Methods
A
total
of
4,502
American
adults
levels
from
National
Health
Nutrition
Examination
Survey
(2011–2014)
were
included.
weighted
multiple
linear
regression
model
was
used
to
evaluate
correlation
levels.
To
clarify
potential
non-linearities,
smoothed
curve
fitting
threshold
effects
analysis
employed.
Results
statistically
significant
non-linear
found
after
adjusting
for
confounders.
We
observed
an
inverted
U-shaped
serum
Notably,
below
(1,020
pg/mL)
exhibited
a
positive
(
β
=
0.14,
95%
confidence
interval
(CI):
0.09–0.18,
p
<
0.0001).
Conversely,
above
negative
−0.12,95%
CI:
−0.17−−0.06,
Sensitivity
analyses
performed
consistent
results
obtained.
Conclusion
demonstrated
in
adults.
The
optimal
concentration
found.
