Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 15, 2024
Purpose
Potentially
inappropriate
prescribing
(PIP)
is
commonly
encountered
in
older
adults;
yet,
there
limited
information
on
the
occurrence
of
PIP
among
adults
with
hypertension.
This
study
aims
to
determine
and
compare
prevalence
its
association
comorbidities
adult
outpatients
hypertension
across
hospitals
community
health
centers
(CHCs).
Methods
3-year
(2015–2017)
repeated
cross-sectional
used
electronic
medical
records
from
Shenzhen,
China,
involving
62
678
primary
institutions.
was
defined
using
2019
Beers
Criteria.
Older
(≥65
years)
at
least
one
outpatient
prescription
were
included.
Modified
Poisson
regression
analysis
assess
between
chronic
comorbidities,
healthcare
settings,
PIP.
Results
The
old
2015,
2016,
2017
46.32%,
46.98%,
46.58%
hospitals,
a
sample
size
38,411,
46,235,
50,495,
respectively,
29.14%,
26.66%,
29.84%
CHCs,
26,876,
29,434,
34,775
respectively.
top
four
most
popular
CHCs
proton-pump
inhibitors
(PPIs),
diuretics,
benzodiazepines,
non-cyclooxygenase-selective
non-steroidal
anti-inflammatory
drugs
(NSAIDs),
associated
gastrointestinal
disease
(adjusted
ratio
=
1.54,
95%
confidence
interval
[CI]
1.50–1.59)
mental
behavioral
disorders
1.49,
CI
1.46–1.53)
1.99;
1.95–2.03)
musculoskeletal
system
connective
tissue
1.33;
1.31–1.36)
CHCs.
significantly
higher
hospital
settings
than
1.65;
1.63–1.66).
Conclusion
Among
more
prevalent
strongly
Clinical
pharmacy
integration
needs
be
considered
reduce
this
vulnerable
population.
Chinese general practice journal.,
Journal Year:
2024,
Volume and Issue:
1(1), P. 54 - 61
Published: April 1, 2024
:
With
the
aging
of
population,
prevalence
multimorbidity
and
polypharmacy
is
more
common
among
older
adults.
This
increase
may
heighten
risk
potentially
inappropriate
medication
(PIM),
leading
to
adverse
outcomes.
The
study
aimed
systematically
evaluate
associated
factors
PIM
in
community-dwelling
Chinese
adults,
thereby
informing
development
effective
intervention
strategies.
In
June
2022,
an
extensive
literature
review
on
Potentially
Inappropriate
Medications
(PIM)
adults
was
conducted.
CNKI,
CQVIP,
Wanfang
Data,
SinoMed,
PubMed,
EmBase,
Web
Science,
covering
period
from
each
database's
inception
2022.
Two
independent
reviewers
screened
studies,
extracted
data,
assessed
methodological
quality
using
assessment
tool
for
cross-sectional
studies
recommended
by
Agency
Healthcare
Research
Quality.
Meta-analysis
performed
Stata
12.0.
24
were
included
analysis,
comprising
two
high-quality
22
moderate-quality
studies.
meta-analysis
showed
that
34.8%
(95%CI
=
31.3%-38.3%)
China.
Factors
with
age
75
years
or
above
(OR
[95%CI]
1.261
[1.074,
1.481]),
having
five
comorbidities
3.287
[1.405,
7.691]),
taking
medications
1.800
[1.305,
2.481])
10
4.380
[2.612,
7.347]).
considerably
high
Key
include
age,
polypharmacy.
Therefore,
attention
should
be
paid
management
exhibiting
these
characteristics.
BMC Geriatrics,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: June 12, 2024
Abstract
Background
Pharmaceutical
interventions
play
a
key
role
in
the
care
of
older
people
experiencing
polypharmacy.
Despite
rapid
increase
aging
population
Asia,
there
is
lack
evidence
regarding
effectiveness
pharmacist
on
adult’s
healthcare.
This
systematic
review
and
meta-analysis
assessed
effects
Asian
health
environments
hospitalization,
mortality,
quality
life
(QoL)
among
Asia.
Methods
A
comprehensive
search
was
conducted
across
5
databases,
encompassing
studies
published
from
inception
through
June
2023.
Only
involving
for
aged
65
years
or
older,
residing
countries,
were
considered.
Studies
without
involvement
outside
Asia
excluded.
Data
extraction
performed
by
two
reviewers,
one
reviewer
(I.K.)
initial
extraction,
another
(G.R.)
verified
extracted
data.
Forest
plots
generated
using
random
model
to
obtain
risk
ratios
pooled
standardized
mean
differences
(SMDs).
Results
total
170
articles
underwent
thorough
review,
ultimately,
ten
meeting
inclusion
criteria
included
meta-analyses.
These
encompassed
diverse
healthcare
settings
such
as
outpatient,
inpatient,
nursing
homes,
with
sample
sizes
ranging
32
306
people.
Pharmacist
found
significantly
reduce
hospitalization
rates
(
n
=
5,
ratio
0.57,
95%
CI
0.41–0.81)
mortality
4,
0.37–0.88)
The
analysis
revealed
less
significant
improvement
QoL
these
patients
than
those
receiving
usual
6,
SMD
0.36,
P
0.057).
Conclusions
findings
highlight
crucial
pharmacists
within
teams
countries.
have
an
impact
reducing
elderly
people,
underscoring
importance
optimizing
patient
outcomes
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(8), P. 1026 - 1026
Published: Aug. 5, 2024
The
clinical
context
of
drug
interactions
detected
by
automated
analysis
systems
is
particularly
important
in
older
patients
with
multimorbidities.
We
aimed
to
provide
unique,
up-to-date
data
on
the
prevalence
potentially
inappropriate
medications
(PIMs)
and
drug–drug
(DDIs)
Polish
geriatric
population
over
80
years
old
determine
frequency
most
common
PIMs
involved
DDIs.
analyzed
all
non-prescription
prescription
drugs
a
representative
national
group
178
home-dwelling
adults
excessive
polypharmacy
(≥10
drugs).
FORTA
List
was
used
assess
PIMs,
Lexicomp®
Drug
Interactions
database
for
DDIs
were
66.9%
study
group,
whereas
94.4%.
Verification
indications
use
substances
resulted
reduction
total
number
more
than
1.5
times,
as
well
nearly
3-fold
decrease
requiring
therapy
modification
combinations
that
should
be
strictly
avoided.
painkillers,
psychiatry
neurology.
Special
attention
paid
since
they
could
increase
their
character.
interaction
systems,
while
maintaining
appropriate
criticism,
can
both
chances
good
therapeutic
effect
safety
elderly
during
treatment
processes.
The Journal of Clinical Pharmacology,
Journal Year:
2024,
Volume and Issue:
64(12), P. 1505 - 1516
Published: Aug. 14, 2024
This
study
aims
to
meticulously
map
the
bibliometric
landscape
of
drug-drug
interactions
(DDIs)
in
clinical
research.
represents
first
use
analysis
comprehensively
highlight
evolutionary
trends
and
core
themes
this
critical
field
pharmacology.
An
exhaustive
search
was
performed
within
Web
Science
Core
Collection,
aiming
gather
literature
on
DDIs
settings.
A
combination
sophisticated
analytical
tools
including
DIKW,
VOSviewer,
Citespace
utilized
for
an
in-depth
exploration
patterns
trends.
Of
3421
initially
identified
articles,
2622
were
considered
relevant.
The
revealed
a
marked
escalation
publications,
with
peak
observed
2020.
Five
principal
thematic
clusters
emerged:
Safety
Adverse
Reactions,
Drug
Metabolism
Efficacy,
Disease
Treatment,
Research
Methods
Practices,
Special
Populations
Combined
Medication.
Key
insights
included
escalating
significance
drug
metabolism
pharmacokinetics,
heightened
focus
cardiovascular
antiviral
therapeutics,
advancing
frontier
personalized
medicine.
Additionally,
underscored
necessity
strategic
attention
vulnerable
populations
innovative
methodological
approaches.
calls
global
harmonization
research
methods
investigations,
advocating
integration
medicine
paradigms
implementation
cutting-edge
computational
analytics.
It
highlights
imperative
inclusive
collaborative
approaches
adeptly
address
intricate
challenges
contemporary
pharmacotherapy.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 15, 2024
Purpose
Potentially
inappropriate
prescribing
(PIP)
is
commonly
encountered
in
older
adults;
yet,
there
limited
information
on
the
occurrence
of
PIP
among
adults
with
hypertension.
This
study
aims
to
determine
and
compare
prevalence
its
association
comorbidities
adult
outpatients
hypertension
across
hospitals
community
health
centers
(CHCs).
Methods
3-year
(2015–2017)
repeated
cross-sectional
used
electronic
medical
records
from
Shenzhen,
China,
involving
62
678
primary
institutions.
was
defined
using
2019
Beers
Criteria.
Older
(≥65
years)
at
least
one
outpatient
prescription
were
included.
Modified
Poisson
regression
analysis
assess
between
chronic
comorbidities,
healthcare
settings,
PIP.
Results
The
old
2015,
2016,
2017
46.32%,
46.98%,
46.58%
hospitals,
a
sample
size
38,411,
46,235,
50,495,
respectively,
29.14%,
26.66%,
29.84%
CHCs,
26,876,
29,434,
34,775
respectively.
top
four
most
popular
CHCs
proton-pump
inhibitors
(PPIs),
diuretics,
benzodiazepines,
non-cyclooxygenase-selective
non-steroidal
anti-inflammatory
drugs
(NSAIDs),
associated
gastrointestinal
disease
(adjusted
ratio
=
1.54,
95%
confidence
interval
[CI]
1.50–1.59)
mental
behavioral
disorders
1.49,
CI
1.46–1.53)
1.99;
1.95–2.03)
musculoskeletal
system
connective
tissue
1.33;
1.31–1.36)
CHCs.
significantly
higher
hospital
settings
than
1.65;
1.63–1.66).
Conclusion
Among
more
prevalent
strongly
Clinical
pharmacy
integration
needs
be
considered
reduce
this
vulnerable
population.
