Prevalence and trends of polypharmacy in U.S. adults, 1999–2018

Global Health Research and Policy, Journal Year: 2023, Volume and Issue: 8(1)

Published: July 12, 2023

Abstract Background Polypharmacy is one of the most important health issues for its potential impacts on disease burden and healthcare costs. The aim this study was to update a comprehensive picture prevalence trends in polypharmacy over 20 years U.S. adults. Methods Participants included 55,081 adults aged ≥ from National Health Nutrition Examination Survey, January 1, 1999, through December 31, 2018. simultaneously use 5 drugs individual defined as polypharmacy. were evaluated among within different demo-socioeconomic status pre-existing diseases. Results From 1999–2000 2017–2018, overall percentages with remained rise, increasing 8.2% (7.2–9.2%) 17.1% (15.7–18.5%) (average annual percentage change [AAPC] = 2.9%, P .001). considerably higher elderly (from 23.5% 44.1%), heart 40.6% 61.7%), diabetes 36.3% 57.7%). Also, we observed greater increase rate men (AAPC 4.1%, < .001), Mexican American 6.3%, non-Hispanic Black 4.4%, Conclusions continually especially older, patients disease, or diabetes. high urges providers policymakers manage specific population groups.

Language: Английский

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Cumulative Update of a Systematic Overview Evaluating Interventions Addressing Polypharmacy

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(1), P. e2350963 - e2350963

Published: Jan. 10, 2024

Importance Polypharmacy is associated with mortality, falls, hospitalizations, and functional cognitive decline. The study of polypharmacy-related interventions has increased substantially, prompting the need for an updated, more focused systematic overview. Objective To systematically evaluate summarize evidence across multiple reviews (SRs) examining addressing polypharmacy. Evidence Review A search was conducted MEDLINE, Cochrane Database Systematic Reviews, Abstracts Reviews Effects articles published from January 2017-October 2022, as well those identified in a previous overview (January 2004-February 2017). were included regardless design, setting, or outcome. summarized by 4 categories: (1) medication-related process outcomes (eg, potentially inappropriate medication [PIM] potential prescribing omission reductions), (2) clinical outcomes, (3) health care use economic (4) acceptability intervention. Findings Fourteen SRs (3 overview), 7 which meta-analyses, representing 179 unique studies. Nine examined (low to very low quality). using pooled analyses found significant reductions number PIMs, omissions, total medications, improvements appropriateness. Twelve (very moderate Five mortality; all mortality meta-analyses null, but studies longer follow-up periods greater mortality. falls incidence; results predominantly null save meta-analysis PIMs discontinued. Of 8 quality life, most (7) effects. Ten hospitalizations readmissions quality) emergency department visits One SR among higher-intensity face-to-face patient components. Another effect. without readmissions, had results. Two visits. quality), finding wide variation adoption interventions. Conclusions Relevance This updated noted little association between reduced important outcomes. More needed regarding are useful populations would benefit most.

Language: Английский

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Recent development of machine learning models for the prediction of drug-drug interactions

Korean Journal of Chemical Engineering, Journal Year: 2023, Volume and Issue: 40(2), P. 276 - 285

Published: Feb. 1, 2023

Language: Английский

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Reducing polypharmacy through deprescribing in the emergency department

Medicine, Journal Year: 2025, Volume and Issue: 104(10), P. e41590 - e41590

Published: March 7, 2025

Polypharmacy, the use of multiple medications, is a prevalent issue globally that contributes to increased healthcare costs and places additional burdens on patients' organs. This study aims deprescribe prevent polypharmacy in emergency department. We conducted retrospective review randomly selected medical records from Internal Medicine Department Taipei MacKay Emergency Department, spanning August 1, 2023, October 31, 2023. For cases identified as involving polypharmacy, pharmacists provided medication education using Team Resource Management Polypharmacy Interview Guide, while social workers contacted patients via phone recommend follow-up visits for deprescribing. Patients experiencing were significantly older than those appropriate regimens (79.8 vs 67.3 years, P = .002). After deprescribing interventions, average number medications was 5.9 higher receiving prescriptions (9.2 3.3, .001). The most common conditions associated with diabetes mellitus, hypertension, arrhythmia. poses significant management challenge, affected taking an 6.9 more treatment regimens. resource module our team successfully reduced incidence by 8.4%

Language: Английский

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Polypharmacy and Elevated Risk of Severe Adverse Events in Older Adults Based on the Korea Institute of Drug Safety and Risk Management-Korea Adverse Event Reporting System Database

Journal of Korean Medical Science, Journal Year: 2024, Volume and Issue: 39(28)

Published: Jan. 1, 2024

Older adults are at a higher risk of severe adverse drug events (ADEs) because multimorbidity, polypharmacy, and lower physiological function. This study aimed to determine whether defined as the use ≥ 5 active ingredients, was associated with ADEs in this population. We used ADE reports from Korea Institute Drug Safety Risk Management-Korea Adverse Event Reporting System Database, national spontaneous report system, 2012 2021 examine compare strength association between polypharmacy older (≥ 65 years) younger (20-64 using disproportionality analysis. found significant cardiac renal/urinary Medical Dictionary for Regulatory Activities Organ Classes (MedDRA SOC) adults. Regarding individual-level included these MedDRA SOCs, acute arrest renal failure were more significantly compared The addition new drugs regimens warrants close monitoring symptoms.

Language: Английский

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Trends in commonly used and potentially inappropriate medications in older Korean patients with polypharmacy

BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: June 21, 2024

Polypharmacy is a global public health concern. This study aimed to determine the prevalence of polypharmacy and trends in use commonly used potentially inappropriate medications among older Korean patients.

Language: Английский

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Prevalence and Predictors of Excessive Polypharmacy in Geriatric Inpatients: A Retrospective Cross-Sectional Study in Indonesia

Journal of Primary Care & Community Health, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 1, 2023

To investigate the prevalence and predictors of excessive polypharmacy in geriatric inpatients Indonesia.This retrospective cross-sectional study included 1533 over age 60 years at Universitas Airlangga Hospital, Indonesia. Effects a patient's baseline characteristics on were evaluated using logistic regression analysis.Excessive was observed 133 (8.67%) patients. Ulcer (OR 8.151,95% CI 2.234-29.747, P = .001), cancer 5.551, 95% 1.602-19.237, .007), renal diseases 3.710, 1.965-7.006, < .001) 3 strongest polypharmacy. An association between hospital stay more than days identified 2.382, 1.109-5.115, .026).One 12 elderly Indonesians found to practice Several chronic conditions increased length factors associated with

Language: Английский

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Polypharmacy and associated factors in South Korean elderly patients with dementia: An analysis using National Health Insurance claims data

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(4), P. e0302300 - e0302300

Published: April 25, 2024

Dementia is accompanied by several symptoms, including cognitive function decline, as well behavioral and psychological symptoms. Elderly patients with dementia often experience polypharmacy, the concurrent use of multiple medications, due to chronic comorbidities. However, research on polypharmacy in limited. This study aimed characterize associated factors among elderly South Korea, compare characteristics without patients.

Language: Английский

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The association between continuous polypharmacy and hospitalization, emergency department visits, and death in older adults: a nationwide large cohort study

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 31, 2024

This study aimed to investigate the association between continuous polypharmacy and hospitalization, emergency department (ED) visits, death.

Language: Английский

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Age-Related Changes in Oral Health, Salivary Parameters, Halitosis, and Systemic Diseases and Medication Usage

Published: Aug. 28, 2024

Background The increasing number of elderly individuals in South Korea, now entering a super-aging era, underscores the growing importance understanding their specific oral health needs. This study investigated changes conditions, salivary parameters, halitosis, systemic diseases, and medication usage with aging. Methods was retrospectively conducted using medical records patients who presented complaints xerostomia or halitosis between August 2020 May 2023. A total 274 (66 males, 208 females, mean age 59.39 ± 16.10 years) were included this study. Results Aging found to be significantly associated presence sticky saliva, poor hygiene, tongue coating, (all p &lt; 0.05). Correlation analyses further revealed significant associations aging several including hypertension (r = 0.495, 0.001), diabetes mellitus 0.255, amlodipine 0.249, osteoporosis 0.195, cardiovascular disease 0.150, 0.013), coating 0.205, 0.001). Conversely, none parameters demonstrated relationship Furthermore, did not exhibit differences across groups &gt; 0.05), exception methyl mercaptan levels, which notably higher among 20s (p 0.049). Conclusions findings can help clinicians develop targeted strategies address challenges patients.

Language: Английский

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