Reviews in the Neurosciences,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 7, 2025
Abstract
Alzheimer’s
disease
(AD),
a
progressive
neurodegenerative
disorder,
is
marked
by
cognitive
decline,
neuroinflammation,
and
neuronal
loss.
MicroRNAs
(miRNAs)
have
emerged
as
critical
regulators
of
gene
expression,
influencing
key
pathways
involved
in
neuroinflammation
neurodegeneration
AD.
This
review
delves
into
the
multifaceted
role
exercise
modulating
miRNA
expression
its
interplay
with
gut
microbiome,
proposing
comprehensive
framework
for
neuroprotection
By
synthesizing
current
research,
we
elucidate
how
exercise-induced
changes
profiles
can
mitigate
inflammatory
responses,
promote
neurogenesis,
reduce
amyloid-beta
tau
pathologies.
Additionally,
explore
gut–brain
axis,
highlighting
exercise-driven
alterations
microbiota
composition
further
influence
thereby
enhancing
function
reducing
neuroinflammatory
markers.
holistic
approach
underscores
potential
targeting
exercise-regulated
miRNAs
microbiome
interactions
novel,
noninvasive
therapeutic
strategy
to
decelerate
AD
progression
improve
quality
life
patients.
aims
patient
outcomes,
offering
promising
avenue
effectiveness
management.
Cells,
Journal Year:
2024,
Volume and Issue:
13(23), P. 1987 - 1987
Published: Dec. 1, 2024
The
gut
microbiota
significantly
impacts
human
health,
influencing
metabolism,
immunological
responses,
and
disease
prevention.
Dysbiosis,
or
microbial
imbalance,
is
linked
to
various
diseases,
including
cancer.
It
crucial
preserve
a
healthy
microbiome
since
pathogenic
bacteria,
such
as
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(40)
Published: April 25, 2024
Abstract
The
oral
delivery
of
most
atypical
antipsychotics
is
severely
challenged
by
their
low
bioavailability
and
significant
food
effects
that
necessitate
patient
compliance.
Lipid
formulations
are
an
attractive
system
for
overcoming
the
dosing
challenges
antipsychotics,
but
negative
impact
on
gut
microbiota
can
interfere
with
pharmacodynamic
response
through
disruption
gut‐brain
axis.
Here,
novel
microbiota‐targeting
microcapsules
engineered
to
provide
a
multifunctional
approach
improving
both
pharmacokinetic
properties
antipsychotic,
lurasidone.
comprised
lipid
core
facilitates
solubilization
absorption
lipophilic
drug
outer
carbohydrate
polymer
(inulin)
shell
positively
modulates
facilitating
microbial
fermentation.
Fed‐fasted
variability
in
lurasidone
mitigated
microencapsulation
inulin‐lipid
(ILM),
while
enrichment
coupled
enhanced
serotonin
levels
small
intestine,
faeces,
plasma.
realization
ILM
confirms
pharmacokinetics
efficacy
mental
health
therapies,
such
as
be
optimized
strategic
encapsulation
within
functional
target
effective
modulation
Expert Opinion on Drug Delivery,
Journal Year:
2023,
Volume and Issue:
20(10), P. 1315 - 1331
Published: July 5, 2023
Introduction
The
trillions
of
microorganisms
that
comprise
the
gut
microbiome
form
dynamic
bidirectional
interactions
with
orally
administered
drugs
and
host
health.
These
relationships
can
alter
all
aspects
drug
pharmacokinetics
pharmacodynamics
(PK/PD);
thus,
there
is
a
desire
to
control
these
maximize
therapeutic
efficacy.
Attempts
modulate
drug-gut
have
spurred
advancements
within
field
'pharmacomicrobiomics'
are
poised
become
next
frontier
oral
delivery.Areas
covered
This
review
details
exist
between
microbiome,
clinically
relevant
case
examples
outlining
clear
motive
for
controlling
pharmacomicrobiomic
interactions.
Specific
focus
attributed
novel
advanced
strategies
demonstrated
success
in
mediating
interactions.Expert
opinion
Co-administration
gut-active
supplements
(e.g.
pro-
pre-biotics),
innovative
delivery
vehicles,
strategic
polypharmacy
serve
as
most
promising
viable
approaches
Targeting
through
presents
new
opportunities
improving
efficacy
by
precisely
PK/PD,
while
mitigating
metabolic
disturbances
caused
drug-induced
dysbiosis.
However,
successfully
translating
preclinical
potential
into
clinical
outcomes
relies
on
overcoming
key
challenges
related
interindividual
variability
composition
study
design
parameters.
Metabolites,
Journal Year:
2024,
Volume and Issue:
14(12), P. 683 - 683
Published: Dec. 5, 2024
Background:
The
human
digestive
system
contains
approximately
100
trillion
bacteria.
gut
microbiota
is
an
emerging
field
of
research
that
associated
with
specific
biological
processes
in
many
diseases,
including
cardiovascular
disease,
obesity,
diabetes,
brain
rheumatoid
arthritis,
and
cancer.
Emerging
evidence
indicates
the
affects
response
to
anticancer
therapies
by
modulating
host
immune
system.
Recent
studies
have
explained
a
high
correlation
between
breast
cancer:
dysbiosis
cancer
may
regulate
systemic
inflammatory
response,
hormone
metabolism,
tumor
microenvironment.
Some
bacteria
are
related
estrogen
which
increase
or
decrease
risk
changing
number
hormones.
Further,
has
been
seen
modulate
respect
its
ability
protect
against
treat
cancers,
focus
on
receptor-positive
Probiotics
other
claiming
control
microbiome
bacterial
means
might
be
useful
prevention,
even
treatment,
Conclusions:
present
review
underlines
various
aspects
clinical
application,
warranting
individualized
microbiome-modulated
therapeutic
approaches
treatment.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(12), P. 2776 - 2776
Published: Dec. 6, 2024
The
gut
microbiota
plays
a
crucial
role
in
modulating
anticancer
immunity,
significantly
impacting
the
effectiveness
of
various
cancer
therapies,
including
immunotherapy,
chemotherapy,
and
radiotherapy.
Its
impact
on
development
is
complex;
certain
bacteria,
like
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Jan. 25, 2023
Second-generation
antipsychotics
(SGAs)
are
the
mainstay
of
treatment
for
schizophrenia
and
other
neuropsychiatric
diseases
but
cause
a
high
risk
disruption
to
lipid
metabolism,
which
is
an
intractable
therapeutic
challenge
worldwide.
Although
exact
mechanisms
underlying
this
disturbance
complex,
increasing
body
evidence
has
suggested
involvement
gut
microbiota
in
SGA-induced
dysregulation
since
SGA
may
alter
abundance
composition
intestinal
microflora.
The
subsequent
effects
involve
generation
different
categories
signaling
molecules
by
microbes
such
as
endogenous
cannabinoids,
cholesterol,
short-chain
fatty
acids
(SCFAs),
bile
(BAs),
hormones
that
regulate
metabolism.
On
one
hand,
these
can
directly
activate
vagus
nerve
or
be
transported
into
brain
influence
appetite
via
gut–brain
axis.
also
related
metabolism
peripheral
pathways.
Interestingly,
strategies
targeting
metabolites
seem
have
promising
efficacy
disturbances.
Thus,
review
provides
comprehensive
understanding
how
SGAs
induce
disturbances
altering
microbiota.
Microbiology Spectrum,
Journal Year:
2023,
Volume and Issue:
11(4)
Published: June 1, 2023
Olanzapine
is
one
of
the
most
effective
second-generation
antipsychotics
for
stabilizing
schizophrenia
spectrum
disorders.
However,
olanzapine
has
multiple
drug-induced
metabolic
side
effects,
including
weight
gain.