Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: June 19, 2024
Honokiol,
a
naturally
occurring
compound
from
Magnolia
obovata
Thunb
.,
has
many
biological
activities,
but
its
anti-α-glucosidase
activity
is
still
unclear.
Therefore,
we
determined
inhibitory
effects
against
α-glucosidase.
Activity
assays
showed
that
honokiol
was
reversible
mixed-type
inhibitor
of
α-glucosidase,
and
IC
50
value
317.11
±
12.86
μM.
Fluorescence
results
indicated
the
binding
to
α-glucosidase
caused
reduction
in
activity.
3D
fluorescence
CD
spectra
conformational
change
Docking
simulated
detailed
interactions
between
including
hydrogen
hydrophobic
bonds.
All
findings
could
be
used
as
natural
develop
agents.
Toxics,
Journal Year:
2023,
Volume and Issue:
11(2), P. 114 - 114
Published: Jan. 24, 2023
Curcumol,
a
natural
product
isolated
from
the
traditional
Chinese
medicine
Rhizoma
curcumae,
possesses
various
potential
therapeutic
values
in
many
diseases.
However,
evidence
of
its
toxicological
profile
is
currently
lacking.
In
this
study,
repeated
toxicity
study
curcumol
was
conducted
for
first
time.
SD
rats
were
exposed
to
doses
250,
500,
1000
mg/kg
selected
dose
formulation
28
days
through
oral
administration.
The
toxic
effects
on
blood
system
observed
and
further
validated
vivo
vitro.
Moreover,
other
hematology
biochemistry
parameters
as
well
weight
organs
altered,
but
no
related
histopathological
signs
observed,
indicating
these
changes
not
regarded
toxicologically
relevant.
Our
current
findings
provide
complete
understanding
safety
curcumol,
which
may
contribute
investigational
new
drug
application.
Chemistry & Biodiversity,
Journal Year:
2024,
Volume and Issue:
21(5)
Published: March 11, 2024
Abstract
Curcumae
Radix
(CuR)
is
a
traditional
Chinese
medicine
that
has
been
used
in
China
for
more
than
1,000
years.
It
the
efficacy
of
activating
blood
and
relieving
pain,
promoting
qi
depression,
clearing
heart
cooling
blood,
gallbladder
removing
jaundice.
Based
on
this,
many
domestic
foreign
scholars
have
conducted
systematic
studies
its
chemical
composition,
pharmacological
effects,
toxicity
quality
control.
Currently,
250
compounds,
mainly
including
terpenoids
curcuminoids,
isolated
identified
from
CuR,
which
activities,
antitumor,
anti‐inflammatory
analgesic,
antidepressant,
hepatoprotective,
hemostatic,
hematopoietic,
treatment
diabetes
mellitus.
In
modern
clinical
practice,
CuR
widely
tumors,
breast
hyperplasia,
hepatitis,
stroke.
However,
generation
application
Caryophylli
Flos,
determination
concoction
process
artifacts,
specific
Quality
Marker,
establishment
control
system
are
problems
need
to
be
solved
urgently
at
present.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: June 19, 2024
Honokiol,
a
naturally
occurring
compound
from
Magnolia
obovata
Thunb
.,
has
many
biological
activities,
but
its
anti-α-glucosidase
activity
is
still
unclear.
Therefore,
we
determined
inhibitory
effects
against
α-glucosidase.
Activity
assays
showed
that
honokiol
was
reversible
mixed-type
inhibitor
of
α-glucosidase,
and
IC
50
value
317.11
±
12.86
μM.
Fluorescence
results
indicated
the
binding
to
α-glucosidase
caused
reduction
in
activity.
3D
fluorescence
CD
spectra
conformational
change
Docking
simulated
detailed
interactions
between
including
hydrogen
hydrophobic
bonds.
All
findings
could
be
used
as
natural
develop
agents.
