Cell Death and Disease,
Journal Year:
2022,
Volume and Issue:
13(9)
Published: Sept. 26, 2022
Abstract
Oxidative
stress
is
a
vital
contributor
to
the
development
and
progression
of
diabetes-accelerated
atherosclerosis.
Nuclear
factor
erythroid
2-related
2
(Nrf2)
well-known
molecule
that
participates
in
cellular
defense
against
oxidative
stress.
Utilizing
luciferase
reporter
assay
from
379
natural
products,
we
reported
here
Ginsenoside
Rb1
played
dual
role
inhibiting
Kelch-like
ECH-associated
protein
1
(Keap1)
p47
phox
activities.
In
endothelial
cells
(ECs),
pretreatment
enhanced
cell
viability,
reduced
stress,
inflammation,
endothelial-mesenchymal
transition
(EndMT),
apoptosis,
as
well
ameliorated
mitochondrial
quality
following
oxidized
low-density
lipoprotein
(ox-LDL)
plus
high
glucose
(HG)
challenge.
directly
bound
Keap1
promoted
its
ubiquitination
proteasomal
degradation
dependent
on
lysine
residues
(K108,
K323,
K551)
by
recruiting
E3
ligase
synovial
apoptosis
inhibitor
(SYVN1),
leading
Nrf2
dissociation
Keap1,
nuclear
translocation,
Nrf2/PGC-1α
complex
formation.
We
further
identified
could
bind
reduce
phosphorylation
membrane
thereby
disrupting
assembly
NOX2
complex.
Importantly,
Rb1-mediated
preservation
cytoplasmic
stabilized
contributed
activation.
Additionally,
revealed
aortic
atherosclerotic
plaque
formation
along
with
reductions
inflammatory
response
streptozotocin
(STZ)-induced
ApoE
−/−
mice,
but
not
mice
deficiency
PGC-1α.
Collectively,
demonstrated
Rb1,
which
targeted
ECs,
may
be
an
attractive
candidate
for
treatment
atherosclerosis
diabetes.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 24, 2024
Ginseng
is
frequently
used
in
traditional
Chinese
medicine
to
treat
neurological
disorders.
The
primary
active
component
of
ginseng
ginsenoside,
which
has
been
classified
into
more
than
110
types
based
on
their
chemical
structures.
Ginsenoside
Rb1
(GsRb1)—a
protopanaxadiol
saponin
and
a
typical
component—exhibits
anti-inflammatory,
anti-oxidant,
anti-apoptotic,
anti-autophagy
properties
the
nervous
system.
Neurological
disorders
remain
leading
cause
death
disability
globally.
GsRb1
effectively
treats
To
contribute
novel
insights
understanding
treatment
disorders,
we
present
comprehensive
review
pharmacokinetics,
actions,
mechanisms,
research
development
IUBMB Life,
Journal Year:
2024,
Volume and Issue:
76(11), P. 862 - 882
Published: June 1, 2024
Abstract
Ginsenosides
are
the
primary
component
discernible
from
ginseng,
including
Rb1,
Rb2,
Rd,
Rg1,
Rg2,
and
compound
K,
so
forth.
They
have
been
shown
to
multiple
pharmacological
activities.
In
recent
years,
more
studies
devoted
neuroprotection
of
various
ginsenosides
against
neurological
diseases
their
potential
mechanisms.
This
paper
comprehensively
summarizes
reviews
neuroprotective
effects
on
diseases,
especially
acute
chronic
neurodegenerative
mechanisms,
as
well
therapeutic
applications
promote
in
disease
prevention,
treatment,
prognosis.
Briefly,
exert
effective
conditions,
stroke,
Alzheimer's
disease,
Parkinson's
brain/spinal
cord
injuries
through
a
variety
molecular
anti‐inflammatory,
antioxidant,
anti‐apoptotic.
Among
them,
some
signaling
pathways
play
important
roles
related
processes,
such
PI3K/Akt,
TLR4/NF‐κB,
ROS/TXNIP/NLRP3,
HO‐1/Nrf2,
Wnt/β‐catenin,
Ca
2+
pathway.
conclusion,
present
study
research
progress
last
decade,
with
aim
furnishing
essential
theoretical
underpinning
references
for
further
exploration
medicinal
values
Chinese
herbal
medicines
small
molecule
compounds,
ginseng
panax
ginseng.
Because
there
is
less
evidence
existing
clinical
studies,
future
should
be
focused
trials
order
truly
reflect
value
benefit
patients.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: March 22, 2024
Abstract
After
intracerebral
hemorrhage
(ICH)
occurs,
the
overproduction
of
reactive
oxygen
species
(ROS)
and
iron
ion
overload
are
leading
causes
secondary
damage.
Removing
excess
ions
ROS
in
meningeal
system
can
effectively
alleviate
damage
after
ICH.
This
study
synthesized
ginsenoside
Rb1
carbon
quantum
dots
(RBCQDs)
using
ethylenediamine
via
a
hydrothermal
method.
RBCQDs
exhibit
potent
capabilities
scavenging
ABTS
+
free
radicals
solution.
intrathecal
injection,
distribution
is
predominantly
localized
subarachnoid
space.
eliminate
chelate
within
system.
Treatment
with
significantly
improves
blood
flow
system,
protecting
dying
neurons,
improving
neurological
function,
providing
new
therapeutic
approach
for
clinical
treatment
Molecules,
Journal Year:
2023,
Volume and Issue:
28(5), P. 2416 - 2416
Published: March 6, 2023
Panax
notoginseng
(Burk)
F.
H.
Chen
is
a
traditional
Chinese
medicinal
and
edible
plant.
However,
flower
(PNF)
rarely
used.
Therefore,
the
purpose
of
this
study
was
to
explore
main
saponins
anti-inflammatory
bioactivity
PNF
(PNFS).
We
explored
regulation
cyclooxygenase
2
(COX-2),
key
mediator
inflammatory
pathways,
in
human
keratinocyte
cells
treated
with
PNFS.
A
cell
model
UVB-irradiation-induced
inflammation
established
determine
influence
PNFS
on
factors
their
relationship
LL-37
expression.
An
enzyme-linked
immunosorbent
assay
Western
blotting
analysis
were
used
detect
production
LL37.
Finally,
liquid
chromatography-tandem
mass
spectrometry
employed
quantify
active
components
(ginsenosides
Rb1,
Rb2,
Rb3,
Rc,
Rd,
Re,
Rg1,
notoginsenoside
R1)
PNF.
The
results
show
that
substantially
inhibited
COX-2
activity
downregulated
factors,
indicating
they
can
be
reduce
skin
inflammation.
also
increased
expression
LL-37.
contents
ginsenosides
Rd
much
higher
than
those
R1.
This
paper
provides
data
support
application
cosmetics.
