Exploring beyond Common Cell Death Pathways in Oral Cancer: A Systematic Review

Biology, Journal Year: 2024, Volume and Issue: 13(2), P. 103 - 103

Published: Feb. 6, 2024

Oral squamous cell carcinoma (OSCC) is the most common and lethal type of head neck cancer in world. Variable response acquisition resistance to traditional therapies show that it essential develop novel strategies can provide better outcomes for patient. Understanding cellular molecular mechanisms death control has increased rapidly recent years. Activation pathways, such as emerging forms non-apoptotic programmed death, including ferroptosis, pyroptosis, necroptosis, NETosis, parthanatos, mitoptosis paraptosis, may represent clinically relevant therapeutic opportunities. This systematic review summarizes recently described OSCC, highlighting their potential informing diagnosis, prognosis treatment. Original studies explored any selected deaths OSCC were included. Electronic search, study selection, data collection risk bias assessment tools realized. The literature search was carried out four databases, extracted from 79 articles categorized grouped by death. Ferroptosis, necroptosis represented main studies, with links immunity inflammatory responses, progression OSCC. Harnessing these pathways be useful patient-specific individualized therapy. We perspectives on how different types integrated decision prognosis, treatment

Language: Английский

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Ferroptosis as an emerging target in sickle cell disease

Current Research in Toxicology, Journal Year: 2024, Volume and Issue: 7, P. 100181 - 100181

Published: Jan. 1, 2024

Sickle cell disease (SCD) is an inherited hemoglobin disorder marked by red blood sickling, resulting in severe anemia, painful episodes, extensive organ damage, and shortened life expectancy. In SCD, increased iron levels can trigger ferroptosis, a specific type of death characterized reactive oxygen species (ROS) lipid peroxide accumulation, leading to damage impairments. The intricate interplay between iron, inflammation, oxidative stress SCD underscores the necessity thoroughly understanding these processes for development innovative therapeutic strategies. This review highlights importance balancing complex interactions among various factors exploitation knowledge developing novel therapeutics this devastating disease.

Language: Английский

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25-Hydroxycholesterol induces oxidative stress, leading to apoptosis and ferroptosis in extravillous trophoblasts

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 403, P. 111214 - 111214

Published: Aug. 27, 2024

Language: Английский

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Pharmacological modulation of ferroptosis as a therapeutic target for liver fibrosis

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 10, 2023

Liver fibrosis, which is characterized by the excessive deposition of extracellular matrix (ECM) materials (primarily fibrillar collagen-I), an abnormal repair reaction and pathological outcome chronic liver diseases caused alcohol abuse, non-alcoholic fatty disease, hepatitis B C virus infections. fibrosis often progresses to cirrhosis hepatocellular carcinoma. Ferroptosis, lipid peroxidation, a form iron-dependent non-apoptotic cell death, recent studies have reported that ferroptosis contribute development fibrosis. Moreover, several agents demonstrated therapeutic effects in experimental models inducing hepatic stellate (HSCs) ferroptosis. This review delineates specific mechanism contributes Specifically, we focused on different types can induce HSCs summarize their pharmacological effectiveness for treatment. We suggest may be potential useful target novel therapies preventing treating

Language: Английский

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NAT10 promotes renal ischemia-reperfusion injury via activating NCOA4-mediated ferroptosis

Heliyon, Journal Year: 2024, Volume and Issue: 10(2), P. e24573 - e24573

Published: Jan. 1, 2024

Ischemia-reperfusion injury (IRI) is a significant contributor to acute kidney (AKI) and associated with substantial morbidity mortality rates. In this study, we aimed investigate the role of NAT10 its ac4C RNA modification in IRI-induced renal injury. Our findings revealed that both expression level kidneys were elevated IRI group compared sham group. Functionally, observed inhibition activity Remodelin or specific knockout led attenuation Furthermore, vitro experiments demonstrated markedly suppressed global modification, providing protection against hypoxia/reoxygenation-induced tubular epithelial cell ferroptosis. Mechanistically, our study uncovered promoted NCOA4 mRNA, thereby enhancing stability contributing ferroptosis cells (TECs). These underscore potential as promising therapeutic targets for treatment AKI. Overall, sheds light on critical involvement pathogenesis injury, offering valuable insights development novel AKI strategies.

Language: Английский

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Kaempferol stimulation of autophagy regulates the ferroptosis under the oxidative stress as mediated with AMP-activated protein kinase

Free Radical Biology and Medicine, Journal Year: 2023, Volume and Issue: 208, P. 630 - 642

Published: Sept. 12, 2023

Language: Английский

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Mechanisms of Ferritinophagy and Ferroptosis in Diseases

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 61(3), P. 1605 - 1626

Published: Sept. 22, 2023

Language: Английский

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Iron regulatory proteins: players or pawns in ferroptosis and cancer?

Frontiers in Molecular Biosciences, Journal Year: 2023, Volume and Issue: 10

Published: June 29, 2023

Cells require iron for essential functions like energy production and signaling. However, can also engage in free radical formation promote cell proliferation thereby contributing to both tumor initiation growth. Thus, the amount of within body individual cells is tightly regulated. At cellular level, homeostasis maintained post-transcriptionally by regulatory proteins (IRPs). Ferroptosis an iron-dependent form programmed death with vast chemotherapeutic potential, yet while IRP-dependent targets have established roles ferroptosis, our understanding contributions IRPs themselves still its infancy. In this review, we present growing circumstantial evidence suggesting that play critical adaptive response ferroptosis ferroptotic describe how knowledge be leveraged target neoplastic dysregulation more effectively.

Language: Английский

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Expanding the Concept of Iron Deficiency Using a Mitochondrial Metabolic Approach: Explaining and Preventing Sudden Death

Pediatric Blood & Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Language: Английский

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Bee Pollen Potential to Modulate Ferroptosis: Phytochemical Insights for Age-Related Diseases

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 265 - 265

Published: Feb. 25, 2025

Bee pollen (BP) is one of the richest known natural resources micronutrients and bioactive phytochemicals. Some captivating bioactivities BP compounds, although being largely investigated for latter as individual molecules, remain very scarcely or completely uninvestigated in bee a whole product. Among most intriguing these bioactivities, we identified ferroptosis major one. Ferroptosis, recently discovered form cell death (connecting oxidative stress inflammation), complex pathophysiological process crucial perplexing events current challenging human diseases such cancer, neurodegeneration, general aging diseases. Many compounds were found to intricately modulate depending on cellular context by inducing this mechanism malignant cells preventing it non-malignant cells. Since research both fields, i.e., ferroptosis, still recent, deemed necessary undertake review figure out extent potential modulating mechanisms. Our proved that wide range (polyphenols, phenolamides, carotenoids, vitamins, minerals, others) substantially diverse Accordingly, phytochemicals nutrients showed interesting preclinical studies lead ferroptosis-mediated outcomes important processes, including many aging-related disorders. One paramount challenges be resolved determine how different act biological contexts, either through synergistic antagonistic behaviors. We hope our work constitutes valuable incentive future investigations promising relevant avenue.

Language: Английский

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