Metabolic
syndrome
(MetS)
affects
20–25%
of
adults
and
as
many
19.5–20%
adolescents.
MetS
negatively
impacts
multiple
physiological
processes.
Natural
compounds
have
an
exceptionally
bright
aspect
with
a
promising
alternative
to
synthetic
medications.
Plant
polysaccharides
(PPSs),
which
are
made
up
at
least
ten
monosaccharides,
exhibit
excellent
safety
range
pharmacological
actions,
such
anti-apoptotic,
antihyperglycemic,
antihyperlipidemic,
antioxidant,
anti-fibrotic
benefits.
However,
the
benefits
numerous
PPS
for
metabolic
disorders,
including
gastroesophageal
reflux
disease,
cardiovascular
chronic
renal
pulmonary
diseases,
often
brought
on
by
malfunction
in
metabolism
lipids,
glucose,
peptides.
Therefore,
quantity
articles
focusing
antioxidative
PPSs
steadily
increased
over
past
decade.
This
chapter
outlines
attributes
cellular
mechanisms
several
disorders.
In
addition,
interaction
various
genes
proteins
involved
molecular
signaling
pathways
is
briefly
elucidated.
Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(30), P. 11627 - 11641
Published: July 20, 2023
Solid
evidence
has
emerged
supporting
the
role
of
nonextractable
polyphenols
(NEPs)
and
dietary
fibers
(DFs)
as
gut
microbiota
modulators.
This
study
aims
to
elucidate
microbiota-dependent
release
turmeric
NEPs
examine
possible
anti-inflammatory
mechanism
in
dextran
sulfate
sodium-induced
ulcerative
colitis
(UC)
model.
1.5%
DSS
drinking
water-induced
C57BL/6J
mice
were
fed
a
standard
rodent
chow
supplemented
with
or
without
8%
extractable
(EPs),
NEPs,
DFs
for
37
days.
The
bound
curcumin,
demethoxycurcumin,
bisdemethoxycurcumin
released
up
181.5
±
10.6,
65.2
6.0,
69.5
7.6
μg/mL
by
vitro
microbiota-simulated
fermentation
into
colon
NEP-supplemented
5.7-,
11.0-,
7.8-fold
higher
than
pseudo
germ-free
mice,
respectively
(p
<
0.05).
also
enhanced
colonic
production
short-chain
fatty
acids
vivo
Interestingly,
NEP
feeding
significantly
improved
DSS-caused
disorder,
epithelial
barrier
damage,
inflammation
UC
better
EPs
Meanwhile,
failed
ameliorate
symptoms.
These
findings
manifest
that
macromolecular
carriers
exert
target
delivery
regulating
restore
impaired
function
alleviation
inflammation.
PubMed,
Journal Year:
2023,
Volume and Issue:
26(7), P. 738 - 752
Published: Jan. 1, 2023
Metabolic
syndrome
(MetS)
is
known
as
a
global
health
challenge
with
different
types
of
conditions
such
hypertension,
hyperglycemia,
the
increasing
prevalence
obesity,
and
hyperlipidemia.
Despite
much
recent
scientific
progress,
use
traditional
herbal
medicines
fewer
side
effects
worldwide.
Dendrobium,
second-largest
orchid
genus,
has
been
used
natural
source
drugs
for
treatment
MetS.
The
beneficial
including
anti-hypertension,
anti-hyperglycemia,
anti-obesity,
anti-hyperlipidemic
against
MetS
have
shown
in
evidence.
anti-oxidant
lipid-lowering
Dendrobium
modulate
hyperlipidemia
via
reducing
lipid
accumulation
maintaining
metabolism.
Restoring
pancreatic
beta
cells
regulating
insulin
signaling
pathway
are
involved
its
antidiabetic
properties.
hypotensive
contribute
to
nitric
oxide
(NO)
generation
inhibiting
extracellular
signal-regulated
kinase
(ERK)
signaling.
More
research
projects,
especially
clinical
trials,
needed
investigate
safety,
efficacy,
pharmacokinetics
patients.
This
review
article
provides,
first
time,
comprehensive
information
about
efficacy
species
Dendrobium.
described
can
be
MetS,
which
reported
various
Frontiers in Nutrition,
Journal Year:
2022,
Volume and Issue:
9
Published: Oct. 25, 2022
Background
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
the
most
prevalent
chronic
disease.
Research
on
efficacy
of
probiotics,
prebiotics,
and
synbiotics
NAFLD
patients
continues
to
be
inconsistent.
The
purpose
this
study
evaluate
effectiveness
these
microbial
therapies
NAFLD.
Methods
Eligible
randomized-controlled
trials
reporting
effect
or
in
were
searched
PubMed,
Web
Science,
Embase,
Google
scholar,
CNKI
databases
from
2020
Jul
2022.
changes
outcomes
analyzed
using
standard
mean
difference
(SMD)
95%
confidence
intervals
(CIs)
with
a
random-
fixed-effects
model
examine
therapies.
Subgroup
analysis,
influence
publication
bias
analysis
also
performed.
quality
eligible
studies
was
evaluated
Cochrane
Risk
Bias
Tool.
Results
Eleven
met
inclusion
criteria
involving
741
individuals.
Microbial
could
improve
steatosis,
total
cholesterol
(TC),
triglyceride
(TG),
low-density
lipoprotein
(LDL-c),
alanine
aminotransferase
(ALT),
alkaline
phosphatase
(ALP),
glutamyl
transpeptidase
(GGT),
homeostasis
assessment-insulin
resistance
(HOMAI-R)
(all
P
<
0.05).
But
not
ameliorate
body
mass
index
(BMI),
energy,
carbohydrate,
fat
intake,
fasting
blood
sugar,
HbA1c,
insulin,
high-sensitivity
C-reactive
protein
(hs-CRP),
hepatic
fibrosis
Conclusion
Probiotics,
supplementation
can
potentially
enzymes,
lipid
profiles,
steatosis
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
175, P. 116519 - 116519
Published: April 24, 2024
To
elucidate
the
therapeutic
effects
and
mechanisms
of
Atractylodes
macrocephala
extract
crystallize
(BZEP)
BZEP
self-microemulsion
(BZEPWR)
on
metabolic
dysfunction-associated
fatty
liver
disease
(MAFLD)
induced
by
"high
sugar,
high
fat,
excessive
alcohol
consumption"
based
gut-liver
axis
HDL/LPS
signaling
pathway.
