Paper title: Therapeutic effect of Momordica charantia on cardiomyopathy in a diabetic maternal rat model DOI

Shaimaa Elnahas,

Hend Abd El‐Halim Mansour, Mamdouh Rashad El-Sawi

et al.

Journal of Experimental Zoology Part A Ecological and Integrative Physiology, Journal Year: 2024, Volume and Issue: 341(9), P. 977 - 990

Published: July 8, 2024

Abstract Myocardial structural and functional abnormalities are hallmarks of diabetic cardiomyopathy (DCM), a chronic consequence diabetes mellitus (DM). Maternal DM affects increases the risk heart defects in mothers compared with nondiabetic mothers. Momordica charantia exhibits antidiabetic effects due to various bioactive compounds that phytochemicals, broad group includes phenolic compounds, alkaloids, proteins, steroids, inorganic lipids. Pregnant maternal rats were split into four groups: control (C), M. ‐treated (MC), type 2 (T2DM) (DM), (MC + DM) groups. Diabetes had increased serum glucose, insulin, total cholesterol, triglyceride, low‐density lipoprotein cholesterol levels reduced high‐density levels. Cardiac biomarkers such as cardiac troponin T (cTnT), creatine kinase‐myocardial band (CK‐MB), lactate dehydrogenase increased. Hormone follicle‐stimulating hormone, luteinizing progesterone, estrogen decreased significantly. Inflammatory markers interleukin 6 (IL‐6), tumor necrosis factor‐alpha (TNF‐α), vascular adhesion molecule‐1 (VCAM‐1) elevated Oxidative stress indicated malondialdehyde nitric oxide levels, while antioxidants glutathione, superoxide dismutase, catalase tissue. The apoptotic suppressor 53 (P ) cysteine aspartic protease‐3 (caspase‐3) significantly greater Histopathological analysis revealed tissue rats. extract improved diabetes‐induced changes inflammation, antioxidant structure.

Language: Английский

Moringa oleifera in a modern time: A comprehensive review of its nutritional and bioactive composition as a natural solution for managing diabetes mellitus by reducing oxidative stress and inflammation DOI

Palwasha Gul,

Jabir Khan,

Qingyun Li

et al.

Food Research International, Journal Year: 2025, Volume and Issue: 201, P. 115671 - 115671

Published: Jan. 5, 2025

Language: Английский

Citations

0
Exploring the potential of Moringa oleifera Lam in skin disorders and cosmetics: nutritional analysis, phytochemistry, geographical distribution, ethnomedicinal uses, dermatological studies and cosmetic formulations DOI
Prakrati Garg, Swati Pundir,

Aaliya Ali

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2023, Volume and Issue: 397(6), P. 3635 - 3662

Published: Dec. 6, 2023

Language: Английский

Citations

8
Reversal of Valproate‐Induced Major Salivary Gland Changes By Moringa Oleifera Extract in Rats DOI
Eda Cergel, Burçin Alev, İsmet Burcu Türkyılmaz

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(5)

Published: March 12, 2024

Abstract This study aimed to explore the potential protective impacts of Moringa oleifera extract on major alteration in salivary glands rats exposed sodium valproate (VA). Groups were defined as control, control+moringa extract, valproate, and valproate+moringa extract. Antioxidant oxidant status, activities digestive metabolic enzymes examined. VA treatment led various biochemical changes glands, including decreased levels antioxidants like glutathione, glutathione‐S‐transferase, superoxide dismutase (except for sublingual dismutase). Conversely, a decrease alpha‐amylase, alkaline acid phosphatase, lactate dehydrogenase, protease, maltase observed. The also demonstrated that induces oxidative stress, increases lipid peroxidation, sialic acid, nitric oxide glands. Total capacity was raised all except gland. electrophoretic patterns proteins similar. exhibited properties, reversing these VA‐induced due its antioxidant therapeutic attributes. research suggests moringa might serve an alternative approach individuals using experiencing gland issues, although further is necessary confirm findings human subjects.

Language: Английский

Citations

2
Exploring the Therapeutic Potential of Moringa oleifera Lam. in Traditional Chinese Medicine: A Comprehensive Review DOI Creative Commons
Shivendra Kumar, Yogesh Murti, Swamita Arora

et al.

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 12, P. 100473 - 100473

Published: June 24, 2024

Moringa oleifera Lam. (MOL), sometimes known as the drumstick tree or horseradish tree, has been extensively studied for its pharmacological properties and nutritional benefits. Recently, there an increased interest in using this versatile plant Traditional Chinese Medicine (TCM) procedures. This comprehensive analysis investigates oleifera's therapeutic potential TCM, focusing on traditional usage, phytochemical composition, activity, possible applications managing various health disorders. We looked up online databases (PubMed, Web of Science, Google Scholar, Elsevier, ACS, Springer, CNKI) novels literature keywords like oleifera, biological Moringa, Medicine. address function TCM formulations, synergistic effects with other herbal constituents, compatibility principles through a review. Furthermore, we look at problems bringing into practice, such quality control, standardisation, cultural adaptation. study emphasises need additional research clinical investigations to fully understand medicinal allow integration modern healthcare systems. However, further animal models is needed determine their efficacy safety.

Language: Английский

Citations

2
Paper title: Therapeutic effect of Momordica charantia on cardiomyopathy in a diabetic maternal rat model DOI

Shaimaa Elnahas,

Hend Abd El‐Halim Mansour, Mamdouh Rashad El-Sawi

et al.

Journal of Experimental Zoology Part A Ecological and Integrative Physiology, Journal Year: 2024, Volume and Issue: 341(9), P. 977 - 990

Published: July 8, 2024

Abstract Myocardial structural and functional abnormalities are hallmarks of diabetic cardiomyopathy (DCM), a chronic consequence diabetes mellitus (DM). Maternal DM affects increases the risk heart defects in mothers compared with nondiabetic mothers. Momordica charantia exhibits antidiabetic effects due to various bioactive compounds that phytochemicals, broad group includes phenolic compounds, alkaloids, proteins, steroids, inorganic lipids. Pregnant maternal rats were split into four groups: control (C), M. ‐treated (MC), type 2 (T2DM) (DM), (MC + DM) groups. Diabetes had increased serum glucose, insulin, total cholesterol, triglyceride, low‐density lipoprotein cholesterol levels reduced high‐density levels. Cardiac biomarkers such as cardiac troponin T (cTnT), creatine kinase‐myocardial band (CK‐MB), lactate dehydrogenase increased. Hormone follicle‐stimulating hormone, luteinizing progesterone, estrogen decreased significantly. Inflammatory markers interleukin 6 (IL‐6), tumor necrosis factor‐alpha (TNF‐α), vascular adhesion molecule‐1 (VCAM‐1) elevated Oxidative stress indicated malondialdehyde nitric oxide levels, while antioxidants glutathione, superoxide dismutase, catalase tissue. The apoptotic suppressor 53 (P ) cysteine aspartic protease‐3 (caspase‐3) significantly greater Histopathological analysis revealed tissue rats. extract improved diabetes‐induced changes inflammation, antioxidant structure.

Language: Английский

Citations

2