bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2022,
Volume and Issue:
unknown
Published: Sept. 10, 2022
SUMMARY
X-linked
adrenoleukodystrophy
(X-ALD)
is
an
inherited
progressive
metabolic
disorder
caused
by
pathogenic
variants
in
the
ABCD1
gene,
which
leads
to
accumulation
of
very
long
chain
fatty
acids
body
fluids
and
tissues
including
brain
spinal
cord.
In
absence
a
clear
genotype-phenotype
correlation
molecular
mechanisms
severe
cerebral
(cALD)
milder
adrenomyeloneuropathy
(AMN)
phenotypes
remain
unknown.
Given
our
previous
evidence
role
astrocytes
neuroinflammatory
response
X-ALD
we
investigated
profiles
derived
from
induced
pluripotent
stem
cells
(iPSC).
The
iPSCs
were
turn
generated
skin
fibroblasts
healthy
controls
patients
with
AMN
or
cALD.
cALD
exhibited
lack
acids,
hallmark
disease.
Further,
harbor
significantly
higher
phosphorylation
STAT3,
increased
Toll-like
receptor
expression
chemokine
cytokine
expression.
this
first
report
miRNA
sequencing
astrocytes,
observed
that
miR-9
was
associated
increasing
disease
severity
phenotype.
CRISPR-Cas9
knock-in
ABCD1ABCD1
gene
differentially
affected
key
molecular,
microRNA
targets
astrocytes.
Extensive
characterization
iPSC-derived
astrocyte
model
demonstrates
critical
aspects
inflammatory
mutation
can
be
further
utilized
for
exploring
contribution
differential
Cellular and Molecular Life Sciences,
Journal Year:
2024,
Volume and Issue:
81(1)
Published: Aug. 17, 2024
Parkinson's
disease
(PD)
is
the
second
most
common
neurodegenerative
disease,
and
its
hallmark
pathological
features
are
loss
of
dopaminergic
(DA)
neurons
in
midbrain
substantia
nigra
pars
compacta
(SNpc)
accumulation
alpha-synuclein
(α-syn).
It
has
been
shown
that
integrity
blood-brain
barrier
(BBB)
damaged
PD
patients,
a
large
number
infiltrating
T
cells
inflammatory
cytokines
have
detected
cerebrospinal
fluid
(CSF)
brain
parenchyma
patients
animal
models,
including
significant
change
proportion
different
CD4
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(10), P. 1677 - 1677
Published: May 15, 2025
Background/Objectives:
Alzheimer's
disease
(AD)
is
a
neurodegenerative
characterized
by
progressive
dementia
and
brain
accumulation
of
Aβ-peptide-containing
plaques,
gliosis,
neuroimmune
changes,
neurofibrillary
tangles.
Mushroom
polysaccharides
have
been
previously
reported
to
anti-neuroinflammation
activity
through
the
gut-brain
axis.
This
study
aimed
evaluate
whether
dietary
intervention
with
Phallus
atrovolvatus,
recently
identified
edible
mushroom
in
Thailand,
could
benefit
on
gut
health
alleviate
AD-related
changes.
Methods:
Male
female
6-8-month-old
littermate
wild-type
control
(C57BL/6J)
AppNL-G-F
mice
were
randomly
assigned
either
diet
or
supplemented
aqueous
extract
(MAE)
for
8
weeks
quantify
changes
body
weight,
intestine,
immune
cells,
short
chain
fatty
acids,
cytokines,
amyloid-β
(Aβ)
levels,
memory.
Results:
MAE
had
no
adverse
effects
leakiness
increased
pyruvate
levels
serum.
Splenocyte
profiling
revealed
significant
increase
frequency
IgM+,
IA_IE+,
CD14+
cells
MAE-administered
AppNL-G-Ffemale
compared
their
vehicle
controls.
AppNL-G-Fmale
that
received
showed
cytotoxic
CD8
T
within
cervical
lymph
nodes
counterparts.
Aβ
deposition
gliosis
significantly
reduced
hippocampi
MAE-supplemented
groups.
However,
feeding
did
not
alter
spatial
recognition
memory
sex
genotype
Conclusions:
Our
findings
demonstrated
administration
P.
atrovolvatus
neuroprotective
potential
against
impact
Journal of Neuroinflammation,
Journal Year:
2023,
Volume and Issue:
20(1)
Published: June 24, 2023
Chemotherapy-induced
neuropathic
pain
(CIPN)
describes
a
pathological
state
that
occurs
dose-dependently
as
side
effect
and
can
limit
or
even
impede
an
effective
cancer
therapy.
Unfortunately,
current
treatment
possibilities
for
CIPN
are
remarkably
confined
mostly
inadequate
therapeutics
themselves
consist
of
low
effectiveness
may
induce
severe
effects,
pointing
out
entity
with
emerging
need
novel
targets.
Here,
we
investigated
whether
the
highly
specific
FKBP51
inhibitor
SAFit2
reduces
paclitaxel-induced
pain.In
this
study,
used
well-established
multiple
low-dose
paclitaxel
model
to
investigate
analgesic
anti-inflammatory
properties
SAFit2.
For
purpose,
behavior
mice
was
recorded
over
14
days
mouse
tissue
then
analyzed
using
biochemical
methods.Here,
show
is
capable
reduce
mechanical
hypersensitivity
in
mice.
In
addition,
detected
shifts
lipid
levels
nervous
toward
pro-resolving
profile
counteracts
peripheral
sensitization
after
treatment.
Furthermore,
reduced
activation
astrocytes
microglia
spinal
cord
well
pain-mediating
chemokines.
Its
also
increased
cytokines
neuronal
tissues,
ultimately
leading
resolution
neuroinflammation.In
summary,
shows
antihyperalgesic
it
ameliorates
by
reducing
resolving
neuroinflammation.
Therefore,
consider
potential
drug
candidate
pain.
Cytokine,
Journal Year:
2024,
Volume and Issue:
179, P. 156617 - 156617
Published: April 16, 2024
Remitting-Relapsing
Multiple
Sclerosis
(RRMS)
and
Neuro-Behçet
Disease
(NBD)
are
two
chronic
neuro-inflammatory
disorders
leading
to
brain
damage
disability
in
young
adults.
Herein,
we
investigated
these
patients
the
cytokine
response
by
beads-based
multiplex
assays
during
early
stages
of
disorders.
Cytokine
investigations
were
carried
out
on
treatment-naive
suffering
from
RRMS
NBD
recruited
at
first
episode
clinical
relapse.
Our
findings
demonstrate
that
Cerebrospinal
Fluid
(CSF)
cells
patients,
but
not
RRMS,
secrete
significant
high
levels
IL-22
which
is
associated
with
elevated
mRNA
expression.
We
also
observed
an
increase
definite
subgroup
as
compared
probable
one,
indicating
a
clear
relationship
between
diagnostic
certainty.
Interestingly,
found
no
correlation
secretion
CSF
serum
arguing
about
intrathecal
release
CNS
patients.
Moreover,
showed
correlogram
analysis
this
doesn't
correlate
IL-17A,
IL-17F
IL-21
suggesting
secreted
Th22
Th17
Finally,
IL-6
positive
IL
6
NBD.
In
conclusion,
results
suggest
contributes
production
T
exacerbation
inflammation
within
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12110 - 12110
Published: Nov. 11, 2024
Schizophrenia
is
a
severe
neuropsychiatric
illness
of
uncertain
etiopathogenesis
in
which
antipsychotic
drugs
can
attenuate
the
symptoms,
but
patients
rarely
return
to
premorbid
level
functioning.
In
fact,
with
each
relapse,
people
living
schizophrenia
progress
toward
disability
and
cognitive
impairment.
Moreover,
our
desire
live
normal
lives,
manage
their
daily
affairs
independently,
date,
get
married,
raise
support
family.
Those
us
who
work
know
that
these
objectives
are
met
despite
novel
allegedly
improved
dopamine
blockers.
We
hypothesize
poor
outcomes
reflect
gray
matter
volume
reduction,
continues
treatment.
further
increased
gut
barrier
permeability,
due
dysfunctional
aryl
hydrocarbon
receptor
(AhR),
downregulates
protectors,
brain-derived
neurotrophic
factor
(BDNF),
interleukin-22
(IL-22),
facilitating
microbial
translocation
into
systemic
circulation,
eventually
reaching
brain.
Recombinant
human
IL-22
could
ameliorate
outcome
by
limiting
bacterial
initiating
tissue
repair.
This
short
review
examines
signal
transducer
transcription-three
(STAT3)/AhR
axis
downregulation
BDNF
subsequent
increase
permeability.
Based
on
hypothesis
presented
here,
we
discuss
alternative
interventions,
including
AhR
antagonists,
mitochondrial
transplant,
membrane
lipid
replacement,
recombinant
IL-22.
Allergology and Immunology in Pediatrics,
Journal Year:
2024,
Volume and Issue:
4, P. 31 - 39
Published: Jan. 8, 2024
Multiple
sclerosis
(MS)
is
a
chronic,
demyelinating
disease
that
leads
to
disability.
Understanding
the
etiology
of
MS
contributes
development
pathogenetic
methods
treatment,
and
search
for
informative
biomarkers
effectiveness
treatment
will
allow
patient
adjust
therapy
in
time.
The
aim
this
work
was
determine
cytokines
cytokine
profiles
predict
IFN-β1a
children
with
MS.
Materials
.
66
aged
16
[14.2–17.5]
years
who
are
on
INFß-1a
were
examined:
group
1
—
patients
exacerbation
(with
active
foci
demyelination
by
MRI),
n
=
34;
2
remission
(without
foci),
32.
content
blood
serum
assessed
using
multiplex
panel
Human
Th17
Magnetic
Bead
Panel.
Results
:
There
significant
increase
concentrations
compared
remission:
IL5,
IL6,
IL9,
IL12p70,
IL17E/IL25,
IL21,
IL28A,
GM-CSF,
TNFß.
Threshold
values
IL9
(AUC
0,785),
IL6
0,750),
TNFß
(0,740),
IL28A
0,744)
obtained
above
which
it
possible
an
patients:
3.9
pg/ml
(Sn
70.6,
Sp
71.9),
4.0
68.8),
6.6
243.0
71.9).
Cytokine
associated
T-lymphocytes
their
functions
evaluated
z-score.
Conclusions
For
first
time,
levels
demonstrated
An
proinflammatory
Th1
Th17,
as
well
Th2
Th22
has
been
shown.
use
threshold
TNFβ,
help
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2022,
Volume and Issue:
unknown
Published: Sept. 10, 2022
SUMMARY
X-linked
adrenoleukodystrophy
(X-ALD)
is
an
inherited
progressive
metabolic
disorder
caused
by
pathogenic
variants
in
the
ABCD1
gene,
which
leads
to
accumulation
of
very
long
chain
fatty
acids
body
fluids
and
tissues
including
brain
spinal
cord.
In
absence
a
clear
genotype-phenotype
correlation
molecular
mechanisms
severe
cerebral
(cALD)
milder
adrenomyeloneuropathy
(AMN)
phenotypes
remain
unknown.
Given
our
previous
evidence
role
astrocytes
neuroinflammatory
response
X-ALD
we
investigated
profiles
derived
from
induced
pluripotent
stem
cells
(iPSC).
The
iPSCs
were
turn
generated
skin
fibroblasts
healthy
controls
patients
with
AMN
or
cALD.
cALD
exhibited
lack
acids,
hallmark
disease.
Further,
harbor
significantly
higher
phosphorylation
STAT3,
increased
Toll-like
receptor
expression
chemokine
cytokine
expression.
this
first
report
miRNA
sequencing
astrocytes,
observed
that
miR-9
was
associated
increasing
disease
severity
phenotype.
CRISPR-Cas9
knock-in
ABCD1ABCD1
gene
differentially
affected
key
molecular,
microRNA
targets
astrocytes.
Extensive
characterization
iPSC-derived
astrocyte
model
demonstrates
critical
aspects
inflammatory
mutation
can
be
further
utilized
for
exploring
contribution
differential
