BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)
Published: Sept. 6, 2024
Language: Английский
Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)
Published: Jan. 13, 2024
Abstract Background Hepatocellular carcinoma (HCC) stands as a prevalent malignancy globally, characterized by significant morbidity and mortality. Despite continuous advancements in the treatment of HCC, prognosis patients with this cancer remains unsatisfactory. This study aims at constructing disulfidoptosis‑related long noncoding RNA (lncRNA) signature to probe personalized HCC. Methods The data HCC were extracted from Cancer Genome Atlas (TCGA) databases. Univariate, multivariate, least absolute selection operator Cox regression analyses performed build disulfidptosis-related lncRNAs (DRLs) signature. Kaplan–Meier plots used evaluate Functional enrichment analysis was identify key DRLs-associated signaling pathways. Spearman’s rank correlation elucidate association between DRLs immune microenvironment. function TMCC1-AS1 validated two cell lines (HEP3B HEPG2). Results We identified 11 prognostic TCGA dataset, three which selected construct DRLs. found that survival time low-risk considerably longer than high-risk patients. further observed composition subpopulations significantly different high- groups. Additionally, we sorafenib, 5-Fluorouracil, doxorubicin displayed better responses low-score group those high-score group, based on IC50 values. Finally, confirmed inhibition impeded proliferation, migration, invasion hepatocellular cells. Conclusions DRL signatures have been shown be reliable response indicator showed potential novel biomarker therapeutic target for
Language: Английский
Citations
4
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Sept. 27, 2024
Language: Английский
Citations
4
Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155939 - 155939
Published: March 1, 2025
Glioblastoma (GBM) is the most malignant tumor within central nervous system, attributed to its high-grade malignancy, propensity for recurrence, refractoriness conventional therapeutic modalities, and suboptimal efficacy of current targeted therapies. Hence, there an urgent need identify more efficacious molecular targets intervention GBM. The regulated cell death (RCD) has specific signaling factors pathways. targeting RCD considered be one effective therapies At present, cuproptosis a novel form RCD, characterized by distinct mechanism that differentiates it from apoptosis, pyroptosis, necroptosis, ferroptosis. It principal mechanisms, which include copper dependency, accumulation acylated proteins, reduction Fe-S cluster-containing proteins. These processes collectively induce proteotoxic stress, culminating in death. In previous studies, copper-ionized formulations have demonstrated cytotoxic effects on gliomas. Thus, key may able serve as new target GBM treatment. This review delves into several pivotal aspects, including discovery cuproptosis, impact homeostasis tumorigenesis, role GBM, potential therapy this article could reveal strategies
Language: Английский
Citations
0
Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)
Published: Oct. 31, 2024
Copper is an important trace element for maintaining key biological functions such as cellular respiration, nerve conduction, and antioxidant defense. Maintaining copper homeostasis critical human health, its imbalance has been linked to various diseases, especially cancer. Cuproptosis, a novel mechanism of copper-induced cell death, provides new therapeutic opportunities metal ion regulation interact with fate. This review insights into the complex mechanisms metabolism, molecular basis cuproptosis, association cancer development. We assess role cuproptosis-related genes (CRGs) associated tumorigenesis, their importance prognostic indicators targets, impact on tumor microenvironment (TME) immune response. Ultimately, this highlights interplay between copper, immunotherapy.
Language: Английский
Citations
2
Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)
Published: Dec. 8, 2023
Abstract Background Gliomas, a prevalent form of primary brain tumors, are linked with high mortality rate and unfavorable prognoses. Disulfidptosis, an innovative programmed cell death, has received scant attention concerning disulfidptosis-related lncRNAs (DRLs). The objective this investigation was to ascertain prognostic signature utilizing DRLs forecast the prognosis treatment targets glioma patients. Methods RNA-seq data were procured from Cancer Genome Atlas database. Disulfidptosis-related genes compiled prior research. An analysis multivariate Cox regression least absolute selection operator used construct risk model using six DRLs. signature’s performance evaluated via Kaplan-Meier survival curves receiver operating characteristic curves. Additionally, functional carried out GO, KEGG, single-sample GSEA investigate biological functions immune infiltration. research also tumor mutational burden, therapeutic drug sensitivity, consensus cluster analysis. Reverse transcription quantitative PCR conducted validate expression level Results A comprising developed predict High-risk patients had significantly shorter overall than low-risk robustness validated by subgroup Risk independently as indicator for Notably, displayed substantial decrease in checkpoints, proportion cells, ESTIMATE score. IC50 values different groups allowed us discern three drugs Lastly, potential clinical significance determined. Conclusions novel may provide valuable insights seeking immunotherapy targeted therapy.
Language: Английский
Citations
4
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 19, 2024
Language: Английский
Citations
1
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 137, P. 112438 - 112438
Published: June 13, 2024
Language: Английский
Citations
0
BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)
Published: Sept. 6, 2024
Language: Английский
Citations
0