Effects of traditional Chinese medicine in the treatment of patients with central serous chorioretinopathy: A systematic review and meta-analysis DOI Creative Commons

Shuting Ru,

Jian Sun,

Wanyu Zhou

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(6), P. e0304972 - e0304972

Published: June 21, 2024

Several studies have reported the efficacy of traditional Chinese medicine (TCM) for central serous chorioretinopathy (CSC), while some ophthalmologists are concerned that TCM may be a risk factor CSC as chinese herbs contain hormonal ingredients. This study aimed to evaluate and safety in treating patients with CSC. Randomized controlled trials (RCTs) observational were searched up July 10, 2023 on following biological databases without language publication time restrictions: PubMed, Ovid Medline, Embase, Cochrane Library, The National Knowledge Infrastructure Database (CNKI), Technology Periodical (VIP), Wanfang, Biomedical Literature Service System (SinoMed). Review Manager V.5.4.1 Stata 14 software used data analysis. Finally, thirty-eight finally included including 23 RCTs 15 cohort studies. meta-analysis showed compared routine treatment alone, combination can not only reduce recurrence rate (OR = 0.29, 95% CI: 0.21,0.40; I2 0%) retinal thickness (CRT) (MD - 35.63, 45.96,-25.30; 89%) CSC, but improve patients' best corrected visual acuity (BCVA) (SMD 0.86, 0.62,1.11; 77%); additionally, it has no obvious side effects 0.72, 0.39,1.34; 10%). Overall, this shows use does increase recurrence; contrary, BCVA CRT conventional treatment.

Language: Английский

The signaling pathways of selected traditional Chinese medicine prescriptions and their metabolites in the treatment of diabetic cardiomyopathy: a review DOI Creative Commons
Wencan Li, Xiang Liu, Zheng Liu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 3, 2024

Diabetic cardiomyopathy (DCM) is a myocardial-specific microvascular disease caused by diabetes that affects the structure and function of heart considered to be leading cause morbidity death in patients with diabetes. Currently, there no specific treatment or preventive drug for DCM, an urgent need develop new drugs treat DCM. Traditional Chinese medicine (TCM) has rich experience its characteristics multi-target, multi-pathway, multi-component, few side effects can effectively deal complexity long-term nature Growing evidence suggests myocardial fibrosis, inflammation, oxidative stress, apoptosis, cardiac hypertrophy, advanced glycation end product deposition were main pathologic mechanisms According pathological mechanism this study revealed potential metabolites prescriptions TCM against DCM from perspective signaling pathways. The results showed TGF-β/Smad, NF-κB, PI3K/AKT, Nrf2, AMPK, NLRP3, Wnt/β-catenin pathways key aim was summarize update screen targets candidates provide ideas more experimental clinical use

Language: Английский

Citations

28
Study on the mechanism of plant metabolites to intervene oxidative stress in diabetic retinopathy DOI Creative Commons
Tianyao Gong, Dongmei Wang, Jinyan Wang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 5, 2025

Diabetic retinopathy is the main microvascular complication of diabetes and first blinding eye disease in working-age population. Oxidative stress an important pathogenesis diabetic retinopathy. Plant metabolites can be divided into two types: primary secondary metabolites, are active components sources for developing new drugs. It has unique effect treatment However, research on intervention mechanism plant still relatively shallow, which limit application metabolites. With deepening research, more have been reported to play a role treating through anti-oxidative stress, including polyphenols, polysaccharides, saponins, alkaloids, etc. Therefore, this article reviewed potential last 10 years elucidated their action. We hope provide some references valuable resources development drugs

Language: Английский

Citations

1
A Review on Diabetic Retinopathy DOI
Vijender Kour, Jayshree Swain, Jaspreet Singh

et al.

Current Diabetes Reviews, Journal Year: 2023, Volume and Issue: 20(6)

Published: Oct. 23, 2023

Diabetic retinopathy is a well-recognised microvascular complication of diabetes and among the leading cause blindness all over world. Over last decade, there have been advances in diagnosis diabetic macular edema. At same time, newer therapies for management evolved. As result these advances, decline severe vision loss due to has witnessed some developing countries. However, steady increase number people affected with diabetes, expected rise further coming years. Therefore, it prudent identify retinopathy, timely intervention needed decrease burden loss. An effort made review existing knowledge regarding this article summarize present treatment options retinopathy.

Language: Английский

Citations

12
An evidence mapping study based on systematic reviews of traditional Chinese medicine (TCM) for diabetic retinopathy DOI Creative Commons
Juan Ling,

Zhuolin Xie,

Xiangxia Luo

et al.

Systematic Reviews, Journal Year: 2025, Volume and Issue: 14(1)

Published: Feb. 20, 2025

Diabetic retinopathy (DR) is a leading cause of vision impairment and blindness among individuals with diabetes. Traditional Chinese medicine (TCM) has been explored as an alternative treatment for DR, but the quality evidence remains uncertain. A comprehensive mapping study necessary to synthesize existing SRs, identify gaps in literature, highlight areas requiring further research. This aims evaluate reporting methodological SRs on TCM DR assess effectiveness interventions using evidence-mapping approach. search major biomedical databases relevant published up November 2023. The included was assessed Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines, while evaluated Assessment Multiple 2 (AMSTAR 2) tool. total 51 involving 131,084 participants were analysis. Evidence indicated that relatively effective treating DR. However, standards these generally suboptimal. According AMSTAR assessment, only one SR (2%) rated high quality, 29 (56.9%) moderate 20 (39.2%) low critically quality. While all studies adequately reported PICO components, risk bias statistical methods, none provided information funding sources. Furthermore, list excluded reasons, eight (15.7%) documented pre-specified protocols. Common deficiencies incomplete protocol registration details, unclear review rationales, insufficient presentation outcome data. highlights potential benefits identifying significant literature. Although show overall Future research should focus addressing gaps, particularly such disclosure rigor, enhance reliability

Language: Английский

Citations

0
Effective Components of Panax notoginseng–Salvia miltiorrhiza in the Treatment of Melasma and Its Experimental Study DOI Creative Commons
Yukun Wei,

Xufeng Yu,

Jing Zhao

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Purpose: The main purpose of this study was to predict and verify the active ingredients Panax notoginseng–Salvia miltiorrhiza in melasma based on network pharmacology analysis experimental verification. Materials methods: notoginseng–Salviae miltiorrhizae investigated by pharmacology, GEO database analysis, molecular docking techniques screen its ingredients. components were further validated an vitro α-melanin-induced B16F10 melanoma cell model vivo UV irradiation combined with a progesterone injection-induced rat model. Results: Network showed that salvianolic acid B might be key ingredient. In cellular experiments revealed inhibits tyrosinase activity cells at concentrations 60–90 nmol/mL. animal found TYR, MDA, TNF-α decreased skin serum rats group low-, medium-, high-dose groups B, expression GSH-Px SOD increased. best therapeutic effect. Conclusion: study, collectively show slows down process inhibiting lipid peroxidation organism, increasing antioxidant capacity skin, decreasing tyrosinase, providing anti-inflammation. This highlights successful application provides scientific basis for clinical citation treating melasma.

Language: Английский

Citations

0
Yi-qi-yang-yin decoction ameliorates diabetic retinopathy: New and comprehensive evidence from network pharmacology, machine learning, molecular docking and molecular biology experiment DOI
Dong Huang, Siwei Wang, Yuan Gao

et al.

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2025, Volume and Issue: 260, P. 116794 - 116794

Published: March 6, 2025

Language: Английский

Citations

0
Unveiling the molecular mechanisms of stigmasterol on diabetic retinopathy: BNM framework construction and experimental validation DOI Creative Commons

Hongrong Zhang,

Yufan Li, Qi Xu

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: May 9, 2025

Background Diabetic retinopathy (DR), one of the most common complications diabetes, severely impacts patients’ quality life. The combined use traditional Chinese medicines Astragalus, Fructus ligustris, and Cornus officinalis has yielded considerable therapeutic effects in clinical DR treatment. Methods In this study, a multimodule framework (BNM) encompassing bioinformatics, network pharmacology, machine learning (ML) based on molecular fingerprints was innovatively developed to thoroughly investigate mechanisms medicine treating DR. Results A total 40 active components 12 core targets were identified. Enrichment analysis identified key pathways such as VEGF signaling pathway, TNF pathway HIF-1 pathway. Prediction models using targets, PPARG, constructed from GEO database validated via immune infiltration docking, revealing that PPARG may be potential target for Moreover, component medicine, stigmasterol, ML model fingerprints. vivo experiments demonstrated stigmasterol can regulate glucose lipid metabolism, improve systemic inflammatory levels, ameliorate ocular vascular changes by modulating expression PPARG. Conclusion BNM suggests an important treatment DR, with its mechanism potentially related VEGF/VEGFR

Language: Английский

Citations

0
NEDD4L Promotes I κ B α Ubiquitination and Degradation in the Pathogenesis of Diabetic Retinopathy DOI
Cui Li,

Jingxue Ma

Current Eye Research, Journal Year: 2023, Volume and Issue: 49(1), P. 62 - 72

Published: Sept. 28, 2023

The dysregulation of NF-κB signaling activity plays an important role in the pathogenesis diabetic retinopathy (DR). This study explored association between NEDD4L and IκBα DR.

Language: Английский

Citations

8
The role of Keap1-Nrf2 signaling pathway during the progress and therapy of diabetic retinopathy DOI
Jiawen Chen, Qi Wang, Ruiyan Li

et al.

Life Sciences, Journal Year: 2023, Volume and Issue: 338, P. 122386 - 122386

Published: Dec. 28, 2023

Language: Английский

Citations

6
Suppression of retinal neovascularization by intravitreal injection of cryptotanshinone DOI Creative Commons
Yang Yu,

Xun Qin,

Xi Chen

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 720, P. 150065 - 150065

Published: May 7, 2024

Neovascular eye diseases, including proliferative diabetic retinopathy and of prematurity, is a major cause blindness. Laser ablation intravitreal anti-VEGF injection have shown their limitations in treatment retinal neovascularization. Identification new therapeutic strategies urgent need. Our study aims to assess the effects Cryptotanshinone (CPT), natural compound derived from Salvia miltiorrhiza Bunge, retina neovascularization explore its potential mechanism. demonstrated that CPT did not tissue toxicity at tested concentrations. Intravitreal injections reduced pathological angiogenesis promoted physical oxygen-induced (OIR) model. improve visual function OIR mice cell apoptosis. Moreover, we also revealed diminishes expression inflammatory cytokines retina. In vitro, administration effectively inhibited endothelial cells proliferation, migration, sprouting, tube formation induced by stimulation human vascular (HRVECs) with VEGF165. Mechanistically, blocking phosphorylation VEGFR2 downstream targeting pathway. After all, findings exhibits potent anti-angiogenic anti-inflammatory mice, it has for neovascular diseases.

Language: Английский

Citations

2