Impact of dexmedetomidine on mortality in critically ill patients with acute kidney injury: a retrospective propensity score matching analysis DOI Creative Commons
Wenting Wang, Yu Jin, Peiyao Zhang

et al.

BMJ Open, Journal Year: 2023, Volume and Issue: 13(11), P. e073675 - e073675

Published: Nov. 1, 2023

Objectives This study sought to estimate the effect of dexmedetomidine (DEX) administration on mortality in critically ill patients with acute kidney injury (AKI). Design A retrospective cohort study. Setting The sourced its data from Multiparameter Intelligent Monitoring Intensive Care Database IV (MIMIC-IV), a comprehensive database intensive care unit patients. Participants total 15 754 AKI were enrolled MIMIC-IV database. Primary and secondary outcome was in-hospital 180-day mortality. Results included our analysis. We found that DEX use decreased risk by 38% (HR 0.62, 95% CI 0.55 0.70) 23% 0.77, 0.69 0.85). After adjusting for confounding factors, can reduce all three stages Conclusions Our suggests significantly correlates risk-adjusted Nonetheless, future randomised controlled trials are warranted validate findings.

Language: Английский

Aspirin is associated with improved outcomes in patients with sepsis-induced myocardial injury: An analysis of the MIMIC-IV database DOI

Yiming Dong,

Shuxing Wei, 阳 刘

et al.

Journal of Clinical Anesthesia, Journal Year: 2024, Volume and Issue: 99, P. 111597 - 111597

Published: Sept. 7, 2024

Language: Английский

Citations

7
Aspirin is associated with improved 30-day mortality in patients with sepsis-associated liver injury: a retrospective cohort study based on MIMIC IV database DOI Creative Commons
Jianbao Wang, Xuemei Hu, Susu Cao

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 4, 2025

Background Sepsis-associated liver injury (SALI) is a common complication in sepsis patients, significantly affecting their prognosis. Previous studies have shown that aspirin can improve the prognosis of septic patients. However, there currently lack clinical evidence supporting use treatment SALI. Therefore, we conducted this study to explore association between and patients with Methods The were obtained from Medical Information Mart for Intensive Care IV (MIMIC-IV) database, version 3.0. primary outcome was 30-day all-cause mortality. Baseline characteristics non-aspirin groups balanced using propensity score matching (PSM). Kaplan-Meier survival curve Cox regression analysis used investigate Results Of 657 SALI study, 447 (68%) had not during hospitalization, whereas 210 (32%) had. After PSM, mortality 33.1% group 21% group, indicating reduced risk (HR, 0.57; 95% CI, 0.37–0.90; P = 0.016). Similarly, results multivariable inverse probability weighting (IPW) showed that, compared lower (Multivariable analysis: HR, 0.69; 0.48–0.99; 0.047; IPW: 0.62; 0.43–0.89; 0.010). Conclusion Aspirin reduce regardless dose or timing administration. careful assessment based on individual differences essential ensure safety effectiveness use.

Language: Английский

Citations

0
Investigating the role of aspirin on the mortality risk of sepsis-associated encephalopathy: a retrospective study DOI Creative Commons
Fengzhen Huang,

Jiping Yi,

Qiuli Li

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Background Sepsis-associated encephalopathy (SAE) is one of the most common complications sepsis. Aspirin can serve as a promising therapeutic candidate and help improve patient outcomes in sepsis its complications. However, efficacy safety aspirin on SAE remains largely unexplored. Methods Patients for this retrospective study were collected from MIMIC-IV (version 3.0). Propensity score matching (PSM) was used to balance baseline characteristics between no group group. The association therapy mortality risk in-hospital, 30-day, 60-day, 90-day, 180-day analyzed by Cox proportional hazards model Kaplan–Meier method. E -value analysis evaluate potential influence unmeasured or unknown confounding factors. Subgroup applied explore differences effects clinical across these various groups. Results Our recruited 4,707 patients total, 2,518 enrolled after PSM. rate consistently significant lower than that curves revealed received exhibited notably higher survival compared those who did not. gastrointestinal hemorrhage had difference two Additionally, pre-ICU group, in-ICU decreased significantly high-dose experienced low-dose Conclusion could reduce 180-day, without increasing hemorrhage. benefits observed persisted regardless exposure timing.

Language: Английский

Citations

0
Metabolic syndrome induces benefits in mice experiencing severe sepsis, comparable to the effects of low-dose aspirin pretreatment in septic mice lacking metabolic syndrome DOI

Raquel Pires Nakama,

Lucas Felipe dos Santos,

Leonardo Berto-Pereira

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 139, P. 112694 - 112694

Published: July 17, 2024

Language: Английский

Citations

3
Incidence and predictors of acute kidney injury after elective surgery for lumbar degenerative disease: A 13-year analysis of the US Nationwide Inpatient Sample DOI Creative Commons
Yueh-Ying Hsieh, Lien-Chen Wu, I‐Chun Chen

et al.

Journal of the Chinese Medical Association, Journal Year: 2024, Volume and Issue: 87(4), P. 400 - 409

Published: Feb. 9, 2024

Background: Acute kidney injury (AKI) is a severe postoperative complication associated with poor clinical outcomes, including the development of chronic disease (CKD) and death. This study aimed to investigate incidence determinants AKI following elective surgeries for degenerative lumbar spine disease. Methods: All patient data were extracted from US Nationwide Inpatient Sample database. After surgery, AKI’s risk factors identified ICD-9 ICD-10 codes defined disease, fusion, decompression, AKI. The cohort was categorized by type that is, decompression alone or spinal fusion. Regression analysis used identify associations between organized surgery type. Results: after fusion 1.1% 1.8%, respectively. However, in United States rising. strongest predictor underlying CKD, which an 9.0- 12.9-fold more significant than subjects without comorbid CKD. In this setting, older age, congestive heart failure, anemia, obesity, coagulopathy hospital-acquired infections also strong predictors contrast, long-term aspirin/anticoagulant usage lowered risk. Conclusion: Findings inform stratification may help optimize treatment decisions care planning

Language: Английский

Citations

1
Impact of dexmedetomidine on mortality in critically ill patients with acute kidney injury: a retrospective propensity score matching analysis DOI Creative Commons
Wenting Wang, Yu Jin, Peiyao Zhang

et al.

BMJ Open, Journal Year: 2023, Volume and Issue: 13(11), P. e073675 - e073675

Published: Nov. 1, 2023

Objectives This study sought to estimate the effect of dexmedetomidine (DEX) administration on mortality in critically ill patients with acute kidney injury (AKI). Design A retrospective cohort study. Setting The sourced its data from Multiparameter Intelligent Monitoring Intensive Care Database IV (MIMIC-IV), a comprehensive database intensive care unit patients. Participants total 15 754 AKI were enrolled MIMIC-IV database. Primary and secondary outcome was in-hospital 180-day mortality. Results included our analysis. We found that DEX use decreased risk by 38% (HR 0.62, 95% CI 0.55 0.70) 23% 0.77, 0.69 0.85). After adjusting for confounding factors, can reduce all three stages Conclusions Our suggests significantly correlates risk-adjusted Nonetheless, future randomised controlled trials are warranted validate findings.

Language: Английский

Citations

1