Medications that Regulate Gastrointestinal Transit Influence Inpatient Blood Glucose

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 2, 2024

Objective: A multitude of factors affect a hospitalized individual's blood glucose (BG), making BG difficult to predict and manage. Beyond medications well established alter BG, such as beta-blockers, there are likely many with undiscovered effects on variability. Identification these the strength timing relationships has potential improve glycemic management patient safety. Materials Methods: EHR data from 103,871 inpatient encounters over 8 years within large, urban health system was used extract 500 medications, laboratory measurements, clinical predictors BG. Feature selection performed using an optimized Lasso model repeated 5-fold cross-validation 80% training set, followed by linear mixed regression evaluate statistical significance. Significant medication were then evaluated for novelty against comprehensive adverse drug event database. Results: We found 29 statistically significant features associated BG; 24 including 10 not previously documented The remaining five Black/African American race, history type 2 diabetes mellitus, prior (mean last) creatinine. Discussion: unexpected several agents involved in gastrointestinal motility, supported available studies. This study may bring light use caution individuals hyper- or hypoglycemia. Further investigation candidates is needed enhance utility findings. Conclusion: uniquely identifies transit be that recognized practice.

Language: Английский

Dysfunctional K+ Homeostasis as a Driver for Brain Inflammation

Encyclopedia, Journal Year: 2024, Volume and Issue: 4(4), P. 1681 - 1699

Published: Nov. 18, 2024

The central nervous system (CNS) relies on precise regulation of potassium ion (K+) concentrations to maintain physiology. This involves complex cellular and molecular mechanisms that work in concert regulate both intracellular extracellular K+ levels. Inflammation, a key physiological response, encompasses series cell-specific events leading inflammasome activation. Perturbations K+-sensitive processes can result either chronic or uncontrolled inflammation, highlighting the intricate relationship between homeostasis inflammatory signalling. review explores targets influence have been implicated cascades, offering potential therapeutic avenues for managing inflammation. We examine common across different cell types, providing comprehensive overview interplay inflammation CNS. By elucidating these mechanisms, we identify leads drug discovery programmes aimed at modulating responses. Additionally, highlight consequences targeting individual entities purposes, emphasizing need nuanced approach developing anti-inflammatory strategies. considers current knowledge within CNS, critical insights into underpinnings interventions. Our findings underscore importance considering development targeted therapies conditions

Language: Английский