Panoptosis – new frontier in research in head neck cancer DOI Creative Commons
Shrikant B. Mali

Oral Oncology Reports, Journal Year: 2024, Volume and Issue: 10, P. 100310 - 100310

Published: April 5, 2024

Head and neck squamous cell carcinoma (HNSCC) is a common cancer that can develop resistance to therapeutic approaches, including chemotherapy, targeted therapy, immunotherapy. PANoptosis, non-apoptotic death mechanism, has been identified as potential solution. PANoptosis highly coordinated dynamically balanced programmed inflammatory pathway combines the main features of pyroptosis, apoptosis, necroptosis. It linked development multiple systemic diseases in human body, infectious diseases, cancer, neurodegenerative diseases. The innate immune system provides first line defense against cellular perturbations, elicited response microbial infections or alterations homeostasis. Programmed (PCD) key mechanism for studying anticancer drugs significant impact on management cancer. Recent research revealed existence distinct PCD modality known which controlled by complex PANoptosome complexes built combining elements from different pathways. No single route sufficient explain all physiologic effects seen PANoptosis. Numerous studies have demonstrated successfully stop cells growing, proliferating, developing drug resistance, changing focus therapy.

Language: Английский

Exploring beyond Common Cell Death Pathways in Oral Cancer: A Systematic Review DOI Creative Commons
Leonardo de Oliveira Siquara da Rocha, Éverton Freitas de Morais, Lilianny Querino Rocha de Oliveira

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(2), P. 103 - 103

Published: Feb. 6, 2024

Oral squamous cell carcinoma (OSCC) is the most common and lethal type of head neck cancer in world. Variable response acquisition resistance to traditional therapies show that it essential develop novel strategies can provide better outcomes for patient. Understanding cellular molecular mechanisms death control has increased rapidly recent years. Activation pathways, such as emerging forms non-apoptotic programmed death, including ferroptosis, pyroptosis, necroptosis, NETosis, parthanatos, mitoptosis paraptosis, may represent clinically relevant therapeutic opportunities. This systematic review summarizes recently described OSCC, highlighting their potential informing diagnosis, prognosis treatment. Original studies explored any selected deaths OSCC were included. Electronic search, study selection, data collection risk bias assessment tools realized. The literature search was carried out four databases, extracted from 79 articles categorized grouped by death. Ferroptosis, necroptosis represented main studies, with links immunity inflammatory responses, progression OSCC. Harnessing these pathways be useful patient-specific individualized therapy. We perspectives on how different types integrated decision prognosis, treatment

Language: Английский

Citations

8
From Genes to Metabolites: HSP90B1’s Role in Alzheimer’s Disease and Potential for Therapeutic Intervention DOI Creative Commons
Cheng Huang, Ying Liu, Shuxin Wang

et al.

NeuroMolecular Medicine, Journal Year: 2025, Volume and Issue: 27(1)

Published: Jan. 6, 2025

Language: Английский

Citations

0
A bibliometric analysis of programmed cell death in oral cancer literature: research patterns and emerging trends (2000–2024) DOI Creative Commons

Wenli Gu

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 22, 2025

Language: Английский

Citations

0
Exploring cell death pathways in oral cancer: mechanisms, therapeutic strategies, and future perspectives DOI Creative Commons

Chenyi Zhao

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 26, 2025

Oral squamous cell carcinoma (OSCC) represents a significant global health challenge, characterized by aggressive progression and poor therapeutic response despite advances in treatment modalities. This review provides comprehensive analysis of diverse death mechanisms OSCC, encompassing traditional pathways (apoptosis, autophagy, necrosis), newly (ferroptosis, pyroptosis, necroptosis), emerging (cuproptosis, anoikis, parthanatos, entosis). By examining the molecular basis these pathways, particularly crucial roles p53 signaling miRNA regulation, we highlight how their dysregulation contributes to resistance tumor progression. The synthesizes recent evidence demonstrating complex interplay between ten distinct impact on microenvironment immune response. We evaluate innovative approaches that target including novel small molecules, combination strategies, immunomodulatory treatments exploit specific enhance efficacy. Special attention is given personalized medicine strategies consider individual characteristics pathway profiles. integrating current challenges with future research directions, this framework for developing more effective can leverage multiple overcome therapy improve outcomes oral cancer patients.

Language: Английский

Citations

0
Panoptosis – new frontier in research in head neck cancer DOI Creative Commons
Shrikant B. Mali

Oral Oncology Reports, Journal Year: 2024, Volume and Issue: 10, P. 100310 - 100310

Published: April 5, 2024

Head and neck squamous cell carcinoma (HNSCC) is a common cancer that can develop resistance to therapeutic approaches, including chemotherapy, targeted therapy, immunotherapy. PANoptosis, non-apoptotic death mechanism, has been identified as potential solution. PANoptosis highly coordinated dynamically balanced programmed inflammatory pathway combines the main features of pyroptosis, apoptosis, necroptosis. It linked development multiple systemic diseases in human body, infectious diseases, cancer, neurodegenerative diseases. The innate immune system provides first line defense against cellular perturbations, elicited response microbial infections or alterations homeostasis. Programmed (PCD) key mechanism for studying anticancer drugs significant impact on management cancer. Recent research revealed existence distinct PCD modality known which controlled by complex PANoptosome complexes built combining elements from different pathways. No single route sufficient explain all physiologic effects seen PANoptosis. Numerous studies have demonstrated successfully stop cells growing, proliferating, developing drug resistance, changing focus therapy.

Language: Английский

Citations

0