Pharmacological effects of Astragalus polysaccharides in treating neurodegenerative diseases

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 2, 2024

widely used in traditional Chinese medicine, exhibits multiple pharmacological effects, including immune stimulation, antioxidation, hepatoprotection, diuresis, antidiabetes, anticancer, and expectorant properties. Its main bioactive compounds include flavonoids, triterpene saponins, polysaccharides. Astragalus polysaccharides (APS), one of its primary components, have been shown to possess a variety activities, such as antioxidant, immunomodulatory, anti-inflammatory, antitumor, antidiabetic, antiviral, hepatoprotective, anti-atherosclerotic, hematopoietic, neuroprotective effects. This review provides comprehensive summary the molecular mechanisms therapeutic effects APS treating neurodegenerative diseases, Alzheimer's disease (AD), Parkinson's (PD), sclerosis (MS). It discusses how improve insulin resistance, reduce blood glucose levels, enhance cognitive function, Aβ accumulation neuronal apoptosis by modulating various pathways Nrf2, JAK/STAT, Toll, IMD. For PD, protect neurons stabilize mitochondrial function inhibiting ROS production promoting autophagy through PI3K/AKT/mTOR pathway. also oxidative stress neurotoxicity induced 6-hydroxydopamine, showcasing their In MS, alleviate symptoms suppressing T cell proliferation reducing pro-inflammatory cytokine expression via PD-1/PD-Ls promote myelin regeneration activating Sonic hedgehog signaling pathway fostering differentiation neural stem cells into oligodendrocytes. article emphasizes significant activities APS, highlighting potential promising candidates for treatment diseases.

Language: Английский

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Antidepressant potential of total flavonoids from Astragalus in a chronic stress mouse model: Implications for myelination and Wnt/β-catenin/Olig2/Sox10 signaling axis modulation

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 325, P. 117846 - 117846

Published: Jan. 30, 2024

Language: Английский

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Optimization of the Zhou Tian Formula extraction technology based on AHP‐CRITIC method and analysis of transfer efficiency of key components based on HPLC fingerprinting

Phytochemical Analysis, Journal Year: 2024, Volume and Issue: 35(4), P. 873 - 888

Published: Feb. 17, 2024

Abstract Introduction Zhou Tian Formula (ZTF) is an antidepressant traditional Chinese medicine utilized widely in clinical settings for the treatment of patients with depression. However, shortcomings persist its extraction technology and quality control. Objective This study aimed to propose a methodology ZTF based on analytic hierarchy process (AHP)–criteria importance through intercriteria correlation (CRITIC) method establish control framework efficient transfer index components. Method Firstly, we analyzed chemical components determined optimal technology. Secondly, calculated efficiency during conversion water decoction extract powder subsequently granules. Thirdly, established HPLC fingerprints 15 batches decoction, powder, We employed SIMCA software analyze chemicals responsible variations among different Results process. The average ferulic acid, puerarin, mirificin, isoferulic calycosin granules exceeded 41%. exhibited similarity exceeding 0.890. Variable projection values indicated that calycosin, puerarin were primary contributors variations. Conclusions AHP‐CRITIC method, coupled orthogonal array design, could be used exploring In addition, rules governing from granules, applied evaluation assessment ZTF.

Language: Английский

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Unveiling the Phytochemical Diversity and Bioactivity of Astragalus melanophrurius: A First Report Integrating Experimental and In Silico Approaches

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 103 - 103

Published: Jan. 15, 2025

Background: The genus Astragalus is renowned for its diverse bioactive potential, yet the chemical composition and biological properties of melanophrurius remain inadequately explored. This study aimed to investigate profile, antioxidant capacity, enzyme inhibitory activities methanol extracts from various plant parts A. melanophrurius. Methods: Methanol were obtained leaves, stems, flowers, roots, aerial portions was determined using LC-ESI-MS/MS, focusing on key phytochemicals such as hyperoside, kaempferol, 4-hydroxybenzoic acid, chlorogenic acid. Antioxidant assessed via DPPH, ABTS, FRAP assays, while evaluated against α-amylase tyrosinase. In silico molecular docking analyses conducted explore interactions between major compounds target enzymes. Results: leaf extract exhibited highest total phenolic flavonoid contents, correlating with superior activities, achieving IC50 values 16.55 mg/mL, 4.58 3.07 mg/mL in respectively. root demonstrated notable (IC50 = 2.99 mg/mL) tyrosinase 1.34 suggesting potential applications diabetes hyperpigmentation management. Molecular revealed stable complexes hyperoside kaempferol enzymes, supporting their roles observed bioactivities. Conclusions: highlights bioactivity extracts, particularly leaves therapeutic potential. Future research should focus isolating active conducting vivo studies confirm efficacy elucidate mechanisms action.

Language: Английский

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Advancements in the Research of Astragalus membranaceus for the Treatment of Colorectal Cancer

The American Journal of Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 28

Published: Jan. 29, 2025

Colorectal cancer, characterized by its high incidence, concealed early symptoms, and poor prognosis at advanced stages, ranks as the third leading cause of cancer-related deaths worldwide. Astragalus membranaceus (AM) refers to dried roots (Fisch.) Bge. var. mongholicus (Bge.) Hsiao In theory Traditional Chinese Medicine (TCM), it is believed have functions tonifying qi lifting yang, well generating body fluids nourishing blood. It can effectively treat cancer caused deficiency vital energy susceptibility external diseases. Modern research has confirmed that active components AM, including polysaccharides, flavonoids (formononetin calycosin), saponins (Astragaloside I Astragaloside III), nanovesicles, are effective in treatment colorectal cancer. The mechanisms mainly involve inducing apoptosis, inhibiting tumor angiogenesis metastasis cells, regulating cell cycle microenvironment, reversing drug resistance. Moreover, offers a synergistic enhancement when used combination with chemotherapy, radiotherapy, targeted therapy, or surgical treatment. AM also great potential treating combined other herbs. This review summarizes relevant findings on main pharmacological effects molecular mechanisms, aiming provide guidance for development new drugs, offer direction conduct more related promoting application AM.

Language: Английский

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Astragalus injection inhibits the growth of osteosarcoma by activating cytotoxic T lymphocyte and targeting CTSL

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119607 - 119607

Published: March 1, 2025

Language: Английский

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Effects of arbuscular mycorrhizal fungi on flavonoid content in Astragali Radix cultivated in cadmium-contaminated soils

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 24, 2025

Introduction As bioactive components in Astragali Radix (AR), flavonoids can promote hematopoiesis and have hypolipidemic properties, among others, they are easily affected by environmental factors. Arbuscular mycorrhizal fungi (AMF) influence flavonoid synthesis plants exposed to heavy metals expanding the root absorption area establish a reciprocal symbiotic relationship with most plants. Methods We investigated effects of Funneliformis mosseae time on total key monomers (calycosin, calycosin-7-glucoside, formononetin, ononin) AR cadmium (Cd) using pot experiment. The treatments consisted non-inoculation F. inoculation. A two-way analysis variance Duncan’s test were conducted. Results Shoot decreased ( p < 0.05) at 60 (20.5%) 90 d (18.3%), while formononetin (83.4%) 120 d; conversely, calycosin-7-glucoside increased inoculation, although over from regardless calycosin Root 15.2% d, then 23.5% along increases (117.1%) ononin (59.6%) (21.2%) which under colonization rate, shoot Cd, C, P, H, C/N ratio, significantly flavonoids, Cd accounted for 90.0% variation, may be associated its impact synthase. variation was influenced S, biomass, N, suggesting that AMF regulation vary between organs. Calycosin-7-glucoside phenylalanine ammonia-lyase (a gene synthesis). Overall, led significant calycosin-7-glucoside. higher shoots than roots, indicating annual utilized medicinal purposes Discussion These results provide insights into enhancement quality grown Cd-contaminated soils, long-term varying levels should further investigated.

Language: Английский

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Kumatakenin alleviates depressive-like behaviors by suppressing excessive autophagy in hippocampus via ATG5

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177688 - 177688

Published: April 1, 2025

Language: Английский

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Astragalus polysaccharide modulates the gut microbiota and metabolites of patients with major depressive disorder in an in vitro fermentation model: a pilot study

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 28, 2025

Previous studies have found that Astragalus Polysaccharide (APS) and Lactobacillus plantarum PS128 (PS128) potential antidepressant effects, but their effects on the gut microbiota metabolites of major depressive disorder (MDD) are still unclear. We examined effect APS first-episode drug naïve MDD patients using in vitro fermentation, further explored whether could enhance utilization ability APS. Fresh fecal samples from 15 were collected, analyzed for differences gas production, microbiota, tryptophan (Trp) related after 48 h fermentation. fermentation increased abundance Bifidobacterium decreased Lachnoclostridium ( p < 0.05). also total production levels indole lactic acid (ILA), Trp, 5-hydroxytryptophan (5-HTP) Compared with APS, synbiotics 0.05), reduced percentages CO 2 , H S to some extent ILA, 5-HTP, although not statistically significant > Correlation analysis showed was positively correlated Trp 5-HTP; On contrary, negatively 5-HTP. All these results suggest regulate structure patients; synbiotic reduce shows limited modulate or patients.

Language: Английский

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Mechanism of Astragalus mongholicus Bunge ameliorating cerebral ischemia-reperfusion injury: Based on network pharmacology analysis and experimental verification

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 329, P. 118157 - 118157

Published: April 6, 2024

Language: Английский

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