The Role of Ferroptosis in Inflammatory Bowel Disease: Mechanisms and Therapeutic Implications DOI Open Access
Quanshu Yan

Qeios, Journal Year: 2024, Volume and Issue: 6(4)

Published: April 12, 2024

Inflammatory Bowel Disease (IBD), encompassing Crohn's disease and ulcerative colitis, is characterized by chronic inflammation of the gastrointestinal tract, with an increasing incidence worldwide. Recent advancements in cellular biology have identified ferroptosis, a form programmed cell death driven iron-dependent lipid peroxidation, as critical player pathology IBD. This article reviews current understanding ferroptosis its distinctive mechanisms, including role GPx4, Nrf2-HO-1 pathways, iron metabolism context It also examines dual nature intestinal health disease, contributing to both physiological functions pathological processes through oxidative stress inflammation. The implications epithelial death, barrier function, immune response are discussed, highlighting potential novel therapeutic target. Despite promising insights, underscores need for further research elucidate complex mechanisms IBD translate these findings into effective strategies. emerging evidence positions at crossroads metabolic, inflammatory, offering unique perspective on interplay between nutrition, genetics, immunity disease.

Language: Английский

Efficacy and Safety Assessment of Intrathoracic Perfusion Chemotherapy Combined with immunological factor Interleukin-2 in the Treatment of Advanced Non-Small Cell Lung Cancer: A Retrospective Cohort Study DOI Creative Commons
Qiang Cao, Jinyi Zhu, Xinyan Wu

et al.

Journal of Cancer, Journal Year: 2024, Volume and Issue: 15(7), P. 2024 - 2032

Published: Jan. 1, 2024

Objective: This study evaluated the efficacy and safety of gemcitabine oxaliplatin intrathoracic perfusion chemotherapy (IPCGOR) regimen combined with interleukin-2 (IL-2) for advanced non-small cell lung cancer (NSCLC).Methods: We conducted a retrospective analysis 460 NSCLC patients from Yunnan Province Early Cancer Diagnosis Treatment Project (June 2020-October 2022), assessing IPCGOR IL-2 combination.Outcomes were measured based on RECIST 1.1 criteria, focusing objective response rate (ORR), disease control (DCR), median progression-free survival (mPFS), overall (MOS), treatment safety.Results: The demonstrated an ORR 67.4%, DCR 97.4%, mPFS 8.5 months, MOS 12.5 months.14 underwent successful surgery post-treatment.Common adverse reactions manageable, no treatment-related deaths reported. Conclusion:The shows promising tolerable profile NSCLC.These findings suggest its potential as reference treating NSCLC.However, study's nature single-center design pose limitations.Future research should focus prospective studies, randomized controlled trials, long-term outcome assessments, particularly in diverse patient subgroups, to further validate refine clinical application this regimen.

Language: Английский

Citations

16
Mechanisms of action of the BCL-2 inhibitor venetoclax in multiple myeloma: a literature review DOI Creative Commons
Qiang Cao, Xinyan Wu, Qi Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 6, 2023

Abnormal cellular apoptosis plays a pivotal role in the pathogenesis of Multiple Myeloma (MM). Over years, BCL-2, crucial anti-apoptotic protein, has garnered significant attention MM therapeutic research. Venetoclax (VTC), small-molecule targeted agent, effectively inhibits promoting programmed death cancerous cells. While VTC been employed to treat various hematological malignancies, its particular efficacy showcased potential for broader clinical applications. In this review, we delve into intricacies how modulates cells by targeting BCL-2 and overarching influence protein family regulation. Our findings highlight nuanced interplay between VTC, MM, offering insights that may pave way optimizing strategies. Through comprehensive analysis, aim lay solid groundwork future explorations VTC’s applications profound effects on apoptosis.

Language: Английский

Citations

26
Therapeutic efficacy of rare earth carbonate with chemoradiotherapy in late-stage non-small cell lung cancer: a cohort prospective study DOI Creative Commons
Qiang Cao, Xia Ye, Xinyan Wu

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 15, 2023

To compare the therapeutic effects and adverse reactions of sterilizing rare earth carbonate combined with concurrent chemoradiotherapy simple in treatment late-stage non-small cell lung cancer (NSCLC), to analyze reasons for differences. A total 817 patients pathologically diagnosed NSCLC from June 1, 2021 December 30, 2022, affiliated hospital Kunming University Science Technology, were selected. They randomly divided into a control group 394 people an experimental 423 people. The was given (cisplatin + etoposide), while simultaneously took low dose sterilized (0.05mg/Kg). χ² test Fisher's used clinical pathological features, objective response rate (ORR), ECOG score, two groups patients, survival analysis progression-free (PFS) groups. Cox regression factors related prognosis. differences features between not statistically significant, all P>0.05. ORR 45.18% (178/394), 89.83% (380/423), significant difference (P=0.001). After treatment, score lower than that group, P<0.001. reaction grading both below level 3 after no treatment-related fatalities occurred. risk pulmonary infection bone marrow suppression group. In compared chemoradiotherapy, combination can significantly improve short-term effect prognosis good safety.

Language: Английский

Citations

15
Development Trends in the Clinical Test of Multiple Myeloma from 2000 to 2023: A Bibliometric Study DOI Creative Commons
Hongcheng Wu,

Haomiao Sun,

Yichen Wang

et al.

Published: Jan. 9, 2025

Objective: This study investigates the development trends and research hotspots in clinical testing for multiple myeloma from 2000 to 2023, using bibliometric techniques. Method: Search relevant literature on of published Web Science Core Collection (WoSCC) use CiteSpace 6.2.R4 software draw a visual knowledge map authors, institutions, national regional cooperation networks, journals, keywords, conduct analysis. Results: The found an upward trend publications over specified period, with significant growth noted 2012 onwards. majority originates United States, contributions institutions like Mayo Clinic MD Anderson Cancer Center. Analysis author collaboration networks indicated relatively low centrality, suggesting minimal among researchers. Bibliometric mapping highlighted several field including therapeutic strategies involving proteasome inhibitors immunomodulatory drugs, role stem cell transplantation, importance achieving monitoring residual disease. Conclusion: is characterized by growing body research, States. Despite increasing volume there need enhanced researchers consolidate findings advance practice.

Language: Английский

Citations

0
Comprehensive review of leonurine: harnessing its therapeutic potential for chronic diseases DOI

Mukesh Kumar Manickasamy,

Uzini Devi Daimary, Anjana Sajeev

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

Citations

0
Knowledge map of programmed cell death in esophageal cancer: a bibliometric analysis DOI Creative Commons

Rulin Li,

Yanchun Yang,

Yang Gao

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 24, 2025

This study aimed to delineate the evolving knowledge structure of programmed cell death in esophageal cancer and identify key thematic trends, influential collaborations, emerging areas for future research. A bibliometric approach was applied 2677 publications retrieved from Web Science Core Collection (2000-2024). Three complementary tools-CiteSpace, VOSviewer, bibliometrix-were employed visualize co-citation networks, detect citation bursts, map collaborative patterns among authors, institutions, countries. Inclusion criteria focused on articles reviews that addressed conjunction with apoptosis, necroptosis, pyroptosis, ferroptosis, autophagy, or related pathways. Publication outputs grew markedly, reflecting a shift early investigations basic apoptotic mechanisms broader explorations ferroptosis. China led publication volume citations, driven by substantial governmental funding large clinical cohorts. The United States Japan also contributed significantly, forming international research networks spanned Asia Europe. Leading particularly Zhengzhou University, demonstrated extensive collaborations. Journals such as Oncology Letters Reports were prominent outlets new findings, while highly cited references highlighted hypoxia, immune checkpoint blockade, gene-editing strategies. Keyword analyses revealed ascendance immuno-oncology, network pharmacology, translational applications targeting multiple regulated Bibliometric evidence underscores rapid expansion multidisciplinary integrates diverse pathways cancer. Continued leveraging advanced genomics immunologic strategies, are poised accelerate breakthroughs enable more personalized, effective therapies.

Language: Английский

Citations

0
Leonurine ameliorates the STAT3 pathway through the upregulation of SHP-1 to retard the growth of hepatocellular carcinoma cells DOI
Young Yun Jung,

Chulwon Kim,

Muthu K. Shanmugam

et al.

Cellular Signalling, Journal Year: 2023, Volume and Issue: 114, P. 111003 - 111003

Published: Dec. 2, 2023

Language: Английский

Citations

5
Review of: "The Application and Pathway Regulation of Traditional Chinese Medicine in Lung Cancer Treatment: An Exploratory Review" DOI Creative Commons
Palmiro Poltronieri

Published: March 8, 2024

Language: Английский

Citations

1
Leonurine: a comprehensive review of pharmacokinetics, pharmacodynamics, and toxicology DOI Creative Commons
Siyu Liu,

Chen Sun,

Hailin Tang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 19, 2024

Leonurine is an alkaloid unique to the

Language: Английский

Citations

1
Advancements in the Detection and Treatment of Rare ALK Fusion Mutations in Hepatocellular Carcinoma: A Case Report and Literature Review DOI Open Access

Yan Qiu

Qeios, Journal Year: 2024, Volume and Issue: unknown

Published: March 4, 2024

This case report and comprehensive literature review highlights the significance of advanced molecular diagnostic techniques, particularly next-generation sequencing (NGS), in identification treatment rare ALK fusion mutations hepatocellular carcinoma (HCC). Through a detailed analysis single patient case, accompanied by existing literature, we underscore challenges therapeutic potential associated with fusions HCC. Our findings demonstrate superior capability NGS, both DNA-based RNA-based, detecting these mutations, leading to targeted approaches inhibitors. The illustrates practical application precision oncology HCC, showcasing significant clinical benefit improved outcomes use inhibitors for types. study not only contributes body knowledge documenting instance HCC but also advocates integration profiling into standard practice enhance personalized strategies care.

Language: Английский

Citations

0