Inflammatory
Bowel
Disease
(IBD),
encompassing
Crohn's
disease
and
ulcerative
colitis,
is
characterized
by
chronic
inflammation
of
the
gastrointestinal
tract,
with
an
increasing
incidence
worldwide.
Recent
advancements
in
cellular
biology
have
identified
ferroptosis,
a
form
programmed
cell
death
driven
iron-dependent
lipid
peroxidation,
as
critical
player
pathology
IBD.
This
article
reviews
current
understanding
ferroptosis
its
distinctive
mechanisms,
including
role
GPx4,
Nrf2-HO-1
pathways,
iron
metabolism
context
It
also
examines
dual
nature
intestinal
health
disease,
contributing
to
both
physiological
functions
pathological
processes
through
oxidative
stress
inflammation.
The
implications
epithelial
death,
barrier
function,
immune
response
are
discussed,
highlighting
potential
novel
therapeutic
target.
Despite
promising
insights,
underscores
need
for
further
research
elucidate
complex
mechanisms
IBD
translate
these
findings
into
effective
strategies.
emerging
evidence
positions
at
crossroads
metabolic,
inflammatory,
offering
unique
perspective
on
interplay
between
nutrition,
genetics,
immunity
disease.
Pediatric
differentiated
thyroid
cancer
(DTC)
presents
unique
challenges
distinct
from
its
adult
counterparts,
including
higher
rates
of
multifocality,
regional
lymph
node
involvement,
and
distant
metastases.
This
article
reviews
the
latest
advancements
controversies
in
surgical
management,
postoperative
care,
long-term
surveillance
pediatric
DTC,
emphasizing
importance
a
tailored
approach
based
on
individual
risk
assessments.
The
evolving
landscape
treatment
strategies
aims
to
balance
imperative
effective
control
with
need
mitigate
adverse
effects
ensure
quality
life.
review
also
highlights
critical
for
ongoing
research
multidisciplinary
collaboration
refine
optimize
management
protocols
this
vulnerable
population.
Lung
cancer
is
one
of
the
cancers
with
highest
mortality
rates.
Non-small
cell
lung
(NSCLC)
accounts
for
85%
cases
and
often
diagnosed
at
an
advanced
stage
a
poor
prognosis.
Due
to
lack
effective
molecular
targets,
current
clinical
cure
rate
low,
recurrence
high.
Recent
studies
have
found
that
active
components
traditional
Chinese
medicine
herbal
formulas
can
inhibit
development
NSCLC
through
multiple
pathways
effectively
reducing
its
metastasis
rates,
improving
treatment
side
effects,
compensating
deficiencies
in
drug
resistance.
Although
treatments
such
as
surgery,
radiotherapy,
targeted
therapy,
immunotherapy
achieved
better
efficacy
treating
cancer,
they
still
problems
complications
severe
adverse
reactions.
In
recent
years,
numerous
basic
confirmed
good
effects
cancer.
Traditional
has
synergistic
regulatory
effect
components,
pathways,
channels.
The
monomeric
complex
mechanisms
action
determine
there
are
issues
unclear
related
prevention
by
medicine.
There
urgent
need
elucidate
intervening
from
perspective
modern
medicine,
levels
biology,
network
pharmacology,
etc.
This
article
systematically
summarizes
research
progress
on
regulation
above-mentioned
signaling
expression
key
protein
molecules
monomers
or
formulas,
aiming
clarify
progression
provide
ideas
theoretical
basis
in-depth
study
application
This
case
report
and
comprehensive
literature
review
highlight
the
significance
of
advanced
molecular
diagnostic
techniques,
particularly
next-generation
sequencing
(NGS),
in
identification
treatment
rare
ALK
fusion
mutations
hepatocellular
carcinoma
(HCC).
Through
a
detailed
analysis
single
patient
case,
accompanied
by
existing
literature,
we
underscore
challenges
therapeutic
potential
associated
with
fusions
HCC.
Our
findings
demonstrate
superior
capability
NGS,
both
DNA-based
RNA-based,
detecting
these
mutations,
leading
to
targeted
approaches
inhibitors.
The
illustrates
practical
application
precision
oncology
HCC,
showcasing
significant
clinical
benefit
improved
outcomes
use
inhibitors
for
types.
study
not
only
contributes
body
knowledge
documenting
instance
HCC
but
also
advocates
integration
profiling
into
standard
practice
enhance
personalized
strategies
care.
Inflammatory
Bowel
Disease
(IBD),
encompassing
Crohn's
disease
and
ulcerative
colitis,
is
characterized
by
chronic
inflammation
of
the
gastrointestinal
tract,
with
an
increasing
incidence
worldwide.
Recent
advancements
in
cellular
biology
have
identified
ferroptosis,
a
form
programmed
cell
death
driven
iron-dependent
lipid
peroxidation,
as
critical
player
pathology
IBD.
This
article
reviews
current
understanding
ferroptosis
its
distinctive
mechanisms,
including
role
GPx4,
Nrf2-HO-1
pathways,
iron
metabolism
context
It
also
examines
dual
nature
intestinal
health
disease,
contributing
to
both
physiological
functions
pathological
processes
through
oxidative
stress
inflammation.
The
implications
epithelial
death,
barrier
function,
immune
response
are
discussed,
highlighting
potential
novel
therapeutic
target.
Despite
promising
insights,
underscores
need
for
further
research
elucidate
complex
mechanisms
IBD
translate
these
findings
into
effective
strategies.
emerging
evidence
positions
at
crossroads
metabolic,
inflammatory,
offering
unique
perspective
on
interplay
between
nutrition,
genetics,
immunity
disease.
