Berberine chloride loaded nano‐PEGylated liposomes attenuates imidacloprid‐induced neurotoxicity by inhibiting NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis DOI Open Access
Walaa Bayoumie El Gazzar, Amina A. Farag, Mohamed Samir

et al.

BioFactors, Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

Abstract Concerns have been expressed about imidacloprid (IMI), one of the most often used pesticides, and its potential neurotoxicity to non‐target organisms. Chronic neuroinflammation is central pathology several neurodegenerative disorders. Hence, exploring molecular mechanism by which IMI would trigger particularly important. This study examined neurotoxic effects oral administration (45 mg/kg/day for 30 days) neuroprotective effect berberine (Ber) chloride loaded nano‐PEGylated liposomes (Ber‐Lip) (10 mg/kg, intravenously every other day using laboratory rat. The histopathological changes, anti‐oxidant oxidative stress markers (GSH, SOD, MDA), proinflammatory cytokines (IL1β TNF‐α), microglia phenotype (CD86 iNOS M1; CD163 M2), canonical pyroptotic pathway (NLRP3, caspase‐1, GSDMD, IL‐18) Alzheimer's disease (Neprilysin beta amyloid [Aβ] deposits) were assessed. Oral resulted in apparent cerebellar alterations, stress, predominance M1 phenotype, significantly upregulated NLRP3, caspase‐1 , GSDMD IL‐18 Aβ deposits decreased Neprilysin expression. Berberine reduced IMI‐induced aberrations measured parameters improved ultrastructure alterations brought on IMI. highlights contribution development displayed Ber‐Lip.

Language: Английский

Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence DOI Creative Commons

Enzo Pereira de Lima,

Lucas Fornari Laurindo,

Vitor Cavallari Strozze Catharin

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 124 - 124

Published: Feb. 13, 2025

Neurodegenerative diseases comprise a group of chronic, usually age-related, disorders characterized by progressive neuronal loss, deformation structure, or loss function, leading to substantially reduced quality life. They remain significant focus scientific and clinical interest due their increasing medical social importance. Most neurodegenerative present intracellular protein aggregation extracellular deposition (plaques), such as α-synuclein in Parkinson's disease amyloid beta (Aβ)/tau aggregates Alzheimer's. Conventional treatments for conditions incur high costs are related the development several adverse effects. In addition, many patients irresponsive them. For these reasons, there is growing tendency find new therapeutic approaches help patients. This review intends investigate some phytocompounds' effects on diseases. These generally increased oxidative stress inflammation, so phytocompounds can prevent treat To achieve our aim provide critical assessment current literature about phytochemicals targeting neurodegeneration, we reviewed reputable databases, including PubMed, EMBASE, COCHRANE, seeking trials that utilized against conditions. A few investigated humans, after screening, 13 were ultimately included following PRISMA guidelines. compounds include polyphenols (flavonoids luteolin quercetin, phenolic acids rosmarinic acid, ferulic caffeic other like resveratrol), alkaloids (such berberine, huperzine A, caffeine), terpenoids ginkgolides limonene). The gathered evidence underscores caffeine, ginkgolides, primarily anti-inflammatory, antioxidant, neuroprotective, counteracting neuroinflammation, oxidation, synaptic dysfunctions, which crucial aspects intervention various conditions, Alzheimer's dementias, depression, neuropsychiatric disorders. summary, they show use improvements cognition, memory, disinhibition, irritability/lability, aberrant behavior, hallucinations, mood

Language: Английский

Citations

5
Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model DOI Creative Commons
Yu‐Zhong Zhang,

Shuai Lv,

Pei-Zheng Huang

et al.

npj Science of Food, Journal Year: 2025, Volume and Issue: 9(1)

Published: Feb. 4, 2025

Research indicated that berberine (BBR) plays a protective role in modulating Alzheimer's disease (AD). This study aimed to explore the target genes of BBR associated with AD therapy using network pharmacology study. Through analysis, two main potential genes, β-amyloid precursor protein (APP) and peroxisome proliferator-activated receptor gamma (PPARG), for were screened out. Further experiments demonstrated BV2 C8-D1A treated decreased mRNA expression APP presenilin 1 while PPARG was increased reduction NF-κB pathway. A similar result shown vivo. study, this supported played mice model via blocking processing amyloid plaque formation. It also promotes blockage pathway-mediated inflammatory response neuroinflammation.

Language: Английский

Citations

0
Extracellular vesicle-packed microRNAs profiling in Alzheimer’s disease: The molecular intermediary between pathology and diagnosis DOI

S. H. Arif,

Talal Jamil Qazi, Zhenzhen Quan

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102614 - 102614

Published: Dec. 1, 2024

Language: Английский

Citations

2
Berberine chloride loaded nano‐PEGylated liposomes attenuates imidacloprid‐induced neurotoxicity by inhibiting NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis DOI Open Access
Walaa Bayoumie El Gazzar, Amina A. Farag, Mohamed Samir

et al.

BioFactors, Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

Abstract Concerns have been expressed about imidacloprid (IMI), one of the most often used pesticides, and its potential neurotoxicity to non‐target organisms. Chronic neuroinflammation is central pathology several neurodegenerative disorders. Hence, exploring molecular mechanism by which IMI would trigger particularly important. This study examined neurotoxic effects oral administration (45 mg/kg/day for 30 days) neuroprotective effect berberine (Ber) chloride loaded nano‐PEGylated liposomes (Ber‐Lip) (10 mg/kg, intravenously every other day using laboratory rat. The histopathological changes, anti‐oxidant oxidative stress markers (GSH, SOD, MDA), proinflammatory cytokines (IL1β TNF‐α), microglia phenotype (CD86 iNOS M1; CD163 M2), canonical pyroptotic pathway (NLRP3, caspase‐1, GSDMD, IL‐18) Alzheimer's disease (Neprilysin beta amyloid [Aβ] deposits) were assessed. Oral resulted in apparent cerebellar alterations, stress, predominance M1 phenotype, significantly upregulated NLRP3, caspase‐1 , GSDMD IL‐18 Aβ deposits decreased Neprilysin expression. Berberine reduced IMI‐induced aberrations measured parameters improved ultrastructure alterations brought on IMI. highlights contribution development displayed Ber‐Lip.

Language: Английский

Citations

0