Application of Network Pharmacology in the Treatment of Neurodegenerative Diseases with Traditional Chinese Medicine

Planta Medica, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

In recent years, the incidence of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s Huntington’s and amyotrophic lateral sclerosis, has shown a steadily rising trend, which posed major challenge to global public health. Traditional Chinese Medicine (TCM), with its multi-component multi-target characteristics, offers promising approach for treatment diseases. However, it is difficult comprehensively elucidate complex mechanisms underlying TCM formulations. As an emerging systems biology approach, network pharmacology provided crucial tool uncovering through high-throughput technologies, molecular docking, analysis. This paper reviews advancements in application treating diseases TCM, analyzes current status relevant databases technological methods, discusses limitations research, proposes future directions promote modernization development precision medicine. Keywords: Neurodegenerative Medicine, Network pharmacology, Therapeutic targets

Language: Английский

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Molecular mechanism of Gancao Xiexin Decoction regulating EMT and suppressing Hepatic Metastasis of Gastric Cancer via the TGF-β1/SMAD Pathway

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119430 - 119430

Published: Feb. 1, 2025

Language: Английский

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QingReDu capsule ameliorates psoriasis vulgaris by regulating EZH2/NF-κB signaling pathway

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: March 3, 2025

Language: Английский

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Computer-Aided Drug Design in Research on Chinese Materia Medica: Methods, Applications, Advantages, and Challenges

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 315 - 315

Published: March 1, 2025

Chinese materia medica (CMM) refers to the medicinal substances used in traditional medicine. In recent years, CMM has become globally prevalent, and scientific research on increasingly garnered attention. Computer-aided drug design (CADD) been employed Western medicine for many contributing significantly its progress. However, role of CADD not systematically reviewed. This review briefly introduces methods from perspectives computational chemistry (including quantum chemistry, molecular mechanics, mechanics/molecular mechanics) informatics cheminformatics, bioinformatics, data mining). Then, it provides an exhaustive discussion applications these through rich cases. Finally, outlines advantages challenges research. conclusion, despite current challenges, still offers unique over experiments. With development industry computer science, especially driven by artificial intelligence, is poised play pivotal advancing

Language: Английский

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Digital intelligence technology: new quality productivity for precision traditional Chinese medicine

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 8, 2025

Traditional Chinese medicine is a complex medical system characterized by multiple metabolites, targets, and pathways, known for its low drug resistance significant efficacy. However, challenges persist within medicine, including difficulties in assessing the quality of Botanical drugs, reliance on experiential knowledge disease diagnosis treatment, lack clarity regarding pharmacological mechanisms medicine. The advancement digital intelligence technology driving shift towards precision model. This transition propels into an era precision, intelligence, digitalization. paper introduces standard technologies explores application control evaluation studies research status assisting diagnosis, treatment prevention diseases, further promotes development field

Language: Английский

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TCMKD: From ancient wisdom to modern insights-A comprehensive platform for traditional Chinese medicine knowledge discovery

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101297 - 101297

Published: April 1, 2025

Language: Английский

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Alleviating Effects of Ethanol Extract from Acremonium terricola Culture on Patulin Toxicity

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 509 - 509

Published: April 24, 2025

Exposure to patulin (PAT) poses a significant health risk animals, emphasizing the need for natural, safe substances mitigate toxicity. Acremonium terricola culture (ATC), fungal fermentation-derived feed additive, is known its antioxidant properties, yet potential alleviate mycotoxin-induced toxicity remains largely uninvestigated. In this study, ethanol extracts from ATC (EEAT) were prepared with total phenolic content of 67.9 mg GAE/g and flavonoid 32.7 RE/g. Ultra-high performance liquid chromatography coupled tandem mass spectrometry (UPLC-ESI-MS/MS) analysis was employed investigate bioactive components in EEAT. PAT-exposed Caenorhabditis elegans models, EEAT treatment significantly enhanced locomotory capacity elevated enzyme activities by 63.1% (SOD) 90.1% (GSH-ST), respectively. Molecular docking revealed that key active compounds EEAT, such as coumarin, succinic acid, trigonelline, exhibited effective binding affinities targets SIR-2.1 DAF-2. Notably, coumarin trigonelline most alleviating PAT toxicity, evidenced rescued locomotor rates oxidative impairment C. elegans. Our findings not only elucidate molecular basis EEAT-mediated mitigation but also establish A. sustainable antioxidant.

Language: Английский

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Mechanisms of Zanthoxyli Pericarpium-Zingiberis Rhizoma in the Treatment of Gastric Cancer Based on Network Pharmacology and Experimental Validation

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 4537 - 4566

Published: May 1, 2025

Malignant tumors, as a major challenge in global public health, have posed significant threat to human life and health. Although traditional chemotherapy can inhibit tumor growth, it is often associated with serious adverse effects tolerance. Against this background, Chinese medicine therapies gradually gained wide recognition, they play an important role the treatment of gastric cancer (GC). As core combination prescription "Dajianzhong Tang", medicinal pair Zanthoxyli Pericarpium Zingiberis Rhizoma (ZP-ZR) has shown unique advantages treatment. To explore mechanism action ZP-ZR GC using network pharmacology, bioinformatics analysis vitro experimental validation, provide theoretical basis for subsequent studies. Subsequently, on proliferative ability HGC-27 AGS cell lines were verified by CCK-8, apoptosis, cycle colony formation assays. The metastatic cells evaluated Wound healing, transwell invasion migration In addition, we expression Hub genes, pathway proteins mRNAs Western blot qRT-PCR. mainly regulated EGFR, PTGS2, MMP9, CXCL8, BCL2L1, CDK6, KIT target genes PI3K/Akt cancer. inhibited proliferation, induced blocked cycle, lines. affected PI3K-Akt-related decreased mRNA genes. treats through PI3K-Akt pathway.The present study provides new idea further investigation GC.

Language: Английский

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Pharmacodynamics of Sishen decoction in relieving rheumatoid arthritis: Chemical composition, regulatory pathway and online prediction simulation

Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e37257 - e37257

Published: Aug. 30, 2024

Language: Английский

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Analysis of the mechanism of Zangjiangzhi capsule in the treatment of hyperlipidemia based on its ingredients identified by UHPLC-Q-Exactive Orbitrap MS

Journal of Traditional Chinese Medical Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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