Lung
cancer
is
one
of
the
cancers
with
highest
mortality
rates.
Non-small
cell
lung
(NSCLC)
accounts
for
85%
cases
and
often
diagnosed
at
an
advanced
stage
a
poor
prognosis.
Due
to
lack
effective
molecular
targets,
current
clinical
cure
rate
low,
recurrence
high.
Recent
studies
have
found
that
active
components
traditional
Chinese
medicine
herbal
formulas
can
inhibit
development
NSCLC
through
multiple
pathways
effectively
reducing
its
metastasis
rates,
improving
treatment
side
effects,
compensating
deficiencies
in
drug
resistance.
Although
treatments
such
as
surgery,
radiotherapy,
targeted
therapy,
immunotherapy
achieved
better
efficacy
treating
cancer,
they
still
problems
complications
severe
adverse
reactions.
In
recent
years,
numerous
basic
confirmed
good
effects
cancer.
Traditional
has
synergistic
regulatory
effect
components,
pathways,
channels.
The
monomeric
complex
mechanisms
action
determine
there
are
issues
unclear
related
prevention
by
medicine.
There
urgent
need
elucidate
intervening
from
perspective
modern
medicine,
levels
biology,
network
pharmacology,
etc.
This
article
systematically
summarizes
research
progress
on
regulation
above-mentioned
signaling
expression
key
protein
molecules
monomers
or
formulas,
aiming
clarify
progression
provide
ideas
theoretical
basis
in-depth
study
application
Journal of Personalized Medicine,
Journal Year:
2024,
Volume and Issue:
14(8), P. 831 - 831
Published: Aug. 6, 2024
Chronic
Lymphocytic
Leukemia
(CLL)
is
the
most
common
B-cell
malignancy
in
Western
world,
characterized
by
frequent
relapses
despite
temporary
remissions.
Our
study
integrated
publicly
available
proteomic,
transcriptomic,
and
patient
survival
datasets
to
identify
key
differences
between
healthy
CLL
samples.
We
exposed
approximately
1000
proteins
that
differentiate
from
cancerous
cells,
with
608
upregulated
415
downregulated
cases.
Notable
include
YEATS2
(an
epigenetic
regulator),
PIGR
(Polymeric
immunoglobulin
receptor),
SNRPA
(a
splicing
factor),
which
may
serve
as
prognostic
biomarkers
for
this
disease.
Key
pathways
implicated
progression
involve
RNA
processing,
stress
resistance,
immune
response
deficits.
Furthermore,
we
identified
three
existing
drugs-Bosutinib,
Vorinostat,
Panobinostat-for
potential
further
investigation
drug
repurposing
CLL.
also
found
limited
correlation
transcriptomic
proteomic
data,
emphasizing
importance
of
proteomics
understanding
gene
expression
regulation
mechanisms.
This
generally
known
disparity
highlights
once
again
mRNA
levels
do
not
accurately
predict
protein
abundance
due
many
regulatory
factors,
such
degradation,
post-transcriptional
modifications,
differing
rates
translation.
These
results
demonstrate
value
integrating
omics
data
uncover
deregulated
cancer
suggest
new
therapeutic
avenues
Pediatric
differentiated
thyroid
cancer
(DTC)
presents
unique
challenges
distinct
from
its
adult
counterparts,
including
higher
rates
of
multifocality,
regional
lymph
node
involvement,
and
distant
metastases.
This
article
reviews
the
latest
advancements
controversies
in
surgical
management,
postoperative
care,
long-term
surveillance
pediatric
DTC,
emphasizing
importance
a
tailored
approach
based
on
individual
risk
assessments.
The
evolving
landscape
treatment
strategies
aims
to
balance
imperative
effective
control
with
need
mitigate
adverse
effects
ensure
quality
life.
review
also
highlights
critical
for
ongoing
research
multidisciplinary
collaboration
refine
optimize
management
protocols
this
vulnerable
population.
Lung
cancer
is
one
of
the
cancers
with
highest
mortality
rates.
Non-small
cell
lung
(NSCLC)
accounts
for
85%
cases
and
often
diagnosed
at
an
advanced
stage
a
poor
prognosis.
Due
to
lack
effective
molecular
targets,
current
clinical
cure
rate
low,
recurrence
high.
Recent
studies
have
found
that
active
components
traditional
Chinese
medicine
herbal
formulas
can
inhibit
development
NSCLC
through
multiple
pathways
effectively
reducing
its
metastasis
rates,
improving
treatment
side
effects,
compensating
deficiencies
in
drug
resistance.
Although
treatments
such
as
surgery,
radiotherapy,
targeted
therapy,
immunotherapy
achieved
better
efficacy
treating
cancer,
they
still
problems
complications
severe
adverse
reactions.
In
recent
years,
numerous
basic
confirmed
good
effects
cancer.
Traditional
has
synergistic
regulatory
effect
components,
pathways,
channels.
The
monomeric
complex
mechanisms
action
determine
there
are
issues
unclear
related
prevention
by
medicine.
There
urgent
need
elucidate
intervening
from
perspective
modern
medicine,
levels
biology,
network
pharmacology,
etc.
This
article
systematically
summarizes
research
progress
on
regulation
above-mentioned
signaling
expression
key
protein
molecules
monomers
or
formulas,
aiming
clarify
progression
provide
ideas
theoretical
basis
in-depth
study
application
