Precision Nanomedicine,
Journal Year:
2024,
Volume and Issue:
7(4)
Published: Dec. 11, 2024
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Topical
and
transdermal
drug
delivery
are
alternative
routes
for
medications
facing
challenges
like
solubility,
stability,
first-pass
metabolism.
However,
conventional
immediate-release
dosage
forms
delivered
topically
have
drawbacks,
including
poor
penetration
high
side
ef-fects.
Controlled-release
nanoparticles
offer
a
promising
solution,
improving
permeation
providing
controlled
release.
This
review
examines
recent
advances,
challenges,
prospects
of
controlled-release
topical
delivery.
Various
types
nanoparticles,
lipid
nanoemulsions,
nanoemulgels,
cubosome
liposomes,
poly-meric
solid-lipid
lipid-polymer
hybrid
nanostructured
carriers,
carbon
nanotubes,
nanocomposites,
protein
been
explored
their
ability
to
encapsulate
drugs,
prolong
release,
enhance
skin
as
well
improve
therapeutic
outcomes.
Studies
demonstrated
the
effectiveness
these
in
sustained
wide
range
poorly
soluble,
low
degree
penetration,
drugs
with
bioavailability
biological
products.
Despite
potential
benefits,
such
scalability,
reproducibility,
safety
concerns
remain.
Future
research
should
ad-dress
explore
novel
strategies
efficacy
by
converging
microneedles
3D
nanoparticles.
Ultimately,
revolutionize
dermatological
delivery,
leading
improved
outcomes
patient
care.
Marine Drugs,
Journal Year:
2024,
Volume and Issue:
22(10), P. 457 - 457
Published: Oct. 5, 2024
This
literature
review
investigated
the
anti-inflammatory
properties
of
brown
algae,
emphasizing
their
potential
for
dermatological
applications.
Due
to
limitations
and
side
effects
associated
with
corticosteroids
immunomodulators,
interest
has
been
growing
in
harnessing
therapeutic
qualities
from
natural
products
as
alternatives
traditional
treatments
skin
inflammation.
explored
bioactive
compounds
specifically
looking
into
two
compounds,
namely,
fucoidans
phlorotannins,
which
are
widely
known
exhibit
properties.
synthesized
findings
various
studies,
highlighting
how
these
can
mitigate
inflammation
by
mechanisms
such
reducing
oxidative
stress,
inhibiting
protein
denaturation,
modulating
immune
responses,
targeting
inflammatory
pathways,
particularly
conditions
like
atopic
dermatitis.
The
revealed
species-specific
variations
influenced
molecular
weight
sulphate
content.
Challenges
related
permeability
were
addressed,
nanoformulations
penetration
enhancers
improve
delivery.
While
vivo
results
using
animal
models
provided
positive
results,
further
clinical
trials
necessary
confirm
outcomes
humans.
concludes
that
algae
hold
substantial
promise
developing
new
encourages
research
optimize
extraction
methods,
understand
mechanisms,
address
practical
challenges
sustainability
regulatory
compliance.
contributes
body
evidence
supporting
integration
marine-derived
applications
diseases.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(1), P. 48 - 48
Published: Jan. 2, 2025
Background/Objectives:
The
demand
for
a
safe
compound
hyperpigmentation
is
continuously
increasing.
Bioactive
compounds
such
as
thymoquinone
(TQ)
and
ascorbic
acid
(AA)
induce
inhibition
of
melanogenesis
with
high
safety
profile.
aim
this
study
was
to
design
evaluate
spanlastics
gel
loaded
bioactive
agents,
TQ
AA,
the
management
hyperpigmentation.
Methods:
Several
formulations
were
successfully
fabricated
characterized
in
terms
morphology,
vesicle
size,
zeta
potential,
release.
Results:
optimized
TQ-loaded
spanlastic
formulation
showed
an
average
size
223.40
±
3.50
nm,
133.00
2.80
nm
AA-loaded
formulation.
highest
entrapment
efficiency
(EE%)
97.18
2.02%
93.08
1.95%,
respectively.
Additionally,
edge
activator
concentration
had
significant
effect
(p
<
0.05)
on
EE%;
it
found
that
by
increasing
amount
EA,
EE%
increases.
Following
that,
optimal
fomulation
AA
incorporated
into
explored
appearance,
pH,
spreadability,
stability,
rheology,
vitro
release,
ex
vivo
permeation
study,
MTT
cytotoxicity.
formulated
(R-1)
has
pH
5.53.
R-1
significantly
more
spreadable
than
control
gel,
exhibited
shear
thinning
behavior.
Most
importantly,
skin
deposition
studies
confirmed
superior
from
gels.
results
indicated
tyrosinase
primarily
due
TQ.
When
comparing
alone
TQ-AA
combination,
ranged
18.35
42.73%
24.28
42.53%,
Both
combination
concentration-dependent
tyrosinase.
Conclusions:
Spanlastic
might
represent
promising
carrier
dermal
delivery
conditions.
Expert Opinion on Drug Delivery,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 8, 2025
Iontophoresis
has
been
extensively
studied
for
topical
and
transdermal
drug
delivery
to
stimulate
the
absorption
of
molecules
that
would
hardly
pass
through
outermost
layer
skin
passively.
Recent
research
focused
on
its
combination
with
nanoparticle-based
systems
or
microneedles
expand
therapeutic
applications.
This
review
explores
fundamental
principles
iontophoresis,
focusing
key
factors
influencing
transport
mechanisms,
provides
a
discussion
field's
current
state.
A
comprehensive
analysis
articles
published
available
online
in
2024
was
conducted,
categorizing
studies
by
their
application
areas,
systems,
iontophoretic
conditions,
experimental
limitations.
The
findings
reveal
recent
focus
wound
healing
repair,
advancements
treating
inflammation,
pain,
cancer.
Market
translation
requires
standardized
protocols,
particularly
parameters
preclinical
models,
along
development
cost-effective
commercial
devices.
Additionally,
while
cutaneous
have
increasingly
benefited
from
machine
learning
approaches,
iontophoresis
remains
underexplored.
With
growing
interest
associating
Internet
Things,
such
an
integration,
if
combined
AI
tools,
could
offer
promising
opportunities
personalized,
real-time
treatments
modern
dermatology,
systems.
