Bile acid metabolism in health and ageing-related diseases

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 225, P. 116313 - 116313

Published: May 22, 2024

Language: Английский

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Targeting Nrf2/HO-1 and NF-κB/TNF-α signaling pathways with empagliflozin protects against atrial fibrillation-induced acute kidney injury in rats

Toxicology, Journal Year: 2024, Volume and Issue: 506, P. 153879 - 153879

Published: July 4, 2024

Language: Английский

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BK Polyomavirus and acute kidney injury in transplant recipients: signaling pathways and molecular mechanisms

Virology Journal, Journal Year: 2025, Volume and Issue: 22(1)

Published: Jan. 4, 2025

Acute kidney injury (AKI) is a condition that can result in changes both urine production and creatinine levels the bloodstream, complicating treatment process worsening outcomes for many hospitalized patients. BK polyomavirus (BKPyV), member of Polyomaviridae family, prevalent population remains latent body. It reactivate individuals with compromised immune system, particularly post-kidney transplant, activate various transcription factors mediators. Although reactivation often asymptomatic, it present as AKI, which risk factor early loss transplanted organ. The response to BKPyV crucial controlling virus safeguarding organs from damage during infection. Understanding pathways may offer novel opportunities effectively treating BKPyV-associated complications. This review seeks elucidate potential mechanisms by lead AKI analyzing signaling pathways, well identification molecular utilize induce AKI.

Language: Английский

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Exploring disulfiram mechanisms in renal fibrosis: insights from biological data and computational approaches

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 18, 2025

Disulfiram (DSF) is an anti-alcoholic drug that has been reported to inhibit the epithelial-to-mesenchymal transition and crosslinking during fibrosis, pyroptosis, inflammatory NF-κB Nrf-2 signaling pathways. However, there insufficient evidence support mechanisms of DSF in preventing renal fibrosis (RF). Therefore, current study aimed elucidate DSF-modulated targets pathways fibrosis. The common proteins between RF were screened for protein-protein interaction, pathway enrichment, cluster, gene ontology analysis. Molecular docking was executed core genes using AutoDock Vina through POAP pipeline. dynamics (MD) simulation (100 ns) performed infer protein-ligand stability, conformational changes analyzed by free energy landscape (FEL). A total 78 found be RF, which NFKB, PIK3CA/R1, MTOR, PTGS2, MMP9 genes. PI3K-Akt followed JAK-STAT, TNF, Ras, ErbB, p53, phospholipase D, mTOR, IL-17, NF-κB, AMPK, VEGF, MAPK modulated RF. showed a direct binding affinity with active site residues genes, except all other complexes, including standard, stable 100 ns MD minimal root mean squared deviation residual fluctuations higher compactness broad changes. protects against this paves way experimental investigation repurpose treating

Language: Английский

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Significance of FXR agonists in MASLD treatment: a deep dive into lipid alteration by analytical techniques

Published: March 25, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is rapidly emerging as a global health crisis, affecting over 30% of the population and demanding urgent attention. This redefined condition, previously known non-alcoholic fatty (NAFLD), reflects deeper understanding intricate interplay between metabolic dysfunction health. At heart MASLD lies troubling accumulation triglycerides (TGs) in hepatocytes, which precipitates insulin resistance oxidative stress, ultimately leading to more severe forms like steatohepatitis (MASH). Excitingly, recent research has spotlighted farnesoid X receptor (FXR) groundbreaking therapeutic target. FXR not only regulates lipid metabolism but also combats inflammation resistance, making it potential game-changer fight against MASLD. With one FDA-approved drug, resmetirom, currently available, exploration agonists opens new avenues for innovative treatments that could revolutionize patient care. By harnessing power restore balance integrating advanced strategies lipidomics acid profiling, we stand on brink transforming how approach its associated complications, paving way healthier future. review delves into promising role combating implications related disorders, emphasizing urgency detect manage this burgeoning epidemic.

Language: Английский

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Ganoderma lucidum and Robinia pseudoacacia Flower Extract Complex Alleviates Kidney Inflammation and Fibrosis by Modulating Oxidative Stress

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 409 - 409

Published: March 28, 2025

Chronic kidney disease (CKD) is characterized by functional and structural abnormalities, with its progression strongly influenced oxidative stress inflammatory responses, ultimately leading to renal fibrosis. This study aimed investigate the effects of a Ganoderma lucidum Robinia pseudoacacia flower extract complex (NEPROBIN) through in vitro vivo experiments. In experiments NRK52E tubular epithelial cells demonstrated that NEPROBIN significantly alleviates H2O2-induced suppresses lipopolysaccharide (LPS)-induced activation mitogen-activated protein kinase (MAPK) nuclear factor kappa-light-chain-enhancer activated B (NF-κB) signaling pathways. Additionally, reduced LPS-induced NF-κB transcriptional activity downregulated expression cytokines chemokines these cells. We further investigated vivo. Kidney damage was induced mice using 0.25% adenine diet (AD), were orally treated at doses 100, 200, 400 mg/kg/day for two weeks. treatment AD-induced elevations blood urea, serum creatinine, urinary β2-microglobulin levels. Markers notably lower kidneys NEPROBIN-treated mice. Furthermore, effectively mitigated response kidneys, marked reduction cytokine chemokine expression. decrease inflammation associated significant tubulointerstitial Overall, alleviated fibrosis directly targeting inflammation, highlighting potential as therapeutic agent CKD.

Language: Английский

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Apitherapy for drug-induced kidney disease: a narrative review on its mechanisms

Journal of Complementary and Integrative Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Abstract Objectives The use of medications for the treatment various diseases often results in kidney damage. Apitherapy is a natural therapeutic tool with potential utility this purpose. This narrative review analyzes and summarizes scientific evidence on apitherapy drug-induced disease. Content recent advances disease explores, based available evidence, how can modify these mechanisms be utilized prevention treatment. Summary (the complementary integrative beehive products) potentially useful system diseases. examines preclinical clinical regarding its Outlook has effects pathophysiological disease, including oxidative stress, inflammation, decreased renal blood flow, glomerular damage, increased membrane permeability, activity renin-angiotensin-aldosterone axis, mitochondrial dysfunction, apoptosis. Further studies humans are needed to evaluate efficacy setting, but promising.

Language: Английский

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HDAC6 promotes inflammation in lupus nephritis mice by regulating transcription factors MAFF and KLF5 in renal fibrosis

Renal Failure, Journal Year: 2024, Volume and Issue: 46(2)

Published: Oct. 16, 2024

This study explored the effect and mechanism of MAFF HDAC6 on renal fibrosis inflammation in lupus nephritis (LN).

Language: Английский

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JMJD3 activation contributes to renal protection and regeneration following acute kidney injury in mice

The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(7)

Published: March 29, 2024

Abstract We have recently demonstrated that Jumonji domain‐containing protein D3 (JMJD3), a histone demethylase of H3 on lysine 27 (H3K27me3), is protective against renal fibrosis, but its role in acute kidney injury (AKI) remains unexplored. Here, we report JMJD3 activity required for protection and regeneration murine models AKI induced by ischemia/reperfusion (I/R) folic acid (FA). Injury to the upregulated expression H3K27me3, which was coincident with dysfunction, tubular cell injury/apoptosis, proliferation. Blocking GSKJ4 led worsening dysfunction pathological changes aggravating epithelial apoptosis both AKI. inhibition also reduced proliferation suppressed cyclin E phosphorylation CDK2, increased p21 injured kidney. Furthermore, inactivation enhanced I/R‐ or FA‐induced TGF‐β1, vimentin, Snail, Smad3, STAT3, NF‐κB, infiltration F4/80 (+) macrophages. Finally, treatment caused further downregulation Klotho, BMP‐7, Smad7, E‐cadherin, all are associated anti‐fibrotic effects. Therefore, these data provide strong evidence activation contributes survival after

Language: Английский

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Renal Fibrosis: SIRT1 Still of Value

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 1942 - 1942

Published: Aug. 23, 2024

Chronic kidney disease (CKD) is a major global health concern. Renal fibrosis, prevalent outcome regardless of the initial cause, ultimately leads to end-stage renal disease. Glomerulosclerosis and interstitial fibrosis are primary pathological features. Preventing slowing considered effective strategies for delaying CKD progression. However, treatments lacking. Sirtuin 1 (SIRT1), nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase belonging class III histone deacetylases, implicated in physiological regulation protection susceptible diverse array influences, as demonstrated previous studies. Interestingly, controversial conclusions have emerged research has progressed. This review provides comprehensive summary current understanding advancements field; specifically, biological roles mechanisms SIRT1 regulating These include aspects such lipid metabolism, epithelial-mesenchymal transition, oxidative stress, aging, inflammation, autophagy. manuscript explores potential therapeutic target offers new perspectives on treatment approaches prognostic assessments.

Language: Английский

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