Baicalein, a natural flavonoid in gastrointestinal cancers treatment: recent trends and future perspectives DOI
Añil Sharma, Deeksha Pal,

Anita Rani Gill

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 42(1)

Published: Dec. 24, 2024

Language: Английский

Green lignocellulose-nanofibers-based molecular imprinting membranes for baicalin selective adsorption DOI
Long Li, Song Hu, Feng Shao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140439 - 140439

Published: Jan. 1, 2025

Language: Английский

Citations

2
Baicalin and Baicalein Enhance Cytotoxicity, Proapoptotic Activity, and Genotoxicity of Doxorubicin and Docetaxel in MCF-7 Breast Cancer Cells DOI Creative Commons
Joanna Bernasińska, Paweł Hikisz, Anna Pieniążek

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(11), P. 2503 - 2503

Published: May 25, 2024

Breast cancer is a major health concern and the leading cause of death among women worldwide. Standard treatment often involves surgery, radiotherapy, chemotherapy, but these come with side effects limitations. Researchers are exploring natural compounds like baicalin baicalein, derived from Scutellaria baicalensis plant, as potential complementary therapies. This study investigated baicalein on cytotoxic, proapoptotic, genotoxic activity doxorubicin docetaxel, commonly used chemotherapeutic drugs for breast cancer. The analysis included cells (MCF-7) human endothelial (HUVEC-ST), to assess healthy tissues. We have found that demonstrated cytotoxicity towards both cell lines, more potent observed in baicalein. Both flavonoids, (167 µmol/L) (95 µmol/L), synergistically enhanced docetaxel cells. In comparison, their were mixed depended concentration time. results suggest might be promising agents improve efficacy anticancer activity. However, further research needed validate safety clinical trials.

Language: Английский

Citations

4
Baicalein prevents pregnancy loss by maintaining regulatory T cell activation through inhibition of the TLR4/NF-κB signaling pathway DOI Creative Commons
Caiqun Huang,

En-Hui Cheng,

Jinping Ni

et al.

Placenta, Journal Year: 2025, Volume and Issue: 165, P. 120 - 126

Published: April 15, 2025

Language: Английский

Citations

0
Synergistic passivation of black phosphorene with both silver nanoparticles and rice husk biochar for enhanced electrochemical detection of baicalin DOI
Xiangrong Zeng,

Zhongshu Duan,

Yifu Zhu

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113898 - 113898

Published: May 1, 2025

Language: Английский

Citations

0
Flavonoids as Bioenhancers: A Critical Review on Their Potential to Improve Drug Delivery and Therapeutic Outcomes DOI
Rakesh Mishra,

Jitendra Hiwarkar,

Abhishek Nikam

et al.

Pharmacological Research - Natural Products, Journal Year: 2025, Volume and Issue: unknown, P. 100251 - 100251

Published: May 1, 2025

Language: Английский

Citations

0
The role of inflammation in colorectal Cancer and the preventive potential of natural compounds DOI
Nasreddine El Omari, Meriem El Fessikh, Sara Aboulaghras

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 129, P. 106857 - 106857

Published: May 15, 2025

Language: Английский

Citations

0
Preliminary investigation on the mechanism of baicalein regulating the effects of Nischarin on invasion and apoptosis of human breast cancer cells MCF-7 through Wnt3α/β-catenin pathway DOI

Gaojian He,

Xuemei Huang,

Yun Dong

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113262 - 113262

Published: Sept. 30, 2024

Language: Английский

Citations

2
Research Progress of Scutellaria baicalensis in the Treatment of Gastrointestinal Cancer DOI Creative Commons

Lankang Wang,

Baoyi Ni,

Jia Wang

et al.

Integrative Cancer Therapies, Journal Year: 2024, Volume and Issue: 23

Published: Jan. 1, 2024

Gastrointestinal (GI) cancer stands as one of the most prevalent forms globally, presenting a substantial medical and economic burden on treatment. Despite advancements in therapies, it continues to exhibit second highest mortality rate, primarily attributed drug resistance post-treatment side effects. There is an urgent need for novel therapeutic approaches tackle this persistent challenge. Scutellaria baicalensis, widely used Traditional Chinese Medicine (TCM), holds profound pharmaceutical legacy. Modern pharmacological studies have unveiled its anticancer, antioxidant, immune-enhancing properties. S. baicalensis contains hundreds active ingredients, with flavonoids, polysaccharides, phenylethanoid glycosides, terpenoids, sterols being principal components. These constituents contribute treatment GI by inducing apoptosis tumor cells, arresting cell cycle, inhibiting proliferation metastasis, regulating microenvironment, modulating epigenetics, reversing resistance. Furthermore, utilization modern delivery technologies can enhance bioavailability efficacy TCM. The characterized multi-component, multi-target, multi-pathway advantages, has broad prospect becoming clinical adjuvant or even main therapy cancer.

Language: Английский

Citations

1
Preparation and Characterization of 3D Printed dECM/GelMA/NC/SA Tissue Engineered Hybrid Scaffold DOI
Shu Yan,

Jinmeng Ye,

Yuanyuan Tang

et al.

Mechanisms and machine science, Journal Year: 2024, Volume and Issue: unknown, P. 459 - 468

Published: Jan. 1, 2024

Language: Английский

Citations

0
Baicalein, a natural flavonoid in gastrointestinal cancers treatment: recent trends and future perspectives DOI
Añil Sharma, Deeksha Pal,

Anita Rani Gill

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 42(1)

Published: Dec. 24, 2024

Language: Английский

Citations

0