Fibroblast Diversity and Epigenetic Regulation in Cardiac Fibrosis
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 6004 - 6004
Published: May 30, 2024
Cardiac
fibrosis,
a
process
characterized
by
excessive
extracellular
matrix
(ECM)
deposition,
is
common
pathological
consequence
of
many
cardiovascular
diseases
(CVDs)
normally
resulting
in
organ
failure
and
death.
fibroblasts
(CFs)
play
an
essential
role
deleterious
cardiac
remodeling
dysfunction.
In
response
to
injury,
quiescent
CFs
become
activated
adopt
collagen-secreting
phenotype
highly
contributing
fibrosis.
recent
years,
studies
have
been
focused
on
the
exploration
molecular
cellular
mechanisms
implicated
activation
CFs,
which
allow
development
novel
therapeutic
approaches
for
treatment
Transcriptomic
analyses
using
single-cell
RNA
sequencing
(RNA-seq)
helped
elucidate
high
diversity
complex
intercellular
communication
networks
that
establish
mammalian
heart.
Furthermore,
significant
body
work
supports
critical
epigenetic
regulation
expression
genes
involved
pathogenesis
The
study
mechanisms,
including
DNA
methylation,
histone
modification,
chromatin
remodeling,
has
provided
more
insights
into
CF
fibrotic
processes.
Targeting
regulators,
especially
methyltransferases
(DNMT),
acetylases
(HAT),
or
deacetylases
(HDAC),
emerged
as
promising
approach
anti-fibrotic
therapies.
This
review
focuses
transcriptomic
advances
regarding
modulate
their
possible
clinical
applications
Language: Английский
The Influence of Metabolic Risk Factors on the Inflammatory Response Triggered by Myocardial Infarction: Bridging Pathophysiology to Treatment
Cells,
Journal Year:
2024,
Volume and Issue:
13(13), P. 1125 - 1125
Published: June 29, 2024
Myocardial
infarction
(MI)
sets
off
a
complex
inflammatory
cascade
that
is
crucial
for
effective
cardiac
healing
and
scar
formation.
Yet,
if
this
response
becomes
excessive
or
uncontrolled,
it
can
lead
to
cardiovascular
complications.
This
review
aims
provide
comprehensive
overview
of
the
tightly
regulated
local
triggered
in
early
post-MI
phase
involving
cardiomyocytes,
(myo)fibroblasts,
endothelial
cells,
infiltrating
immune
cells.
Next,
we
explore
how
bone
marrow
extramedullary
hematopoiesis
(such
as
spleen)
contribute
sustaining
cell
supply
at
level.
Lastly,
discuss
recent
findings
on
metabolic
risk
factors,
including
hypercholesterolemia,
hypertriglyceridemia,
diabetes,
hypertension,
disrupt
immunological
potential
modulatory
effects
lifestyle
habits
pharmacological
interventions.
Understanding
different
factors
influence
by
MI
unraveling
underlying
molecular
cellular
mechanisms
may
pave
way
developing
personalized
therapeutic
approaches
based
patient’s
profile.
Similarly,
delving
deeper
into
impact
modifications
crucial.
These
insights
enable
adoption
more
strategies
manage
inflammation
improve
health
outcomes
holistic
manner.
Language: Английский