Traditional Chinese medicine in lung cancer treatment

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 26, 2025

Lung cancer remains a major global health challenge and one of the leading causes cancer-related deaths worldwide. Despite significant advancements in treatment, challenges such as drug resistance, side effects, metastasis recurrence continue to impact patient outcomes quality life. In response, there is growing interest complementary integrative approaches care. Traditional Chinese medicine (TCM), with its long history, abundant clinical experience, holistic perspective individualized approach, has garnered increasing attention for role lung prevention management. This review provides comprehensive overview advances TCM covering theoretical foundation, treatment principles, experiences evidence supporting efficacy. We also provide systematic summary preclinical mechanisms, through which impacts cancer, including induction cell death, reversal inhibition modulation immune responses. Additionally, future prospects are discussed, offering insights into expanded application integration modern address this challenging disease.

Language: Английский

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Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 25, 2025

To investigate the relationship between heart failure (HF) and gut microbiota-mediated energy metabolism, to explore role of Shenfu Injection in this process. In study, Adriamycin-induced chronic (CHF) rat model was used randomly divided into blank control group (Normal, n = 9), HF (Model, 12), treatment (SFI, positive drug (TMZ, 9). The changes microbiota structure were analyzed by 16S rRNA high-throughput sequencing, content short-chain fatty acids (SCFAs) detected targeted metabolomics technology, cardiac function metabolism-related indicators evaluated. Myocardial metabolism rats disordered, characterized reduced acid oxidation, enhanced anaerobic glycolysis glucose, mitochondrial damage, decreased ATP content; imbalanced, with a reduction beneficial bacteria, an increase conditional pathogenic impaired intestinal barrier function; Both trimetazidine improved myocardial function, but more significant regulating improving health; production SCFAs from increased, which may be closely related metabolism; SCFAs-producing bacteria Akkermansia Blautia played key development HF, their abundance positively correlated content. treating improve health microbiota, especially Blautia, thereby exerting therapeutic effects. This provides theoretical support for strategies based on microbiota.

Language: Английский

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Shenfu injection improves isoproterenol-induced heart failure in rats by modulating co-metabolism and regulating the trimethylamine-N-oxide - inflammation axis

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: June 20, 2024

Heart failure (HF) is a chronic condition that progressively worsens and continues to be major financial burden public health concern. The “gut-heart” axis provides an innovative perspective therapeutic strategy for preventing treating heart failure. Shenfu injection (SFI) Traditional Chinese Medicine-based treatment demonstrating potential as However, the precise mechanisms of SFI in are not completely characterized. In this study, HF models were established utilizing subcutaneous multipoint isoproterenol (ISO) at dosage 5 mg kg −1 ·d 7 days. Serum levels inflammatory biomarkers quantified using protein microarrays. Rat feces analyzed untargeted metabolomics research 16S rRNA sequencing. link between gut microbiota metabolites was examined MetOrigin Spearman correlation analysis. Our results show effectively enhances cardiac function rats with ISO-induced by potentially modulating pro-/anti-inflammatory imbalance reducing serum urine Trimethylamine-N-oxide (TMAO) levels. Moreover, significantly increases abundance Bacteroidota phylum level, thereby improving disrupted composition. Additionally, supplementation enriches specific genera known their capacity produce short-chain fatty acids. found associated three key metabolic pathways, revealed fecal metabonomics analysis, including pentose phosphate pathway, pyrimidine metabolism, purine metabolism. Metabolite tracing analysis Taurine hypotaurine metabolism microbial community. biosynthesis Pyrimidine Purine beta-alanine Naphthalene degradation, Pantothenate, CoA identified co-metabolic pathways microbes host. also correlated differentially expressed regulated microbiota. These suggest improves co-metabolism regulating TMAO-inflammation axis.

Language: Английский

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Using patient-reported outcomes in clinical studies for cardiovascular diseases of Traditional Chinese medicine worldwide: a cross-sectional study

BMC Complementary Medicine and Therapies, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 3, 2025

Cardiovascular diseases (CVD) represent a major global health challenge. Clinical research is increasingly leveraging patient perspectives to evaluate the efficacy of Traditional Chinese Medicine (TCM) in treating these conditions. This study reviews and summarizes application characteristics Patient-reported outcomes (PROs) TCM for CVD, overarching goal provide resource that can guide potential directions PROs endpoints future CVD clinical research. We searched studies from World Health Organization International Trials Registry Platform registered between January 1, 2010, February 22, 2025. The outcome types, whether PRO measures (PROMs) explicitly mentioned, design, phases,age, gender, geographic region were analyzed. classified specified into 15 categories based on Classification Diseases-11 (ICD-11),and compared their PROMs with Core Outcome Measures Effectiveness (COMET). A total 636 included, which 394 employed PROs. However, 103 did not specify utilized, including 33 involved syndrome scores. None most frequently used TCM-specific. studied disease - chronic coronary heart failure basically aligned COMET recommendations. In contrast, other COMET. have been commonly adopted as measures, usage steadily increasing. TCM-specific remains limited, revealing significant gap. recommended by should be further investigated across broader range categories. Furthermore, there an urgent need patient-centered scores, highlighting importance developing robust, standardized tailored this field.

Language: Английский

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Shen-fu Injection Modulates HIF- 1α/BNIP3-Mediated Mitophagy to Alleviate Myocardial Ischemia–Reperfusion Injury

Cardiovascular Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

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Using patient-reported outcomes in clinical studies for cardiovascular diseases of Traditional Chinese medicine worldwide: a cross-sectional study

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 17, 2024

Background and purpose: Patient-reported outcomes (PROs) are health condition assessments directly expressed by patients, providing a precise reflection of the patient's perspective. We aim to understand how PROs were being used provide suggestions for conducting high-quality clinical studies Traditional Chinese medicine (TCM) cardiovascular diseases (CVD). Methods: searched TCM CVD from World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) registered between January 1, 2010, December 31, 2023. Trial phases, study types, age, gender, interventions, regions countries, time trends, as primary/secondary/co-primary outcomes, PRO instruments explicitly specified or implicitly analyzed. classified that into 14 categories based on Classification Diseases-11 (ICD-11) ,and compared their with Core Outcome Measures in Effectiveness (COMET). Results: 487 identified. 194 did not mention use instruments. 250 tool, while 43 (studies registration mentioned PROs, but specified). Out 293 included 84 (17.2%) listed primary 144 (29.6%) secondary 65 (13.3%) co-primary outcomes. Chronic coronary heart disease (26.96%), hypertension (15.70%), failure (14.68%) most common studies. Furthermore, partially complied COMET's recommendations ,while other not. Frequently SAQ (Seattle Angina Questionnaire), TCMSS (TCM syndrome score), SF-8/12/36 (Short-Form 8/12/36-item Survey), VAS (Vsual Analog Scale). Conclusion: Over past decade, there has been continued increase measure investigations focused CVD. Research development core endpoints different could be improved. Given current challenges surrounding TCM, such inconsistent availability absence standardized it is crucial prioritize research establishing normalized scales specifically designed TCM.

Language: Английский

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An overview of the research progress on Aconitum carmichaelii Debx.:active compounds, pharmacology, toxicity, detoxification, and applications

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 118832 - 118832

Published: Sept. 1, 2024

Language: Английский

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Exploration of medicinal plants as potential therapeutics against COVID-19: molecular insights and drug development prospects with other significant medicinal information a retrospective exposition

Journal of Pharmacy and Pharmacology, Journal Year: 2024, Volume and Issue: 77(1), P. 18 - 31

Published: Aug. 21, 2024

The study aims to explore the potential of medicinal plants and their phytoconstituents as effective inhibitors coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 virus. focus is on investigating specific known for pharmacological properties, such as: antioxidant, anti-inflammatory, immunomodulatory effects, determine viability in developing COVID-19 treatments.

Language: Английский

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