Emerging insights into ferroptosis in cholangiocarcinoma (Review) DOI Open Access
Xiaoyue Zhao, Miao Zhang, Jing He

et al.

Oncology Letters, Journal Year: 2024, Volume and Issue: 28(6)

Published: Oct. 14, 2024

Cholangiocarcinoma (CCA) is a malignant tumor that arises within the biliary system, which exhibits progressively increasing incidence and poor patient prognosis. A thorough understanding of molecular pathogenesis drives progression CCA essential for development effective target therapeutic approaches. Ferroptosis driven by excessive iron accumulation catalysis, lipid peroxidation failure antioxidant defense systems. Key targets metabolism, metabolism systems involve molecules such as transferrin receptor, ACSL4 GPX4, respectively. Inhibitors ferroptosis include ferrostatin-1, liproxstatin-1, vitamin E coenzyme Q10. By contrast, compounds erastin, RSL3 FIN56 have been identified inducers ferroptosis. serves notable role in onset CCA. cells exhibit high sensitivity to aberrant these increases oxidative stress accumulation. The induction markedly reduces ability proliferate migrate. Certain agonists, cause peroxide build up GPX4 inhibition induce cells. Current serological markers, CA-199, low specificity difficulties diagnosis However, novel techniques, non-invasive liquid biopsy assays markers double-cortin-like kinase 1, could improve diagnostic accuracy. primarily treated with surgery chemotherapy. close association between mechanisms related regulatory pathways has demonstrated. Therefore, it be suggested multi-targeted approaches, inducers, chelating agents modulators YL-939, may treatment efficacy. Iron death-related genes, are highly expressed associated prognosis patients represent potential prognostic present review focused on p53 ACSL4, process targeted medications combination PDT peroxidation, Xc

Language: Английский

Organoids and spheroids: advanced in vitro models for liver cancer research DOI Creative Commons
Mirella Pastore,

A. Giachi,

Elena Spínola-Lasso

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 9, 2025

Liver cancer is a leading cause of cancer-related deaths worldwide, highlighting the need for innovative approaches to understand its complex biology and develop effective treatments. While traditional in vivo animal models have played vital role liver research, ethical concerns demand more human-relevant systems driven development advanced vitro models. Spheroids organoids emerged as powerful tools due their ability replicate tumor microenvironment facilitate preclinical drug development. are simpler 3D culture that partially recreate structure cell interactions. They can be used penetration studies high-throughput screening. Organoids derived from stem cells or patient tissues accurately emulate complexity functionality tissue. generated pluripotent adult cells, well specimens, providing personalized studying behavior responses. retain genetic variability original offer robust platform screening treatment strategies. However, both spheroids limitations, such absence functional vasculature immune components, which essential growth therapeutic The field modeling evolving, with ongoing efforts predictive reflect complexities human cancer. By integrating these tools, researchers gain deeper insights into accelerate novel

Language: Английский

Citations

1
Porphyrin-engineered nanoscale metal-organic frameworks: enhancing photodynamic therapy and ferroptosis in oncology DOI Creative Commons
Yutao Zou, Jiayi Chen, Xiaofang Luo

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 23, 2024

Photodynamic therapy and ferroptosis induction have risen as vanguard oncological interventions, distinguished by their precision ability to target vulnerabilities in cancer cells. therapy's non-invasive profile selective cytotoxicity complement ferroptosis' unique mode of action, which exploits iron-dependent lipid peroxidation, offering a pathway overcome chemoresistance with lower systemic impact. The synergism between photodynamic is underscored the depletion glutathione peroxidase four inhibitions therapy-induced reactive oxygen species, amplifying peroxidation enhancing ferroptotic cell death. This synergy presents an opportunity refine treatment modulating redox homeostasis. Porphyrin-based nanoscale metal-organic frameworks hybrid structures exceptional properties. These can serve platform for integrating through carefully designed functions. nanostructures be engineered deliver multiple therapeutic modalities simultaneously, marking pivotal advance multimodal therapy. review synthesizes recent progress porphyrin-modified combined ferroptosis, delineating mechanisms that underlie synergistic effects context. It underscores potential porphyrin-based advanced nanocarriers oncology, propelling field toward more efficacious tailored treatments.

Language: Английский

Citations

5
Glutathione Metabolism in Ferroptosis and Cancer Therapy DOI
Xiangfei Xue, Manyuan Wang,

Jiangtao Cui

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217697 - 217697

Published: April 1, 2025

Language: Английский

Citations

0
Conversion treatment for advanced intrahepatic cholangiocarcinoma: Opportunities and challenges DOI
Jun-Jie Liu, Mi Zhou, Tong Yuan

et al.

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(15)

Published: April 17, 2025

The prevalence of intrahepatic cholangiocarcinoma (ICC) is increasing globally. Despite advancements in comprehending this intricate malignancy and formulating novel therapeutic approaches over the past few decades, prognosis for ICC remains poor. Owing to high degree insidious onset ICC, numerous cases are detected at intermediate or advanced stages disease, hence eliminating chance surgical intervention. Moreover, because highly invasive characteristics recurrence metastasis postresection prevalent, leading a 5-year survival rate only 20%-35% following surgery. In decade, different methods treatment have been investigated, including transarterial chemoembolization, radioembolization, radiotherapy, systemic therapy, combination therapies. For certain patients with conversion may be utilized facilitate resection manage disease progression. This review summarizes definition downstaging presents clinical experience evidence concerning ICC.

Language: Английский

Citations

0
The Role of Cancer Organoids in Ferroptosis, Pyroptosis, and Necroptosis: Functions and Clinical Implications DOI Creative Commons

Dingci Lu,

Bairong Xia,

Tianquan Feng

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 659 - 659

Published: May 2, 2025

The enduring prevalence of cancer worldwide constitutes a significant public health challenge, thereby emphasizing the imperative for development therapeutic models capable accounting heterogeneity inherent in tumors. In this context, organoids have emerged as powerful tools studying tumor biology, providing valuable insights into complex interactions within microenvironment. Concurrently, research is increasingly focused on non-apoptotic forms regulated cell death (RCD)—including ferroptosis, pyroptosis, and necroptosis—which exert pivotal influences progression. Cancer not only recapitulate genetic phenotypic original tumors but also enable more precise investigations roles RCDs oncology. This review explores utility delineating molecular mechanisms underlying their implications biology treatment responses. By synthesizing recent findings, it highlights essential role organoid uncovering intricate details RCDs. Furthermore, emphasizes promising directions future that aim to deepen our understanding these pathways potential. integration necroptosis provides novel oncogenic facilitates targeted strategies. bridging with human pathophysiology, approach transformative framework dissecting enables design precision therapeutics selectively target machinery

Language: Английский

Citations

0
A cascaded amplification carrier-free nanoplatform for synergistic photothermal/ferroptosis therapy via dual antioxidant pathway disruption in cervical cancer DOI

Dihai Gu,

Xiaowen Liang, Zhiying Shao

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Dual-laser triggered carrier-free self-assembly nano-photosensitizers (Ir-TCF 3 P-FA NPs) with trimodal imaging performance significantly inhibited the progression of human cervical cancer through synergistic photothermal/ferroptosis therapy.

Language: Английский

Citations

0
Emerging insights into ferroptosis in cholangiocarcinoma (Review) DOI Open Access
Xiaoyue Zhao, Miao Zhang, Jing He

et al.

Oncology Letters, Journal Year: 2024, Volume and Issue: 28(6)

Published: Oct. 14, 2024

Cholangiocarcinoma (CCA) is a malignant tumor that arises within the biliary system, which exhibits progressively increasing incidence and poor patient prognosis. A thorough understanding of molecular pathogenesis drives progression CCA essential for development effective target therapeutic approaches. Ferroptosis driven by excessive iron accumulation catalysis, lipid peroxidation failure antioxidant defense systems. Key targets metabolism, metabolism systems involve molecules such as transferrin receptor, ACSL4 GPX4, respectively. Inhibitors ferroptosis include ferrostatin-1, liproxstatin-1, vitamin E coenzyme Q10. By contrast, compounds erastin, RSL3 FIN56 have been identified inducers ferroptosis. serves notable role in onset CCA. cells exhibit high sensitivity to aberrant these increases oxidative stress accumulation. The induction markedly reduces ability proliferate migrate. Certain agonists, cause peroxide build up GPX4 inhibition induce cells. Current serological markers, CA-199, low specificity difficulties diagnosis However, novel techniques, non-invasive liquid biopsy assays markers double-cortin-like kinase 1, could improve diagnostic accuracy. primarily treated with surgery chemotherapy. close association between mechanisms related regulatory pathways has demonstrated. Therefore, it be suggested multi-targeted approaches, inducers, chelating agents modulators YL-939, may treatment efficacy. Iron death-related genes, are highly expressed associated prognosis patients represent potential prognostic present review focused on p53 ACSL4, process targeted medications combination PDT peroxidation, Xc

Language: Английский

Citations

0