International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 669, P. 125101 - 125101
Published: Dec. 19, 2024
Language: Английский
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 669, P. 125101 - 125101
Published: Dec. 19, 2024
Language: Английский
Published: Jan. 1, 2025
Language: Английский
Citations
0International Immunopharmacology, Journal Year: 2025, Volume and Issue: 151, P. 114334 - 114334
Published: Feb. 27, 2025
Language: Английский
Citations
0Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: Nov. 15, 2024
In recent years, some components and active ingredients from the herbal formula “eight famous herbals in Zhejiang” (Zhe-Ba-Wei) have been reported to possess antitumor properties. However, there is still no systemic study on role mechanism of Zhe-Ba-Wei cancer. To systematically investigate anticancer efficacy Zhe-Ba-Wei, we first identified 17 with gene targets associated various types tumors. Second, screened these their responding multiple shared by analyzing convergence diverse tumor-specific target sites four crucial (ferulic acid, quercetin, rutin, luteolin), which were characterized 27 overlapping targets. Third, subsequently mapped onto Kyoto Encyclopedia Genes Genomes (KEGG) pathway Gene Ontology term, among total potential targets, 12 involved plasma membrane function. Fourth, investigated binding affinities between such as EGFR MET, both are well-known oncogenes cancers. Subsequently, an investigation computational ADMET properties showed that most exhibited good Finally, found three luteolin, quercetin) could inhibit proliferation non-small cell lung cancer cells decrease protein expression a concentration-dependent manner. All results shed light bioactive components, pharmacological effects, drug development utilization aiming provide useful support for its further research clinical application.
Language: Английский
Citations
0International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 669, P. 125101 - 125101
Published: Dec. 19, 2024
Language: Английский
Citations
0