MiRNAs function in the development of resistance against doxorubicin in cancer cells: targeting ABC transporters DOI Creative Commons
Xinyan Lu, Hongxu Jin

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 29, 2024

Resistance to chemotherapeutic agents poses a significant challenge in cancer treatment, particularly with doxorubicin, widely used drug for various cancers, including breast cancer, leukaemia, osteosarcoma, and gastrointestinal cancers. This review aims elucidate the critical role of microRNAs (miRNAs) development doxorubicin resistance, focusing on their interactions ATP-binding cassette (ABC) transporters. Despite extensive research, molecular mechanisms governing resistance still need be completed, regarding regulatory influence miRNAs ABC transporter expression. By analyzing current literature, this identifies notable gap: lack comprehensive insight into how specific modulate expression activity transporters cells, contributing resistance. We systematically examine recent findings interplay between transporters, providing detailed assessment potential therapeutic strategies that leverage miRNA modulation overcome Ultimately, underscores significance integrating research existing frameworks enhance efficacy treatment.

Language: Английский

MiRNAs: main players of cancer drug resistance target ABC transporters DOI
Forogh Mohammadi, Masoumeh Nejatollahi, Farhad Sheikhnia

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Language: Английский

Citations

0
NGR‐Modified CAF‐Derived exos Targeting Tumor Vasculature to Induce Ferroptosis and Overcome Chemoresistance in Osteosarcoma DOI Creative Commons

Jianxin Du,

Xiangwei Meng, Minghao Yang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Osteosarcoma (OS) chemoresistance presents a significant clinical challenge. This study aims to investigate the potential of using tumor vascular-targeting peptide NGR-modified cancer-associated fibroblasts (CAFs)-derived exosomes (exos) deliver circ_0004872-encoded small peptides promoting autophagy-dependent ferroptosis reverse in OS. Through combined single-cell transcriptome analysis and high-throughput sequencing, it identified circ_0004872 associated with chemoresistance. Subsequent experiments demonstrated that encoded by this Circular RNA (circRNA) can effectively enhancing OS cell sensitivity chemotherapy via mechanism ferroptosis. Moreover, vitro vivo results confirmed efficient delivery CAFs-derived exo-packaged circ_0004872-109aa cells, thereby improving targeted therapy efficacy. not only offers novel strategy overcome but also highlights application value utilizing exos for drug delivery.

Language: Английский

Citations

0
In silico identification of multidrug resistance gene (MDR)-targeted transposon miRNAs in human cancer DOI
Seda Mesci

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Journal Year: 2025, Volume and Issue: 830, P. 111903 - 111903

Published: Jan. 1, 2025

Language: Английский

Citations

0
Therapeutic potential of microRNA-506 in cancer treatment: mechanisms and therapeutic implications DOI Creative Commons

Sha Mao,

Junyan Li, Jiahui Huang

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 3, 2025

Cancer is a complex and highly lethal disease marked by unchecked cell proliferation, aggressive behavior, strong tendency to metastasize. Despite significant advancements in cancer diagnosis treatment, challenges such as early detection difficulties, drug resistance, adverse effects of radiotherapy or chemotherapy continue threaten patient survival. MicroRNAs (miRNAs) have emerged critical regulators biology, with miR-506 being extensively studied recognized for its tumor-suppressive across multiple types. This review examines the regulatory mechanisms common cancers, focusing on role competing endogenous RNA (ceRNA) network apoptosis, migration. We also discuss potential therapeutic target overcoming resistance treatment. Overall, these insights underscore promise developing novel therapies.

Language: Английский

Citations

0
Circ_0000395 promotes cell growth, metastasis and oxaliplatin resistance by regulating miR-153-5p/MYO6 in colorectal cancer DOI
Liang Xiao, Yan Zhu,

Haixia Xu

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155476 - 155476

Published: July 17, 2024

Language: Английский

Citations

1
MiRNAs function in the development of resistance against doxorubicin in cancer cells: targeting ABC transporters DOI Creative Commons
Xinyan Lu, Hongxu Jin

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 29, 2024

Resistance to chemotherapeutic agents poses a significant challenge in cancer treatment, particularly with doxorubicin, widely used drug for various cancers, including breast cancer, leukaemia, osteosarcoma, and gastrointestinal cancers. This review aims elucidate the critical role of microRNAs (miRNAs) development doxorubicin resistance, focusing on their interactions ATP-binding cassette (ABC) transporters. Despite extensive research, molecular mechanisms governing resistance still need be completed, regarding regulatory influence miRNAs ABC transporter expression. By analyzing current literature, this identifies notable gap: lack comprehensive insight into how specific modulate expression activity transporters cells, contributing resistance. We systematically examine recent findings interplay between transporters, providing detailed assessment potential therapeutic strategies that leverage miRNA modulation overcome Ultimately, underscores significance integrating research existing frameworks enhance efficacy treatment.

Language: Английский

Citations

1