The impact of different dietary flavonoids on the risk of coronary heart disease in cancer patients and that on the prognosis of patients with cancer and coronary heart disease DOI

Jingjing Zhu,

Tao Xu,

Xu Cao

et al.

European Journal of Cancer Prevention, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 9, 2024

The purpose of this study is to explore the risk coronary heart disease (CHD) in cancer patients who consume different flavonoids, and impact flavonoids on prognosis with CHD. We extracted dietary data 1454 diagnosed from National Health Nutrition Examination Survey Food Nutrient Database for Dietary Studies. Logistic regression analysis was used relationship between intake Cox proportional hazard model 148 Malvidin increased CHD by 1% [odds ratio (OR) = 1.01, 95% confidence interval (CI): 1.00–1.02, P < 0.05] patients, while epicatechin isorhamnetin reduced 3% (OR 0.97, CI: 0.94–1.00, 0.05) 15% 0.85, 0.72–1.00, 0.05), respectively. Adjusted age, sex, race, malvidin decreased showed no effect ( > 0.05). No had For cancer, consuming increases CHD, reduces risk. Consuming has

Language: Английский

A Systematic Review: Quercetin—Secondary Metabolite of the Flavonol Class, with Multiple Health Benefits and Low Bioavailability DOI Open Access
Olimpia Daniela Frenț,

Liana Ștefan,

Claudia Mona Morgovan

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12091 - 12091

Published: Nov. 11, 2024

The main goal of this systematic review on the flavonol class secondary metabolite quercetin is to evaluate and summarize existing research quercetin's potential health benefits, therapeutic properties, effectiveness in disease prevention treatment. In addition evaluating for drug development with fewer side effects lower toxicity, type attempts collect scientific evidence addressing roles as an antioxidant, anti-inflammatory, antibacterial, anticancer agent. first part, we analyze various flavonoid compounds, focusing their chemical structure, classification, natural sources. We highlight most recent biological activities reported literature. Among these pay special attention quercetin, detailing its physicochemical process biosynthesis plants. also present sources emphasize such antioxidant anti-inflammatory effects. Additionally, discuss methods enhance bioavailability, analyzing latest effective delivery systems based quercetin.

Language: Английский

Citations

8
Comparing International Guidelines for the Remission of Hypertension After Bariatric Surgery DOI Creative Commons

Carina Vieira Dias,

Ana Lúcia Silva, Joana Ida Dias

et al.

Clinics and Practice, Journal Year: 2025, Volume and Issue: 15(1), P. 11 - 11

Published: Jan. 2, 2025

Obesity remains a global health concern and is associated with increased risk of type 2 diabetes, hypertension, cardiovascular disease overall. Dissimilar hypertension guidelines are available for clinicians, namely those prepared by the American Heart Association (AHA) European Society Cardiology (ESC), which may lead to distinctive appreciation outcomes patients obesity after bariatric metabolic surgery, such as remission. The main goal this study was compare effects applying stricter versus looser (ESC) blood pressure criteria on diagnosis pre-bariatric surgery remission assessment one year post-op. A retrospective analysis clinical data from who underwent surgical treatment at single university hospital performed. To evaluate improvement or remission, two different types (BP) categorization were considered (based AHA ESC guidelines), in each patient would fit according their BP values pre- (m0) 12 months postoperative (m12). From sample 153 submitted obesity, more based guideline (130 vs. 102; p < 0.001), while higher rate observed when following (58.82 53.08%). Baseline patients' characteristics outcome mostly independent used (p > 0.05), where only age systolic relatively "ESC groups". We conclude that minor differences exist between used. If evaluated guidelines, it expected less be, least numerically, higher.

Language: Английский

Citations

0
Mechanisms of isorhamnetin inhibition of osteoclast differentiation: insights from molecular dynamics simulations and in vitro/in vivo experiments DOI Creative Commons
Yi Zhou, Shaoshuo Li,

Bowen Hong

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

Background Osteoporosis (OP) represents a widespread bone remodeling disorder within the domain of orthopedics, markedly compromising quality life in elderly population. The need to develop more efficient therapeutic approaches attenuate resorption by suppressing excessive activation osteoclasts (OCs) remains urgent. plant flavonoid Isorhamnetin (Iso), recognized for its potent antioxidant properties, has been subject extensive research regarding potential treating bone-related conditions. Method This study adopts comprehensive methodology evaluate Iso’s impact on metabolism and possibilities OP. By integrating network pharmacology, molecular dynamics simulations, surface plasmon resonance (SPR), we performed vitro phenotypic analyses systematically inhibitory effect Iso OC differentiation. mechanisms behind inhibition differentiation were further elucidated. In vivo testing was also substantiate effects an OP animal model. Results At low concentrations, showed no cytotoxicity did not interfere with cell proliferation RAW 264.7 cells. effectively inhibited RANKL-induced osteoclast these cells, while downregulating related genes levels ( Nfatc1 , Cts k, Trap c-Fos ). Molecular simulations confirmed dual binding both RANKL RANK. KEGG pathway enrichment analysis results indicated that modulates MAPK, NF-κB/PI3K-AKT, calcium signaling pathways. Western blot revealed treatment targeting RANKL/RANK significantly downregulated phosphorylation JNK, P38, AKT, p65. Concurrently, stimulation increased IκBα expression, thereby rescuing degradation. Furthermore, demonstrated robust reactive oxygen species . OVX mice, density, modulated serum markers, transcriptional marker genes. Conclusion exhibits selectively disrupting RANKL-RANK interaction. intervention expression intracellular transcription factors multiple pathways, inhibiting maturation OCs. Through mitigating OC-mediated loss, holds significant promise as agent

Language: Английский

Citations

0
Isorhamnetin inhibits hypertrophic scar formation through TGF-β1/Smad and TGF-β1/CREB3L1 signaling pathways DOI Creative Commons
Junzheng Wu,

Yajuan Song,

Jianzhang Wang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e33802 - e33802

Published: June 29, 2024

Hypertrophic scar (HS) is a common fibrotic skin disease that occurs secondary to burns or injuries. The activation of the TGF-β signaling pathway contributes immensely HS formation. Isorhamnetin (ISO) type flavonoid compound exerts an antifibrotic effect via suppression. However, whether ISO can inhibit formation yet be elucidated. This study aimed examine influence on pathogenesis and signaling, especially downstream molecules networks facilitate

Language: Английский

Citations

3
Phenolic Profile and Antioxidant Capacity of Invasive Solidago canadensis L.: Potential Applications in Phytopharmacy DOI Creative Commons

Mirela Uzelac Božac,

Danijela Poljuha,

Slavica Dudaš

et al.

Plants, Journal Year: 2024, Volume and Issue: 14(1), P. 44 - 44

Published: Dec. 26, 2024

Canadian goldenrod (Solidago canadensis L.), an invasive plant in Europe, is known for its allelopathic activity and rich bioactive compounds like flavonoids phenolic acids, with significant pharmacological potential. This study presents the LC-MS profiles of leaf flower extracts from S. canadensis, alien Istria region (Croatia). Total phenolics (TP) (45.78–110.68 mg GAE/g DW) non-flavonoids (TNF) (28.38–72.20 were found to be more abundant ethanolic than methanolic extracts. The antioxidant capacity (AC), as measured by ABTS, DPPH, FRAP assays, was higher compared A non-targeted metabolomics approach used, 41 leaves 36 flowers identified, hydroxycinnamic acids flavonols being most abundant. 5-caffeoylquinic acid quantitatively predominant extracts, while quercetin-3-rutinoside dominated Five leaf-specific identified (dicaffeoylquinic 2, 4-p-coumaroylquinic 1, p-hydroxybenzoic acid, quercetin-3-rhamnoside, quercetin acetylhexoside 1), suggesting targeted extraction different applications. highlights therapeutic potential underscores need further research on bioavailability, efficacy, safety compounds, potentially transforming this ecological threat into a valuable resource drug development.

Language: Английский

Citations

1
The impact of different dietary flavonoids on the risk of coronary heart disease in cancer patients and that on the prognosis of patients with cancer and coronary heart disease DOI

Jingjing Zhu,

Tao Xu,

Xu Cao

et al.

European Journal of Cancer Prevention, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 9, 2024

The purpose of this study is to explore the risk coronary heart disease (CHD) in cancer patients who consume different flavonoids, and impact flavonoids on prognosis with CHD. We extracted dietary data 1454 diagnosed from National Health Nutrition Examination Survey Food Nutrient Database for Dietary Studies. Logistic regression analysis was used relationship between intake Cox proportional hazard model 148 Malvidin increased CHD by 1% [odds ratio (OR) = 1.01, 95% confidence interval (CI): 1.00–1.02, P < 0.05] patients, while epicatechin isorhamnetin reduced 3% (OR 0.97, CI: 0.94–1.00, 0.05) 15% 0.85, 0.72–1.00, 0.05), respectively. Adjusted age, sex, race, malvidin decreased showed no effect ( > 0.05). No had For cancer, consuming increases CHD, reduces risk. Consuming has

Language: Английский

Citations

0