Effect of Statin Lipophilicity on the Proliferation of Hepatocellular Carcinoma Cells DOI Creative Commons

Goda Glebavičiūtė,

Akshay Kumar Vijaya, Giulio Preta

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(6), P. 455 - 455

Published: June 19, 2024

The HMG-CoA reductase inhibitors, statins, are drugs used globally for lowering the level of cholesterol in blood. Different clinical studies statins cancer patients have indicated a decrease mortality, particularly using lipophilic compared to those on hydrophilic statins. In this paper, we selected two structurally different (simvastatin and pravastatin) with lipophilicities investigated their effects proliferation apoptosis hepatocellular carcinoma cells. Lipophilic simvastatin highly influences cell growth survival time- concentration-dependent manner, while pravastatin, due its structure limited cellular uptake, showed minimal cytotoxic effects.

Language: Английский

Concomitant Statin Use and Survival in Patients With Cancer on Immune Checkpoint Inhibitors: A Meta-Analysis DOI

Yonghe Liao,

Yuxuan Lin,

Xinqi Ye

et al.

JCO Oncology Practice, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

PURPOSE The prognostic significance of concomitant statin use in cancer treatment with immune checkpoint inhibitors (ICIs) remains a subject ongoing investigation. This study aims to clarify the value this patient population and provide robust, evidence-based foundation guide therapeutic decisions. METHODS A systematic search strategy was used across multitude digital archives exhaustively identify all relevant academic literature published up until June 20, 2024. Studies English that reported hazard ratios (HRs) for overall survival (OS) and/or progression-free (PFS), along corresponding 95% CIs, were considered eligible inclusion. Meta-analyses conducted calculate combined HRs CIs. RESULTS total 25 studies, involving 46,154 patients cancer, included meta-analysis. pooled results indicated linked better OS (HR, 0.80 [95% CI, 0.71 0.92]) PFS 0.69 under ICI therapy. Sensitivity analyses further validated consistency robustness results. CONCLUSION On basis available clinical evidence, is an improved prognosis oncology on ICI-based These observations underscore potential as important adjunctive therapy paradigm ICI-treated thereby establishing their key consideration management strategies. Further randomized controlled trials are imperative validate effect within realm

Language: Английский

Citations

3
Enhancing the Efficacy of CAR-T Cell Production Using BX795 and Rosuvastatin in a Serum-Free Medium DOI Open Access

Abed Alkader Yassin,

Rajashri Banerji, Baisali Bhattacharya

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2988 - 2988

Published: March 25, 2025

Chimeric Antigen Receptor T-cell (CAR-T) therapy has emerged as a transformative approach for cancer treatment, demonstrating remarkable success in patients with relapsed and refractory hematological malignancies. However, challenges persist optimizing CAR-T cell production improving therapeutic outcomes. One of the major hurdles is efficiency retroviral or lentiviral transduction during manufacturing. Additionally, heterogeneity populations isolated from can impact effectiveness persistence vivo. This article explores novel strategy to address these by focusing on serum-free medium additive optimization. We propose unique that incorporates culturing T cells Nutri-T medium, along 24 h exposure combined low concentrations BX795 rosuvastatin, enhance efficacy functionality cells. The results presented here provide promising insights into potential this produce more effective immunotherapy, ultimately advancing field benefiting worldwide.

Language: Английский

Citations

0
Lipids in the tumor microenvironment: immune modulation and metastasis DOI Creative Commons
Gloria Pascual, Salvador Aznar Benitah

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 26, 2024

Tumor cells can undergo metabolic adaptations that support their growth, invasion, and metastasis, such as reprogramming lipid metabolism to meet energy demands promote survival in harsh microenvironmental conditions, including hypoxia acidification. Metabolic rewiring, especially alterations metabolism, not only fuel tumor progression but also influence immune cell behavior within the microenvironment (TME), leading immunosuppression evasion. These processes, turn, may contribute metastatic spread of cancer. The diverse profiles subsets, driven by TME tumor-derived signals, complex landscape tumors, affecting activation, differentiation, effector functions. Understanding targeting heterogeneity among subsets will be crucial for developing effective cancer immunotherapies overcome evasion mechanisms enhance antitumor immunity.

Language: Английский

Citations

3
Mechanism of atorvastatin in treating hepatocellular carcinoma: a study based on network pharmacology, molecular docking, and bioinformatics analysis DOI
Youwen Hu, Yangyang Xiao

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Language: Английский

Citations

1
Effect of Statin Lipophilicity on the Proliferation of Hepatocellular Carcinoma Cells DOI Creative Commons

Goda Glebavičiūtė,

Akshay Kumar Vijaya, Giulio Preta

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(6), P. 455 - 455

Published: June 19, 2024

The HMG-CoA reductase inhibitors, statins, are drugs used globally for lowering the level of cholesterol in blood. Different clinical studies statins cancer patients have indicated a decrease mortality, particularly using lipophilic compared to those on hydrophilic statins. In this paper, we selected two structurally different (simvastatin and pravastatin) with lipophilicities investigated their effects proliferation apoptosis hepatocellular carcinoma cells. Lipophilic simvastatin highly influences cell growth survival time- concentration-dependent manner, while pravastatin, due its structure limited cellular uptake, showed minimal cytotoxic effects.

Language: Английский

Citations

0