Bioactive Zn–V–Si–Ca Glass Nanoparticle Hydrogel Microneedles with Antimicrobial and Antioxidant Properties for Bone Regeneration in Diabetic Periodontitis

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Periodontitis is a chronic inflammatory condition affecting the periodontal tissue. This worsens in diabetic patients due to oxidative stress and inflammation. Herein, we investigated treatment using bioactive Zn–V–Si–Ca glass nanoparticle hydrogel microneedles. The microneedles contain nanoparticles codoped with zinc vanadium ions. They also include gallic acid oxidized methacrylated hyaluronic acid. These address bacterial dysbiosis periodontitis. provide antibacterial antioxidant effects. deliver therapeutic agents directly into gingival enhances drug retention absorption by penetrating mucosal barrier. In vitro studies demonstrated biocompatibility, excellent properties, acceptable mechanical properties. Meanwhile, microneedle patches properties effective against Gram-negative pathogen as well Gram-positive oral bacterium. vivo experiments were performed rat model Results showed significant improvement alveolar bone regeneration. modulated microenvironment effectively. Ribonucleic sequencing revealed downregulation of JAK-STAT NF-κB inflammation signaling pathways. work presents distinctive approach suppressing response modulate immune responses for purpose treating periodontitis early.

Language: Английский

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Advancements in non-invasive diagnosis of gastric cancer

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(6)

Published: Jan. 10, 2025

Gastric cancer (GC), a multifaceted and highly aggressive malignancy, represents challenging healthcare burdens globally, with high incidence mortality rate. Although endoscopy, combined histological examination, is the gold standard for GC diagnosis, its cost, invasiveness, specialized requirements hinder widespread use screening. With emergence of innovative technologies such as advanced imaging, liquid biopsy, breath tests, landscape diagnosis poised radical transformation, becoming more accessible, less invasive, efficient. As non-invasive diagnostic techniques continue to advance undergo rigorous clinical validation, they hold promise significantly impacting patient outcomes, ultimately leading better treatment results improved quality life patients GC.

Language: Английский

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Flexibility, Photothermal Property, Antibacterial Ability, and Mineralization Activity of Cu/Mn-Doped Inorganic Nanofibers

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

Inorganic nanofibers have emerged as a promising frontier in biomedical research thanks to their unique nanomorphology and bioactivity. Furthermore, the ions released from these inorganic biomaterials play crucial role determining cell identity driving tissue-specific functions. Notably, Cu Mn, which are essential trace elements human body, significant roles promoting bone health participating metabolic processes. Therefore, this study, series of Cu/Mn-doped SiO2–CaO composite (CNFs) prepared by sol–gel electrospinning were obtained, morphology, flexibility, mineralization property, photothermal antibacterial activity studied. Experimental has shown that 2.5Cu 2.5Mn CNFs calcined at 800 °C best Cu/Mn content or calcination temperature increases, flexibility decreases. In addition, 10Cu 10Mn reaching temperatures 65 62 under near-infrared irradiation (NIR) 2 W cm–2 wet state, respectively, increase results decreased temperatures. The bacterial inhibition rates (5Cu 5Mn) with without NIR over 89 68%, respectively. experiment also proved excellent activity. activity, ability show great application potential treatment tumors defect-related diseases.

Language: Английский

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The Impact of Calcium Overload on Cellular Processes: Exploring Calcicoptosis and Its Therapeutic Potential in Cancer

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13727 - 13727

Published: Dec. 23, 2024

The key role of calcium in various physiological and pathological processes includes its involvement forms regulated cell death (RCD). concept ‘calcicoptosis’ has been introduced as a calcium-induced phenomenon associated with oxidative stress cellular damage. However, definition remains controversial within the research community, some considering it general form overload stress, while others view tumor-specific death. This review examines context established RCD mechanisms such apoptosis, necroptosis, ferroptosis, others. It further analyzes intricate relationship between dysregulation emphasizing that often triggers death, may not represent an entirely new type but rather extension known pathways. purpose this paper is to discuss implications perspective for cancer therapy focusing on calcium-based nanoparticles. By investigating connections dynamics pathways, contributes advancement our understanding calcicoptosis possible therapeutic uses.

Language: Английский

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