Microplastics and nanoplastics: emerging threats to cardiovascular health – a comprehensive review DOI Open Access
Hamza Irfan,

Haider Irfan,

M. A. Khan

et al.

Annals of Medicine and Surgery, Journal Year: 2024, Volume and Issue: 87(1), P. 209 - 216

Published: Dec. 11, 2024

Global plastic production surged to 400.3 million metric tons in 2022, contributing significantly environmental pollution. Projections estimate that 13.2 billion of waste will be present ecosystems by 2050. This increase has led substantial human exposure microplastics (MPs) and nanoplastics (NPs). While their general health impacts are well-documented, the specific effects on cardiovascular remain underexplored. review aims examine presence MPs NPs environment, routes exposure, toxicological implications for system (CVS), focusing oxidative stress, apoptosis, cardiac fibrosis, major adverse events (MACE). A comprehensive literature was conducted using PubMed, Scopus, Google Scholar. Relevant studies from past 10 years were selected based keywords like "microplastics," "nanoplastics," "cardiovascular health." found air, water, food, entering body primarily through inhalation, ingestion, dermal contact. These particles induce mitochondrial dysfunction, which impair health. have been detected arterial tissues, particularly atherosclerotic plaques, correlating with increased MACE risk. MP is linked VC, reduced vessel flexibility, thrombosis severity. Additionally, contribute inflammation lipid metabolism disruption, further exacerbate heart disease. The evidence suggests a concerning link between health, highlighting urgent need research understand long-term CVSs.

Language: Английский

The histopathological and functional consequences of microplastic exposure DOI Creative Commons

Yujeong Lee,

Min Kyung Sung, Soo‐Eun Sung

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 7(1)

Published: Jan. 11, 2025

As the production, usage, and disposal of plastics increase, microplastics generated—plastic particles smaller than 5 mm—increases, exacerbating environmental pollution. In turn, various organisms become increasingly exposed to contaminated environments, potentially affecting humans through food chain. Crucial findings from in vivo experiments indicate histopathological changes caused by impact morphology physiological function organisms. This study describes induced across circulatory, nervous, digestive, respiratory, reproductive systems explains associated functional alterations. Except nervous system, main morphological involve degenerative throughout body, such as apoptosis, inflammation, fibrosis. Most were inflammatory responses microplastics, leading fibrosis subsequent impairments. Various studies confirm that stimulate cells, increased reactive oxygen species cell death. Consequently, these impair related systemic functions. review highlights fundamental organs cells due discusses limitations involving showing no changes.

Language: Английский

Citations

2
Multi Omics Applications in Biological Systems DOI Creative Commons
Cristian D. Gutierrez Reyes, Gerardo Alejo‐Jacuinde, Benjamin Perez Sanchez

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(6), P. 5777 - 5793

Published: June 11, 2024

Traditional methodologies often fall short in addressing the complexity of biological systems. In this regard, system biology omics have brought invaluable tools for conducting comprehensive analysis. Current sequencing capabilities revolutionized genetics and genomics studies, as well characterization transcriptional profiling dynamics several species sample types. Biological systems experience complex biochemical processes involving thousands molecules. These occur at different levels that can be studied using mass spectrometry-based (MS-based) analysis, enabling high-throughput proteomics, glycoproteomics, glycomics, metabolomics, lipidomics Here, we present most up-to-date techniques utilized completion Additionally, include some interesting examples applicability multi to a variety

Language: Английский

Citations

13
Degradation of Polymer Materials in the Environment and Its Impact on the Health of Experimental Animals: A Review DOI Open Access
X. Zhang, Zhenxing Yin,

Songbai Xiang

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(19), P. 2807 - 2807

Published: Oct. 3, 2024

The extensive use of polymeric materials has resulted in significant environmental pollution, prompting the need for a deeper understanding their degradation processes and impacts. This review provides comprehensive analysis environment impact on health experimental animals. It identifies common polymers, delineates pathways, describes resulting products under different conditions. covers physical, chemical, biological mechanisms, highlighting complex interplay factors influencing these processes. Furthermore, it examines implications products, using animals as proxies assessing potential risks to human health. By synthesizing current research, focuses studies related small organisms (primarily rodents invertebrates, supplemented by fish mollusks) explore effects polymer living underscores urgency developing implementing effective waste management strategies. These strategies are crucial mitigating adverse impacts degradation, thus promoting more sustainable interaction between activities natural environment.

Language: Английский

Citations

12
Microplastics and Nanoplastics Increase Major Adverse Cardiac Events in Patients with Myocardial Infarction DOI Creative Commons
Yun Zhang, Qiang Gao, Qiang Gao

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137624 - 137624

Published: Feb. 19, 2025

Microplastics and nanoplastics (MNPs) have implicated in cardiovascular disease preclinical studies. Our objective is to investigate the relationship between MNPs coronary arteries major adverse cardiac events (MACE) patients with myocardial infarction (MI).We conducted a prospective observational study involving undergoing angiography for MI. Coronary blood samples were analyzed presence of using pyrolysis-gas chromatography-mass spectrometry. A total 142 enrolled, 110 completing 31.5-month follow-up. Among them, 48 (43.6 %) had detectable polystyrene, 79 (71.8 polyethylene, 105 (95.4 polyvinyl chloride (PVC), 68 (61.8 polyamide 66 their blood. PVC concentration was higher who experienced MACE. Furthermore, levels positively associated proinflammatory factors (IL-1β, IL-6, IL-18, TNF-α), odds MACE (OR: 1.090, 95 %CI: 1.032-1.1523, P = 0.002). Notably, each 10-unit increase PVC, there 1.374-fold risk (OR=2.374, 1.366-4.128, Additionally, we collected thrombus from an additional 21 MI patients, finding that thrombi correlated inflammatory markers monocyte/macrophage infiltration.

Language: Английский

Citations

1
Microplastics and nanoplastics in cardiovascular disease—a narrative review with worrying links DOI Creative Commons

Haixiang Zheng,

Gianpaolo Vidili, Gavino Casu

et al.

Frontiers in Toxicology, Journal Year: 2024, Volume and Issue: 6

Published: Oct. 10, 2024

With the widespread use of plastic products and increase in waste, microplastics nanoplastics (MNPs) have become an important issue global environmental pollution. In recent years, increasing number studies shown that MNPs may negative impacts on human health. This review aimed to explore association between cardiovascular disease provide outlook for future research. Research has there be a link exposure disease. Laboratory animals exposed often exhibit abnormalities system, such as increased blood pressure, vascular inflammation, myocardial damage. Epidemiological surveys also revealed people are more likely suffer from diseases, hypertension infarction. Although specific impact mechanism is not fully understood, several possible pathways action, including effects toxic substances interference with endocrine system. summary, health, but further research needed confirm its extent guide relevant public health policies.

Language: Английский

Citations

6
Far‐Reaching Impact of Microplastics on Agricultural Systems: Options for Mitigation and Adaptation DOI Creative Commons

S. Rajendrakumar,

Dil Bahadur Rahut

Land Degradation and Development, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

ABSTRACT Microplastics has emerged as a pervasive pollutant with far‐reaching implications for agriculture. This review paper evaluates existing research on microplastics in agricultural systems, exploring their impacts land, crop growth, farm animals, and consumer health. Using the PRISMA framework systematic process, 811 papers were identified initial search, only 164 used this study after following inclusion exclusion criteria. Our found that high‐density polyethylene polyvinyl chloride are widely plastic types agriculture, followed by polypropylene, polystyrene, terephthalate. prevalence is likely due to extensive use of plastics agriculture such mulching, handling harvested products, bags fertilizers pesticides, samplings, seed storage. The serious adverse consequences crops, animal health, soil, consumers. It also highlights need comprehensive strategies mitigate these impacts, using bioplastics, application treated water irrigation, proper disposal plastics, sustainable practices. Adaptation measures soil remediation, different microplastic removal technologies, policy interventions emerge crucial strategy cope pollution. concludes call interdisciplinary better understand complexities pollution develop solutions protect natural ecosystems, human food security.

Language: Английский

Citations

0
zMicroplastics and nanoplastics co-exposure modulates chromium bioaccumulation and physiological responses in rats DOI Creative Commons
Damir Suljević, Patrik Karlsson, Muhamed Fočak

et al.

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109421 - 109421

Published: March 1, 2025

The environmental fragmentation of plastics generates a mixture plastic particles various sizes, which frequently co-occur with other mobile and persistent pollutants. Despite the prevalence such scenarios, interaction between micro- nanoplastics (MNPs) their combined effects pollutants, as highly toxic hexavalent chromium (Cr(VI)), remain almost entirely unexplored in mammalian species. This study demonstrated that nanoplastic microplastic co-aggregate together influence Cr bioaccumulation patterns related physiological alterations rats. Following four-week repeated intragastric exposure Wistar rats to MNPs Cr(VI), either alone or combination, significantly enhanced liver, heart, brain, skin. Under co-exposure conditions, Cr(VI) was primary driver cellular observed blood, including shifts immune cell subpopulations (e.g., neutrophils, lymphocytes) red blood indices, while serum biochemistry reflected limited stress. per se decreased creatine kinase activity increased cholesterol levels. In summary, polystyrene increase distribution bioavailability, but does not uniformly exacerbate toxicity. Instead, may selectively alter responses, emphasizing need for deeper understanding potential health risks.

Language: Английский

Citations

0
Polystyrene microplastics impair brown and beige adipocyte function via the gut microbiota-adipose tissue crosstalk in high-fat diet mice DOI
Guangning Kou, Yao Shuai, Amin Ullah

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138225 - 138225

Published: April 1, 2025

Language: Английский

Citations

0
Effects of polystyrene microplastics on mice cardiac tissue structure: Protective role of resveratrol DOI
Somaye Zangene, Samaneh Goorani, Hassan Morovvati

et al.

Chemosphere, Journal Year: 2025, Volume and Issue: 379, P. 144406 - 144406

Published: April 21, 2025

Language: Английский

Citations

0
Effects of microplastics on the immune system: How much should we worry? DOI Creative Commons
Claudia Vanetti,

Martina Broggiato,

Stefania Pezzana

et al.

Immunology Letters, Journal Year: 2025, Volume and Issue: 272, P. 106976 - 106976

Published: Feb. 1, 2025

Plastics are everywhere. It is widely recognized that they represent a global problem, the extent of which yet to be defined. Humans broadly exposed plastics, whose effects and consequences poorly characterized so far. The main route exposure via alimentary respiratory intake. pollutions may come from both: water food contamination itself, their packaging. smaller sizes (i.e. microplastics <150 µm - MPs) considered most pervasive living organisms and, therefore, potentially harmful. As humans occupy one apex positions chain, we bioaccumulation biomagnification MPs. In fact, MPs commonly found in human stools blood. However, there no data available on ability accumulate produce detrimental biological systems. Even though plastics pollution studied mammals, including humans, appear have inflammatory effects, rather concerning as many etiologies disease based pro-inflammatory status.

Language: Английский

Citations

0