Herbal Therapies for Cancer Treatment: A Review of Phytotherapeutic Efficacy

Biologics, Journal Year: 2024, Volume and Issue: Volume 18, P. 229 - 255

Published: Sept. 1, 2024

Natural products have proven to be promising anti-cancer agents due their diverse chemical structures and bioactivity.This review examines central role in cancer treatment, focusing on mechanisms of action therapeutic benefits.Medicinal plants contain bioactive compounds, such as flavonoids, alkaloids, terpenoids polyphenols, which exhibit various anticancer properties.These compounds induce apoptosis, inhibit cell proliferation cycle progression, interfere with microtubule formation, act topoisomerase targets, angiogenesis, modulate key signaling pathways, improve the tumor microenvironment, reverse drug resistance activate immune cells.Herbal drugs offer advantages, particularly selective toxicity against cells, reducing adverse side effects associated conventional chemotherapy.Recent studies clinical trials highlight benefits herbal medicines alleviating effects, improving tolerance chemotherapy occurrence synergistic treatments.For example, medicine SH003 was found safe potentially effective treatment solid cancers, while Fucoidan showed anti-inflammatory properties that are beneficial for patients advanced cancer.The current research landscape is extensive.Numerous investigating efficacy, safety cancers lung, prostate, breast hepatocellular carcinoma.Promising developments include polypharmacological approach, combination therapies, immunomodulation improvement quality life.However, there still challenges development use natural drugs, need further into action, possible interactions optimal dosage.Standardizing extracts, bioavailability delivery, overcoming regulatory acceptance hurdles critical issues addressed.Nonetheless, warrant investigation development.Multidisciplinary collaboration essential advance therapy integrate these mainstream treatment.

Language: Английский

---

Current Advances in the Therapeutic Potential of Scutellarin: Novel Applications, Mechanisms, and Future Challenges.

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100754 - 100754

Published: Jan. 1, 2025

Language: Английский

---

2‐Undecanone induces ferroptosis via the STAT3/GPX4 pathway to enhance sensitivity of renal cell carcinoma to sunitinib

BioFactors, Journal Year: 2025, Volume and Issue: 51(2)

Published: March 1, 2025

Abstract The development of resistance significantly reduces the efficacy targeted therapies, such as sunitinib, in renal cell carcinoma (RCC) patients, emphasizing need for novel therapeutic agents. Natural products, known their diverse chemical structures and mechanisms action, offer promising anti‐tumor potential with favorable safety profiles lower toxicity compared to synthetic drugs. 2‐Undecanone, a natural compound extracted from Houttuynia cordata Thunb., has demonstrated effects, but its specific role RCC treatment remains unclear. In this study, we integrated network pharmacology vitro experiments explore underlying 2‐Undecanone's effects on RCC. Our results reveal that 2‐Undecanone effectively inhibits viability, proliferation, migration. Mechanistically, discovered induces ferroptosis cells by promoting reactive oxygen species (ROS) generation, intracellular Fe 2+ accumulation, glutathione (GSH) production, lipid peroxidation, modulation STAT3/GPX4 signaling pathway. Furthermore, lowers IC50 value sunitinib cells, enhancing sensitivity therapy. Additionally, potentiates sunitinib‐induced ferroptosis. summary, our research reveals enhances through targeting pathway, providing new insights into strategies

Language: Английский

---

Study on the Chemical Composition and Multidrug Resistance Reversal Activity of Euphorbia uralensis (Euphorbiaceae)

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 412 - 412

Published: Jan. 6, 2025

Euphorbia uralensis belongs to the family Euphorbiaceae and is widely distributed in northern Xinjiang, making it a characteristic plant of region China. The chemical composition biological activity have not yet been reported, although certain compounds isolated from plants China, demonstrated exceptional multidrug resistance (MDR) reversal. This study aims investigate components present with potential reverse MDR. aerial parts were extracted using organic solvents varying polarities, resulting dichloromethane (Fr-E) petroleum ether (Fr-S) fractions, which exhibited greater MDR reversal than other fractions. constituents Fr-S fraction analyzed GC-MS. Fr-E purified column chromatography. most effective screened out, mechanism was investigated molecular docking, dynamics simulations, Western blotting, rhodamine 123 staining. GC-MS analysis showed that rich triterpenes, fatty acids, phenols, long-chain alkanes, all identified for first time uralensis. Among these, palmitic acid at content level 15.86%. notably unveils discovery new compound 16 previously recorded this plant, main types as steroids, sesquiterpenes, flavonoids. tested cytotoxicity activity. Euphouralosides A, pubinernoid naringenin, punigratine good against MCF-7 MCF-7/ADR cell lines. Punigratine active compound. Moreover, could stably bind ABCB1 protein. blot revealed did affect expression protein cells (p > 0.05). However, following treatment (0.16 μM), there significant increase intracellular accumulation Rh123 < These findings suggest can inhibit efflux protein, thereby overcoming tumors. provides foundation further research on medicinal

Language: Английский

---

Exploring the therapeutic potential of natural products in modulating miRNA networks in prostate cancer

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Language: Английский

---

Polyphenols: Potential Applications in Cancer Therapy

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Polyphenols (PFs) are compounds found in fruits and vegetables, known for their health-related benefits, mainly including antioxidant, antiinflammatory, anticancer properties. However, efficacy is limited by poor bioavailability due to issues like low solubility, rapid metabolism, extensive excretion. Thus, research has focused on improving delivery systems, such as, example, nanoparticles, hydrogels, cocrystals, or conjugation with carrier molecules, which may protect PFs from degradation, improve and/or facilitate targeted cancer cells. promising modulating cancer-related pathways cell proliferation death, metastatic invasion, though translation patients hindered complex mechanisms. This review analyzes factors that affect PF bioavailability, evidences of vivo effects animal models mechanisms, results clinical trials, strategies enhance bioavailability. The idea need directly interact the challenged. Future aims optimize combine standard treatments, explore epigenetic effects, modulation tumor microenvironment, interactions gut microbiota. Advances personalized medicine structural modifications stability absorption could further potential. Despite challenges, remain a avenue complementary oncotherapy solutions.

Language: Английский

---

Warhead-bearing natural compounds for multi-pathway irreversible inhibition to overcome drug resistance in colorectal cancer

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(5)

Published: April 2, 2025

Language: Английский

---

The Role of Medicinal Plants in Modulating Epigenetic Mechanisms: Implications for Cancer Prevention and Therapy

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Cancer remains a significant global health challenge, with its progression driven by both genetic mutations and reversible epigenetic modifications. This review highlights the potential of phytochemicals to modulate mechanisms for cancer prevention treatment. Natural compounds such as quercetin, EGCG, genistein, β-elemene interact key processes DNA methylation, histone modifications, non-coding RNA regulation. These enable reactivation tumor suppressor genes, increased sensitivity conventional therapy mitigation drug resistance. For instance, EGCG improves efficacy cisplatin altering methylation patterns, while genistein influences breast through HER2 pathway However, challenges low bioavailability, variability in compound composition, need robust clinical validation remain. Further high-quality trials are required confirm safety these therapy.

Language: Английский

---

Targeting the MAPK signaling pathway: implications and prospects of flavonoids in 3P medicine as modulators of cancer cell plasticity and therapeutic resistance in breast cancer patients

The EPMA Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Abstract Cancer drug resistance poses a significant challenge in oncology, primarily driven by cancer cell plasticity, which promotes tumor initiation, progression, metastasis, and therapeutic evasion many different cancers. Breast cancers (BCs) are prominent example of that, with an estimated 2.3 million new cases 670,000 BC-related deaths registered worldwide annually. Triple-negative BC is especially challenging for treatments demonstrating particularly aggressive disease course, early manifestation metastatic disease, frequent drug-resistant types, poor individual outcomes. Although chemosensitizing agents have been developed, their clinical utility oncology remains unproven. The mitogen-activated protein kinase (MAPK) pathway considered critical regulator intracellular extracellular signaling highly relevant both — genetic epigenetic modifications. Dysregulation the MAPK pathways plays role conferring chemoresistance BC. Contextually, targeting represents promising strategy overcoming enhancing efficacy anticancer treatment. On other hand, flavonoids, class phytochemicals, key modulators signaling. Flavonoids interact ERK, JNK, p38, ERK5 cascade present avenue developing novel anti-cancer therapies re-sensitizing treatment Compounds such as quercetin, kaempferol, genistein, luteolin, myricetin, EGCG, baicalein, baicalin, nobiletin, morin, delphinidin, acacetin, isorhamnetin, apigenin, silymarin, among others, identified specific signaling, exerting complex downstream effects cells increasing therewith suppressing growth aggressivity. These properties reflect mechanisms great relevance to overcome overall management. This article highlights corresponding provides clinically illustrations framework 3P medicine primary (protection individuals at high risk against health-to-disease transition) secondary care progression). 3PM novelty makes good use patient phenotyping stratification, predictive multi-level diagnostics, application Artificial Intelligence (AI) tools individualized interpretation big data all proposed cost-effective tailored profiles clear benefits patients advanced

Language: Английский

---

Cancer chemoprevention: signaling pathways and strategic approaches

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: April 17, 2025

Abstract Although cancer chemopreventive agents have been confirmed to effectively protect high-risk populations from invasion or recurrence, only over ten drugs approved by the U.S. Food and Drug Administration. Therefore, screening potent is crucial reduce constantly increasing incidence mortality rate of cancer. Considering lengthy prevention process, an ideal agent should be nontoxic, inexpensive, oral. Natural compounds become a natural treasure reservoir for chemoprevention because their superior ease availability, cost-effectiveness, safety. The benefits as in various studies. In light this, present review intended fully delineate entire scope chemoprevention, primarily focuses on aspects based compounds, specifically focusing mechanism action prevention, discussing detail how they exert effects affecting classical signaling pathways, immune checkpoints, gut microbiome. We also introduce novel strategies summarize role improving chemotherapy regimens. Furthermore, we describe discovering anticancer with low abundance high activity, revealing broad prospects drug discovery chemoprevention. Moreover, associate precision medicine, discuss challenges encountered Finally, emphasize transformative potential advancing field ability more effective less toxic preventive options oncology.

Language: Английский

---