Environmental Temperature Variation Affects Brain Lipid Composition in Adult Zebrafish (Danio rerio) DOI Open Access
Elisa Maffioli, Simona Nonnis, Armando Negri

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9629 - 9629

Published: Sept. 5, 2024

This study delves deeper into the impact of environmental temperature variations on nervous system in teleost fish. Previous research has demonstrated that exposing adult zebrafish (Danio rerio) to 18 °C and 34 for 4 or 21 days induces behavioural changes compared fish kept at a control 26 °C, suggesting alterations system. Subsequent studies revealed these conditions also modify brain protein expression, indicating potential neurotoxic effects. The primary aim this work was investigate effects prolonged exposure (21 days) lipidomes temperature. Analysis lipidome highlighted significant alteration relative abundances specific lipid molecules confirming distinct induced by both tested temperatures. Exposure resulted an increase levels phospholipids, such as phosphatidylethanolamine, alongside general reduction sphingolipids, including sphingomyelin. Conversely, produced more pronounced effects, with increases phosphatidylethanolamine those various sphingolipids ceramide, gangliosides, sphingomyelin, ether lysophosphatidylethanolamine ether, phosphatidylglycerol well glycolipids like monogalactosyldiacylglycerol. These results, when integrated existing proteomic data, offer new insights thermal Specifically, our lipidomic findings suggest elevated temperatures may disrupt mitochondrial function, neuronal susceptibility oxidative stress cytotoxicity, alter axonal myelination, impair nerve impulse transmission, hinder synapse function neurotransmitter release, potentially lead increased death. are particularly relevant fields cell biology, neurobiology, ecotoxicology, especially context global warming.

Language: Английский

Type 2 Diabetes Mellitus: A Comprehensive Review of Pathophysiology, Comorbidities, and Emerging Therapies DOI
Aditi Singh,

Sucharita Shadangi,

Pulkit Kr. Gupta

et al.

Comprehensive physiology, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 1, 2025

ABSTRACT Humans are perhaps evolutionarily engineered to get deeply addicted sugar, as it not only provides energy but also helps in storing fats, which survival during starvation. Additionally, sugars (glucose and fructose) stimulate the feel‐good factor, they trigger secretion of serotonin dopamine brain, associated with reward sensation, uplifting mood general. However, when consumed excess, contributes imbalance, weight gain, obesity, leading onset a complex metabolic disorder, generally referred diabetes. Type 2 diabetes mellitus (T2DM) is one most prevalent forms diabetes, nearly affecting all age groups. T2DM clinically diagnosed cardinal sign chronic hyperglycemia (excessive sugar blood). Chronic hyperglycemia, coupled dysfunctions pancreatic β‐cells, insulin resistance, immune inflammation, further exacerbate pathology T2DM. Uncontrolled T2DM, major public health concern, significantly toward progression several micro‐ macrovascular diseases, such diabetic retinopathy, nephropathy, neuropathy, atherosclerosis, cardiovascular including cancer. The current review discusses epidemiology, causative factors, pathophysiology, comorbidities, existing emerging therapies related It future roadmap for alternative drug discovery management

Language: Английский

Citations

1
Emerging biomarkers in type 2 diabetes mellitus DOI
Rashid Mir, Mushabab Alghamdi,

Waad Fuad BinAfif

et al.

Advances in clinical chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Ceramide: a central regulator in Alzheimer’s disease pathogenesis DOI
Priyanka Choudhary,

Shilpa Kumari,

Kajal Bagri

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Language: Английский

Citations

0
From Lipids to Glucose: Investigating the Role of Dyslipidemia in the Risk of Insulin Resistance DOI

Mahtab Jahdkaran,

Mohammad Sistanizad

The Journal of Steroid Biochemistry and Molecular Biology, Journal Year: 2025, Volume and Issue: unknown, P. 106744 - 106744

Published: March 1, 2025

Language: Английский

Citations

0
Environmental Temperature Variation Affects Brain Lipid Composition in Adult Zebrafish (Danio rerio) DOI Open Access
Elisa Maffioli, Simona Nonnis, Armando Negri

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9629 - 9629

Published: Sept. 5, 2024

This study delves deeper into the impact of environmental temperature variations on nervous system in teleost fish. Previous research has demonstrated that exposing adult zebrafish (Danio rerio) to 18 °C and 34 for 4 or 21 days induces behavioural changes compared fish kept at a control 26 °C, suggesting alterations system. Subsequent studies revealed these conditions also modify brain protein expression, indicating potential neurotoxic effects. The primary aim this work was investigate effects prolonged exposure (21 days) lipidomes temperature. Analysis lipidome highlighted significant alteration relative abundances specific lipid molecules confirming distinct induced by both tested temperatures. Exposure resulted an increase levels phospholipids, such as phosphatidylethanolamine, alongside general reduction sphingolipids, including sphingomyelin. Conversely, produced more pronounced effects, with increases phosphatidylethanolamine those various sphingolipids ceramide, gangliosides, sphingomyelin, ether lysophosphatidylethanolamine ether, phosphatidylglycerol well glycolipids like monogalactosyldiacylglycerol. These results, when integrated existing proteomic data, offer new insights thermal Specifically, our lipidomic findings suggest elevated temperatures may disrupt mitochondrial function, neuronal susceptibility oxidative stress cytotoxicity, alter axonal myelination, impair nerve impulse transmission, hinder synapse function neurotransmitter release, potentially lead increased death. are particularly relevant fields cell biology, neurobiology, ecotoxicology, especially context global warming.

Language: Английский

Citations

2