Hemoglobin, albumin, lymphocyte, and platelet (HALP) score: A risk prediction tool for incidence and mortality in diabetic kidney disease patients with type 2 diabetes DOI Creative Commons

Lingzhi Xing,

Fang Xie, Zhaoyang Zhong

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Abstract Background The hemoglobin, albumin, lymphocyte, and platelet (HALP) score has been identified as a potential prognostic marker in various conditions. However, its relationship with the incidence mortality of diabetic kidney disease (DKD) type 2 diabetes patients remains unexplored. This study aims to explore between HALP both DKD diabetes, well whether reversing could reduce outcomes. Methods included 25,750 from National Health Nutrition Examination Survey (NHANES) (1999–2018) Southwest China (2013–2022). was calculated [hemoglobin (g/L) × albumin (g/L)×lymphocytes (/L)]/platelets (/L). diagnosed based on urine creatinine ratio (ACR) ≥ 30 mg/g and/or estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m². explored using logistic regression model, Cox models were used evaluate association all-cause cause-specific mortality. Subgroup analyses effects dietary fiber intake NSAIDs use Results Higher significantly associated lower risk (NHANES, HR 0.502; China, 0.528) an antagonist manner. Additionally, higher related decreased (HR 0.765, p 0.001) cardiovascular disease(CVD)-related mortality(HR 0.667, 0.001).We also discovered same outcome low 0.695, or 0.733, 0.001). magnitude associations not materially altered any sensitivity analyses. Conclusions High independently Regular monitoring aid stratification clinical decisions for diabetes.

Language: Английский

Histone methylation modification and diabetic kidney disease: Potential molecular mechanisms and therapeutic approaches (Review) DOI
Peng Qu, Lanfang Li, Qi Jin

et al.

International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 54(5)

Published: Sept. 17, 2024

Diabetic kidney disease (DKD) is the leading cause of chronic and end‑stage renal disease, characterized by persistent proteinuria decreased glomerular filtration rate. Despite extensive efforts, increasing incidence highlights urgent need for more effective treatments. Histone methylation a crucial epigenetic modification, its alteration can destabilize chromatin structure, thereby regulating transcriptional activity specific genes. serves substantial role in onset progression various diseases. In patients with DKD, changes histone are pivotal mediating interactions between genetic environmental factors. Targeting these modifications shows promise ameliorating histological manifestations, tissue fibrosis proteinuria, represents novel therapeutic frontier potential to halt DKD progression. The present review focuses on alterations during development systematically summarizes impact parenchymal cells underscores targeted improving outcomes.

Language: Английский

Citations

1
Hemoglobin, albumin, lymphocyte, and platelet (HALP) score: A risk prediction tool for incidence and mortality in diabetic kidney disease patients with type 2 diabetes DOI Creative Commons

Lingzhi Xing,

Fang Xie, Zhaoyang Zhong

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Abstract Background The hemoglobin, albumin, lymphocyte, and platelet (HALP) score has been identified as a potential prognostic marker in various conditions. However, its relationship with the incidence mortality of diabetic kidney disease (DKD) type 2 diabetes patients remains unexplored. This study aims to explore between HALP both DKD diabetes, well whether reversing could reduce outcomes. Methods included 25,750 from National Health Nutrition Examination Survey (NHANES) (1999–2018) Southwest China (2013–2022). was calculated [hemoglobin (g/L) × albumin (g/L)×lymphocytes (/L)]/platelets (/L). diagnosed based on urine creatinine ratio (ACR) ≥ 30 mg/g and/or estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m². explored using logistic regression model, Cox models were used evaluate association all-cause cause-specific mortality. Subgroup analyses effects dietary fiber intake NSAIDs use Results Higher significantly associated lower risk (NHANES, HR 0.502; China, 0.528) an antagonist manner. Additionally, higher related decreased (HR 0.765, p 0.001) cardiovascular disease(CVD)-related mortality(HR 0.667, 0.001).We also discovered same outcome low 0.695, or 0.733, 0.001). magnitude associations not materially altered any sensitivity analyses. Conclusions High independently Regular monitoring aid stratification clinical decisions for diabetes.

Language: Английский

Citations

0