Neural circuit mechanisms of epilepsy: Maintenance of homeostasis at the cellular, synaptic, and neurotransmitter levels DOI Creative Commons

Xueqing Du,

Yi Wang, Xuefeng Wang

et al.

Neural Regeneration Research, Journal Year: 2025, Volume and Issue: 21(2), P. 455 - 465

Published: Jan. 13, 2025

Epilepsy, a common neurological disorder, is characterized by recurrent seizures that can lead to cognitive, psychological, and neurobiological consequences. The pathogenesis of epilepsy involves neuronal dysfunction at the molecular, cellular, neural circuit levels. Abnormal molecular signaling pathways or specific cell types disrupting normal functioning circuits. continuous emergence new technologies rapid advancement existing ones have facilitated discovery comprehensive understanding mechanisms underlying epilepsy. Therefore, this review aims investigate current in based on various technologies, including electroencephalography, magnetic resonance imaging, optogenetics, chemogenetics, deep brain stimulation, brain–computer interfaces. Additionally, discusses these from three perspectives: structural, synaptic, transmitter findings reveal encompass information transmission among different structures, interactions within same structure, maintenance homeostasis neurotransmitter These offer insights for investigating pathophysiological enhancing its clinical diagnosis treatment.

Language: Английский

Dopaminergic modulation of propofol-induced activation in VLPO neurons: the role of D1 receptors in sleep-promoting neural circuits DOI Creative Commons
Kun Qian, Yu Zhang, Yang Liu

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 8, 2025

The ventrolateral preoptic nucleus (VLPO) is a crucial regulator of sleep, and its neurons are implicated in both sleep-wake regulation anesthesia-induced loss consciousness. Propofol (PRO), widely used intravenous anesthetic, modulates the activity VLPO neurons, but underlying mechanisms, particularly role dopaminergic receptors, remain unclear. This study aimed to investigate effects PRO on NA (-) determine involvement D1 D2 receptors mediating these effects. Using vitro patch-clamp techniques, we identified characterized (+) based their morphological, pharmacological, electrophysiological properties. We assessed spontaneous excitatory postsynaptic currents (sEPSCs) inhibitory (sIPSCs) presence absence receptor modulators. significantly increased firing frequency while decreasing neurons. activation was mediated through GABA_A as evidenced by sEPSCs altered sIPSCs dynamics. Dopamine (DA) attenuated PRO-induced increase suppression via not receptors. Blocking with SCH23390 reversed DA changes, antagonist sulpiride had minimal impact. Our findings demonstrate that excites sleep-promoting VLPO, primarily modulation occurring These results provide new insights into neural mechanisms general anesthesia highlight potential signaling modulating anesthetic sleep-related circuits.

Language: Английский

Citations

0
Relationships and representations of brain structures, connectivity, dynamics and functions DOI
Oliver Schmitt

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111332 - 111332

Published: March 1, 2025

Language: Английский

Citations

0
Neural circuit mechanisms of epilepsy: Maintenance of homeostasis at the cellular, synaptic, and neurotransmitter levels DOI Creative Commons

Xueqing Du,

Yi Wang, Xuefeng Wang

et al.

Neural Regeneration Research, Journal Year: 2025, Volume and Issue: 21(2), P. 455 - 465

Published: Jan. 13, 2025

Epilepsy, a common neurological disorder, is characterized by recurrent seizures that can lead to cognitive, psychological, and neurobiological consequences. The pathogenesis of epilepsy involves neuronal dysfunction at the molecular, cellular, neural circuit levels. Abnormal molecular signaling pathways or specific cell types disrupting normal functioning circuits. continuous emergence new technologies rapid advancement existing ones have facilitated discovery comprehensive understanding mechanisms underlying epilepsy. Therefore, this review aims investigate current in based on various technologies, including electroencephalography, magnetic resonance imaging, optogenetics, chemogenetics, deep brain stimulation, brain–computer interfaces. Additionally, discusses these from three perspectives: structural, synaptic, transmitter findings reveal encompass information transmission among different structures, interactions within same structure, maintenance homeostasis neurotransmitter These offer insights for investigating pathophysiological enhancing its clinical diagnosis treatment.

Language: Английский

Citations

0