Structural characteristics, functions, and counteracting strategies of biofilms in Staphylococcus aureus

Computational and Structural Biotechnology Journal, Journal Year: 2025, Volume and Issue: 27, P. 488 - 500

Published: Jan. 1, 2025

Staphylococcus aureus (S. aureus) is a prevalent pathogen associated with wide range of infections, exhibiting significant antibiotic resistance and posing therapeutic challenges in clinical settings. The formation biofilms contributes to the emergence resistant strains, further diminishing efficacy antibiotics. This, turn, leads chronic recurrent ultimately increasing healthcare burden. Consequently, preventing eliminating has become critical focus management research. This review systematically examines mechanisms underlying biofilm S. its contribution resistance, emphasizing essential roles play maintaining structural integrity enhancing resistance. It also analyses protective that fortify against antimicrobial treatments. Furthermore, provides comprehensive overview recent innovations, including enzymatic therapy, nanotechnology, gene editing, phage therapy. Emerging strategies present novel approaches combat biofilm-associated infections through various mechanisms. discusses advancements these therapies, their practical application, an in-depth analysis each strategy's potential. By mapping future research directions, this aims refine anti-biofilm control infection progression effectively mitigate recurrence.

Language: Английский

Disarming Staphylococcus aureus: Review of Strategies Combating This Resilient Pathogen by Targeting Its Virulence

Pathogens, Journal Year: 2025, Volume and Issue: 14(4), P. 386 - 386

Published: April 15, 2025

Staphylococcus aureus is a formidable pathogen notorious for its antibiotic resistance and diverse virulence mechanisms, including toxin production, biofilm formation, immune evasion. This article explores innovative anti-virulence strategies to disarm S. by targeting critical factors without exerting bactericidal pressure. Key approaches include inhibiting adhesion neutralizing toxins, disrupting quorum sensing (e.g., Agr system inhibitors), blocking iron acquisition pathways. Additionally, interventions two-component regulatory systems are highlighted. While promising, challenges such as strain variability, resilience, pharmacokinetic limitations, evolution underscore the need combination therapies advanced formulations. Integrating with traditional antibiotics host-directed offers sustainable solution combat multidrug-resistant aureus, particularly methicillin-resistant strains (MRSA), mitigate global public health crisis.

Language: Английский