Fungal Biomolecules for Food and Pharmaceutical Application

eFood, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 20, 2025

ABSTRACT Mushrooms have long been an integral part of human culture and health are valued for their nutritional therapeutic properties. Often referred to as a superfood, mushrooms rich in bioactive compounds that provide range benefits including antioxidant, antimicrobial, anticancer, prebiotic, antidiabetic, anti‐inflammatory effects. This review focussed on the diversity mushrooms, emphasizing medicinal significance, explores secondary metabolites with potential applications nutraceuticals pharmaceuticals. It underscores role vital agents developing value‐added products. An overview compounds, such polysaccharides, peptides, proteins, terpenoids, phenolic identified numerous mushroom species. Additionally, addresses advancements fungal biotechnology, particularly use fungi efficient industrial cell factories, influence food quality sustainability. By critically analyzing recent studies, summarizes diverse roles biomolecules pharmaceutical industries highlights significant contribution modern medicine health‐related fields.

Language: Английский

Antrodia cinnamomea Formula Suppresses Prostate Cancer Progression via Immune Modulation and PD-1/PD-L1 Pathway Inhibition

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2684 - 2684

Published: March 17, 2025

Prostate cancer remains a significant global health challenge, necessitating the development of novel therapeutic approaches. This study investigated potential Antrodia cinnamomea formula (XIANZHIFANG formula, XZF), comprising cinnamomea, Sanghuangporus sanghuang, Ganoderma lucidum, sinense, and Inonotus obliquus, in prostate treatment. HPLC analysis confirmed presence key triterpenoids, including Antcin A, B, C, K, Zhankuic acid 4,7-dimethoxy-5-methyl-1,3-benzodioxole. Cytotoxicity assays demonstrated that XZF (50–200 μg/mL) exhibited selective activity, maintaining viability non-cancerous 293T-cells while enhancing activated CD8+ CD4+ T-cells dose-dependent manner. significantly reduced PD-1 expression but not inhibited PD-L1/PD-1 interaction, achieving 93% inhibition at 200 μg/mL. Furthermore, when combined with atezolizumab (1 μg/mL), complete blockade interaction. In cells, differential antiproliferative effects. PC-3 across concentration range 25–200 μg/mL, whereas DU145 cells showed only partial higher concentrations (100–200 μg/mL). LNCaP reduction viability, mirroring response pattern cells. Conditioned medium from XZF-treated macrophages, particularly human THP-1 suppressed migration Notably, conditioned stronger inhibitory effect on cell compared to murine RAW 264.7 macrophages. These findings indicate exerts its through multiple mechanisms, direct effects enhancement T-cell responses, modulation immune checkpoint pathways, macrophage-mediated suppression survival migration. The pronounced observed macrophage models suggest promising avenue for further investigation clinical settings, combination existing immunotherapies.

Language: Английский

Protective effect of Antroquinonol B, an active ingredient of Antrodia camphorata, on acute liver injury

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 128, P. 106836 - 106836

Published: April 22, 2025

Language: Английский