Biomedical Reports,
Journal Year:
2024,
Volume and Issue:
22(3)
Published: Dec. 27, 2024
Obesity
is
a
pervasive
global
health
challenge
that
substantially
reduces
the
quality
of
life
millions
individuals
and
impedes
social
economic
advancement.
an
independent
risk
factor
contributes
to
range
chronic
non‑communicable
metabolic
diseases,
significantly
affecting
energy
metabolism,
mental
health,
cancer
susceptibility,
sleep
quality,
other
physiological
processes.
The
PI3K/AKT
signaling
pathway,
significant
glucose,
lipid,
protein
metabolism
regulator,
integral
cellular
growth,
survival,
apoptosis.
Apoptosis
highly
regulated
form
programmed
cell
death
critical
for
immune
maturation
tissue
repair.
present
review
examines
association
between
obesity,
mitochondrial
apoptosis
elucidate
potential
mechanisms
by
which
obesity
may
activate
apoptotic
pathways.
These
findings
provide
theoretical
foundation
mitigating
obesity‑related
complications
targeting
these
Critical Reviews in Biotechnology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 19
Published: Jan. 6, 2025
This
comprehensive
review
aims
to
explore
and
consolidate
the
current
knowledge
on
dendrobine,
including
its
biological
activities,
molecular
mechanisms
of
action,
effects
various
physiological
processes,
potential
toxicity,
safety
considerations,
in
order
unlock
full
applications.
Dendrobine
has
diverse
effects,
anti-inflammatory,
antioxidant,
neuroprotective,
immunomodulatory,
anticancer
effects.
also
exerts
neuroprotective
by
boosting
neuronal
survival,
reducing
neuroinflammation,
regulating
neurotransmitter
release.
immunomodulatory
that
control
immune
cell
function
modify
immunological
responses.
exhibits
properties
decreasing
tumor
angiogenesis
metastasis,
causing
apoptosis
cancer
cells,
inhibiting
growth.
discusses
idea
a
circular
economy
produce
researching
cutting-edge
sustainable
methods
maximize
resource
efficiency
reduce
environmental
Additionally,
supporting
principles
for
production
outlining
future
study
areas,
this
discovery
will
help
use
dendrobine
variety
applications
while
preserving
environment.
Future
research
should
focus
advancing
application
personalized
medicine,
exploring
green
bioproduction
methods,
ensuring
ethical
sourcing
practices.
An
enhanced
understanding
synergistic
therapies
could
revolutionize
healthcare,
whereas
conservation
efforts
safeguard
ecological
impact.
Gut Microbes,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Jan. 2, 2025
Diabetes
mellitus
(DM)
is
a
complex
metabolic
disease
characterized
by
hyperglycemia.
Recently,
the
incidence
of
diabetes
has
increased
exponentially,
and
it
estimated
to
become
seventh
leading
cause
global
mortality
2030.
Glucagon-like
peptide-1
(GLP-1),
hormone
derived
from
intestine,
been
demonstrated
exert
remarkable
hypoglycemic
effects.
However,
its
limitation
lies
in
short
plasma
half-life,
necessitating
continuous
intravenous
injection
GLP-1
drugs
achieve
efficacy.
Here,
we
engineered
Clostridium
butyricum
continuously
express
deliver
(denoted
as
Cb-GLP-1),
assessed
therapeutic
efficacy
type
2
(T2DM)
mice.
We
that
administration
Cb-GLP-1
effectively
lowered
blood
glucose
levels,
regulated
dyslipidemia,
ameliorated
hepatic
impairment
T2DM
Furthermore,
treatment
facilitated
insulin
secretion
retarding
islet
cell
apoptosis
activating
glucagon-like
peptide
1
receptor/adenylate
cyclase/protein
kinase
A
(GLP-1
R/AC/PKA)
signaling
pathway.
Gut
microbiota
analysis
revealed
restored
gut
homeostasis
disrupted
mice,
indicated
decreased
abundance
Lactobacillus
Providencia
genera
response
treatment.
Collectively,
intestinal
regulation
effect
strain
presents
promising
approach
for
management.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 23, 2025
Abstract
Niclosamide,
initially
developed
as
an
anthelmintic,
has
recently
emerged
a
potential
antiviral,
showing
efficacy
against
diverse
viral
threats,
including
Mpox.
As
the
global
health
landscape
faces
recurrent
Mpox
outbreaks,
repurposing
niclosamide
through
advanced
material
strategies
offers
promising
therapeutic
avenues.
This
article
explores
antiviral
mechanisms
of
niclosamide,
focusing
on
how
innovative
nano‐hybrid
formulations
enhance
its
bioavailability
and
pharmacological
performance.
By
leveraging
nanohybridization,
niclosamide's
limitations—such
poor
solubility
bioavailability—are
addressed,
enabling
targeted
delivery
sustained
release.
Early
preclinical
studies
reveal
that
disrupts
replication
entry
processes,
suggesting
utility
option
poxvirus
infections.
Looking
forward,
further
in
vitro,
animal
models,
clinical
investigations
are
essential
to
optimize
application
dosing
for
With
continued
development
materials,
nanohybrid
could
become
critical
tool
managing
related
offering
accessible,
cost‐effective
outbreak
preparedness.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 18, 2025
Trigonella
foenum-graecum
L.
(HLB)
exhibits
promising
pharmacological
properties
for
the
treatment
of
type
2
diabetic
nephropathy
(DN).
This
study
aims
to
enhance
understanding
HLB's
pharmacodynamic
effects
and
elucidate
mechanisms
underlying
its
therapeutic
potential
in
DN.
The
HLB
were
initially
evaluated
a
murine
DN
model
through
oral
administration
an
aqueous
extract
HLB.
primary
bioactive
constituents
subsequently
identified
using
ultra-high-performance
liquid
chromatography
coupled
with
high-resolution
mass
spectrometry
(UHPLC-HRMS).
Network
pharmacology
analysis
was
integrated
these
data
uncover
molecular
targets
Key
renal
metabolites
profiled
untargeted
metabolomics,
followed
by
metabolic
pathway
enrichment
conducted
MetaboAnalyst
6.0
platform,
which
facilitated
identification
relevant
pathways
modulates
Finally,
quantitative
real-time
polymerase
chain
reaction
(QRT-PCR)
Western
blot
(WB)
techniques
employed
validate
expression
levels
key
genes
proteins,
thereby
confirming
Animal
experiments
indicated
that
significantly
improved
blood
glucose
regulation
function
while
reducing
oxidative
stress
abnormalities
lipid
metabolism
mice.
A
total
34
compounds
159
as
active
components
metabolomics
revealed
61
critical
metabolites,
among
PI3K-Akt-ERK
signaling
pathway-known
be
involved
diabetes-was
highlighted
crucial
pathway.
QRT-PCR
WB
analyses
demonstrated
upregulated
MAPK1,
MAPK3,
AKT1,
PI3K.
These
results
suggest
may
alleviate
modulating
metabolism.
Its
are
likely
mediated
pathway,
along
upregulation
PI3K
expression.
lays
groundwork
further
investigations
into
action
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(18), P. 10066 - 10066
Published: Sept. 19, 2024
This
study
investigated
the
therapeutic
potential
of
licochalcone
D
(LicoD),
which
is
derived
from
Glycyrrhiza
uralensis,
for
improving
glucose
metabolism
in
AML12
hepatocytes
with
high-glucose-induced
insulin
resistance
(IR).
Ultra-high-performance
liquid
chromatography–mass
spectrometry
revealed
that
LicoD
content
G.
uralensis
was
8.61
µg/100
mg
ethanol
extract
(GUE)
and
0.85
hot
water
extract.
GUE
enhanced
consumption
uptake,
as
well
Glut2
mRNA
expression,
IR
cells.
These
effects
were
associated
activation
receptor
substrate/phosphatidylinositol-3
kinase
signaling
pathway,
increased
protein
B
α
phosphorylation,
suppression
gluconeogenesis-related
genes,
such
Pepck
G6pase.
Furthermore,
promoted
glycogen
synthesis
by
downregulating
phosphorylase.
mitigated
downregulated
expression
mitochondrial
oxidative
phosphorylation
proteins
activating
PPARα/PGC1α
pathway
increasing
DNA
content.
findings
demonstrate
options
alleviating
IR-induced
metabolic
disorders
function.
