Role of Peroxisome Proliferator-Activated Receptor α-Dependent Mitochondrial Metabolism in Ovarian Cancer Stem Cells DOI Open Access
Seo Yul Lee,

Min Joo Shin,

Seong Min Choi

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11760 - 11760

Published: Nov. 1, 2024

Peroxisome proliferator-activated receptors (PPARs), including PPAR-α, PPAR-β/δ, and PPAR-γ, are involved in various cellular responses, metabolism cell proliferation. Increasing evidence suggests that PPARs closely associated with tumorigenesis metastasis. However, the exact role of energy cancer stem (CSC) proliferation remains unclear. This study investigated ovarian CSCs. The expression fatty acid consumption as an source increased spheroids derived from A2780 cells (A2780-SP) compared their parental cells. GW6471, a PPARα inhibitor, induced apoptosis A2780-SP. silencing mediated by small hairpin RNA reduced A2780-SP Treatment GW6471 significantly inhibited respiratory oxygen cells, dependency on acids, glucose, glutamine. In xenograft tumor transplantation mouse model, intraperitoneal injection vivo growth These results suggest plays vital regulating CSCs altering mitochondrial activity it offers promising therapeutic target to eradicate

Language: Английский

Role of Peroxisome Proliferator-Activated Receptor α-Dependent Mitochondrial Metabolism in Ovarian Cancer Stem Cells DOI Open Access
Seo Yul Lee,

Min Joo Shin,

Seong Min Choi

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11760 - 11760

Published: Nov. 1, 2024

Peroxisome proliferator-activated receptors (PPARs), including PPAR-α, PPAR-β/δ, and PPAR-γ, are involved in various cellular responses, metabolism cell proliferation. Increasing evidence suggests that PPARs closely associated with tumorigenesis metastasis. However, the exact role of energy cancer stem (CSC) proliferation remains unclear. This study investigated ovarian CSCs. The expression fatty acid consumption as an source increased spheroids derived from A2780 cells (A2780-SP) compared their parental cells. GW6471, a PPARα inhibitor, induced apoptosis A2780-SP. silencing mediated by small hairpin RNA reduced A2780-SP Treatment GW6471 significantly inhibited respiratory oxygen cells, dependency on acids, glucose, glutamine. In xenograft tumor transplantation mouse model, intraperitoneal injection vivo growth These results suggest plays vital regulating CSCs altering mitochondrial activity it offers promising therapeutic target to eradicate

Language: Английский

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